PDB entry 6hyc

View 6hyc on RCSB PDB site
Description: the structure of full-length human phenylalanine hydroxylase in complex with the cofactor and negative regulator tetrahydrobiopterin
Deposited on 2018-10-19, released 2019-06-05
The last revision was dated 2019-06-19, with a file datestamp of 2019-06-14.
Experiment type: XRAY
Resolution: 3.18 Å
R-factor: N/A
AEROSPACI score: 0.11 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: phenylalanine-4-hydroxylase
    Species: Homo sapiens [TaxId:9606]
    Gene: PAH
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: phenylalanine-4-hydroxylase
    Species: Homo sapiens [TaxId:9606]
    Gene: PAH
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: phenylalanine-4-hydroxylase
    Species: Homo sapiens [TaxId:9606]
    Gene: PAH
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: phenylalanine-4-hydroxylase
    Species: Homo sapiens [TaxId:9606]
    Gene: PAH
    Database cross-references and differences (RAF-indexed):
  • Heterogens: H4B, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6hycA (A:)
mstavlenpglgrklsdfgqetsyiedncnqngaislifslkeevgalakvlrlfeendv
nlthiesrpsrlkkdeyeffthldkrslpaltniikilrhdigatvhelsrdkkkdtvpw
fprtiqeldrfanqilsygaeldadhpgfkdpvyrarrkqfadiaynyrhgqpiprveym
eeekktwgtvfktlkslykthacyeynhifpllekycgfhednipqledvsqflqtctgf
rlrpvagllssrdflgglafrvfhctqyirhgskpmytpepdichellghvplfsdrsfa
qfsqeiglaslgapdeyieklatiywftvefglckqgdsikaygagllssfgelqyclse
kpkllplelektaiqnytvtefqplyyvaesfndakekvrnfaatiprpfsvrydpytqr
ievldntqqlkiladsinseigilcsalqkik

    Sequence, based on observed residues (ATOM records):
    >6hycA (A:)
tsyiedncnqngaislifslkeevgalakvlrlfeendvnlthiesrpsrlkkdeyefft
hldkrslpaltniikilrhdigatvhelsrdkkkdtvpwfprtiqeldrfanqildadhp
gfkdpvyrarrkqfadiaynyrhgqpiprveymeeekktwgtvfktlkslykthacyeyn
hifpllekycgfhednipqledvsqflqtctgfrlrpvagllssrdflgglafrvfhctq
yirhgskpmytpepdichellghvplfsdrsfaqfsqeiglaslgapdeyieklatiywf
tvefglckqgdsikaygagllssfgelqyclsekpkllplelektaiqnytvtefqplyy
vaesfndakekvrnfaatiprpfsvrydpytqrievldntqqlkiladsinseigilcsa
lqk

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6hycB (B:)
mstavlenpglgrklsdfgqetsyiedncnqngaislifslkeevgalakvlrlfeendv
nlthiesrpsrlkkdeyeffthldkrslpaltniikilrhdigatvhelsrdkkkdtvpw
fprtiqeldrfanqilsygaeldadhpgfkdpvyrarrkqfadiaynyrhgqpiprveym
eeekktwgtvfktlkslykthacyeynhifpllekycgfhednipqledvsqflqtctgf
rlrpvagllssrdflgglafrvfhctqyirhgskpmytpepdichellghvplfsdrsfa
qfsqeiglaslgapdeyieklatiywftvefglckqgdsikaygagllssfgelqyclse
kpkllplelektaiqnytvtefqplyyvaesfndakekvrnfaatiprpfsvrydpytqr
ievldntqqlkiladsinseigilcsalqkik

    Sequence, based on observed residues (ATOM records):
    >6hycB (B:)
etsyiedncnqngaislifslkeevgalakvlrlfeendvnlthiesrpsrlkkdeyeff
thldkrslpaltniikilrhdigatvhelsrdkkkdtvpwfprtiqeldrfanqildadh
pgfkdpvyrarrkqfadiaynyrhgqpiprveymeeekktwgtvfktlkslykthacyey
nhifpllekycgfhednipqledvsqflqtctgfrlrpvagllssrdflgglafrvfhct
qyirhgskpmytpepdichellghvplfsdrsfaqfsqeiglaslgapdeyieklatiyw
ftvefglckqgdsikaygagllssfgelqyclsekpkllplelektaiqnytvtefqply
yvaesfndakekvrnfaatiprpfsvrydpytqrievldntqqlkiladsinseigilcs
alqk

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6hycC (C:)
mstavlenpglgrklsdfgqetsyiedncnqngaislifslkeevgalakvlrlfeendv
nlthiesrpsrlkkdeyeffthldkrslpaltniikilrhdigatvhelsrdkkkdtvpw
fprtiqeldrfanqilsygaeldadhpgfkdpvyrarrkqfadiaynyrhgqpiprveym
eeekktwgtvfktlkslykthacyeynhifpllekycgfhednipqledvsqflqtctgf
rlrpvagllssrdflgglafrvfhctqyirhgskpmytpepdichellghvplfsdrsfa
qfsqeiglaslgapdeyieklatiywftvefglckqgdsikaygagllssfgelqyclse
kpkllplelektaiqnytvtefqplyyvaesfndakekvrnfaatiprpfsvrydpytqr
ievldntqqlkiladsinseigilcsalqkik

    Sequence, based on observed residues (ATOM records):
    >6hycC (C:)
tsyiedncnqngaislifslkeevgalakvlrlfeendvnlthiesrpsrlkkdeyefft
hldkrslpaltniikilrhdigatvhelsrdkkkdtvpwfprtiqeldrfanqildadhp
gfkdpvyrarrkqfadiaynyrhgqpiprveymeeekktwgtvfktlkslykthacyeyn
hifpllekycgfhednipqledvsqflqtctgfrlrpvagllssrdflgglafrvfhctq
yirhgskpmytpepdichellghvplfsdrsfaqfsqeiglaslgapdeyieklatiywf
tvefglckqgdsikaygagllssfgelqyclsekpkllplelektaiqnytvtefqplyy
vaesfndakekvrnfaatiprpfsvrydpytqrievldntqqlkiladsinseigilcsa
lqk

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6hycD (D:)
mstavlenpglgrklsdfgqetsyiedncnqngaislifslkeevgalakvlrlfeendv
nlthiesrpsrlkkdeyeffthldkrslpaltniikilrhdigatvhelsrdkkkdtvpw
fprtiqeldrfanqilsygaeldadhpgfkdpvyrarrkqfadiaynyrhgqpiprveym
eeekktwgtvfktlkslykthacyeynhifpllekycgfhednipqledvsqflqtctgf
rlrpvagllssrdflgglafrvfhctqyirhgskpmytpepdichellghvplfsdrsfa
qfsqeiglaslgapdeyieklatiywftvefglckqgdsikaygagllssfgelqyclse
kpkllplelektaiqnytvtefqplyyvaesfndakekvrnfaatiprpfsvrydpytqr
ievldntqqlkiladsinseigilcsalqkik

    Sequence, based on observed residues (ATOM records):
    >6hycD (D:)
tsyiedncnqngaislifslkeevgalakvlrlfeendvnlthiesrpsrlkkdeyefft
hldkrslpaltniikilrhdigatvhelsrdkkkdtvpwfprtiqeldrfanqildadhp
gfkdpvyrarrkqfadiaynyrhgqpiprveymeeekktwgtvfktlkslykthacyeyn
hifpllekycgfhednipqledvsqflqtctgfrlrpvagllssrdflgglafrvfhctq
yirhgskpmytpepdichellghvplfsdrsfaqfsqeiglaslgapdeyieklatiywf
tvefglckqgdsikaygagllssfgelqyclsekpkllplelektaiqnytvtefqplyy
vaesfndakekvrnfaatiprpfsvrydpytqrievldntqqlkiladsinseigilcsa
lqk