PDB entry 6hxw

View 6hxw on RCSB PDB site
Description: structure of human cd73 in complex with antibody iph53
Deposited on 2018-10-18, released 2019-08-28
The last revision was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 2.78 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 5'-nucleotidase
    Species: Homo sapiens [TaxId:9606]
    Gene: NT5E, NT5, NTE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21589 (0-End)
      • conflict (521-522)
  • Chain 'B':
    Compound: 5'-nucleotidase
    Species: Homo sapiens [TaxId:9606]
    Gene: NT5E, NT5, NTE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21589 (0-End)
      • conflict (521-522)
  • Chain 'C':
    Compound: IPH53 heavy chain
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6HXW (0-End)
  • Chain 'D':
    Compound: IPH53 light chain
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6HXW (0-208)
  • Chain 'H':
    Compound: IPH53 heavy chain
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6HXW (0-End)
  • Chain 'L':
    Compound: IPH53 light chain
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6HXW (0-208)
  • Heterogens: NAG, ZN, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6hxwA (A:)
weltilhtndvhsrleqtsedsskcvnasrcmggvarlftkvqqirraepnvllldagdq
yqgtiwftvykgaevahfmnalrydamalgnhefdngvegliepllkeakfpilsanika
kgplasqisglylpykvlpvgdevvgivgytsketpflsnpgtnlvfedeitalqpevdk
lktlnvnkiialghsgfemdkliaqkvrgvdvvvgghsntflytgnppskevpagkypfi
vtsddgrkvpvvqayafgkylgylkiefdergnvisshgnpillnssipedpsikadink
wrikldnystqelgktivyldgssqscrfrecnmgnlicdaminnnlrhtdemfwnhvsm
cilngggirspidernngtitwenlaavlpfggtfdlvqlkgstlkkafehsvhrygqst
geflqvggihvvydlsrkpgdrvvkldvlctkcrvpsydplkmdevykvilpnflanggd
gfqmikdellrhdsgdqdinvvstyiskmkviypavegrikhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6hxwA (A:)
weltilhtndvhsrleqtsedsskcvnasrcmggvarlftkvqqirraepnvllldagdq
yqgtiwftvykgaevahfmnalrydamalgnhefdngvegliepllkeakfpilsanika
kgplasqisglylpykvlpvgdevvgivgytsketpflsnpgtnlvfedeitalqpevdk
lktlnvnkiialghsgfemdkliaqkvrgvdvvvgghsntflytgnppskevpagkypfi
vtsddgrkvpvvqayafgkylgylkiefdergnvisshgnpillnssipedpsikadink
wrikldnystqelgktivyldgssqscrfrecnmgnlicdaminnnlrhtdemfwnhvsm
cilngggirspidernngtitwenlaavlpfggtfdlvqlkgstlkkafehsvhrygqst
geflqvggihvvydlsrkpgdrvvkldvlctkcrvpsydplkmdevykvilpnflanggd
gfqmikdellrhdsgdqdinvvstyiskmkviypavegrikhh

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6hxwB (B:)
weltilhtndvhsrleqtsedsskcvnasrcmggvarlftkvqqirraepnvllldagdq
yqgtiwftvykgaevahfmnalrydamalgnhefdngvegliepllkeakfpilsanika
kgplasqisglylpykvlpvgdevvgivgytsketpflsnpgtnlvfedeitalqpevdk
lktlnvnkiialghsgfemdkliaqkvrgvdvvvgghsntflytgnppskevpagkypfi
vtsddgrkvpvvqayafgkylgylkiefdergnvisshgnpillnssipedpsikadink
wrikldnystqelgktivyldgssqscrfrecnmgnlicdaminnnlrhtdemfwnhvsm
cilngggirspidernngtitwenlaavlpfggtfdlvqlkgstlkkafehsvhrygqst
geflqvggihvvydlsrkpgdrvvkldvlctkcrvpsydplkmdevykvilpnflanggd
gfqmikdellrhdsgdqdinvvstyiskmkviypavegrikhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6hxwB (B:)
weltilhtndvhsrleqtsedsskcvnasrcmggvarlftkvqqirraepnvllldagdq
yqgtiwftvykgaevahfmnalrydamalgnhefdngvegliepllkeakfpilsanika
kgplasqisglylpykvlpvgdevvgivgytsketpflsnpgtnlvfedeitalqpevdk
lktlnvnkiialghsgfemdkliaqkvrgvdvvvgghsntflytgnppskevpagkypfi
vtsddgrkvpvvqayafgkylgylkiefdergnvisshgnpillnssipedpsikadink
wrikldnystqelgktivyldgssqscrfrecnmgnlicdaminnnlrhtdemfwnhvsm
cilngggirspidernngtitwenlaavlpfggtfdlvqlkgstlkkafehsvhrygqst
geflqvggihvvydlsrkpgdrvvkldvlctkcrvpsydplkmdevykvilpnflanggd
gfqmikdellrhdsgdqdinvvstyiskmkviypavegrikhh

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6hxwC (C:)
qiqlvqsgaevkkpgasvkvsckasgytfasynmywvrqapgqrlewigyidpynggssy
nqkfkgrvtltrdksastaymelsslrsedtavyycargynnykawfaywgqgtlvtvss
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6hxwC (C:)
qiqlvqsgaevkkpgasvkvsckasgytfasynmywvrqapgqrlewigyidpynggssy
nqkfkgrvtltrdksastaymelsslrsedtavyycargynnykawfaywgqgtlvtvss
astkgpsvfplapsstaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysls
svvtvpssslgtqtyicnvnhkpsntkvdkrvepk

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records:
    >6hxwD (D:)
iqmtqspsslsasvgdrvtitckasqsvtndvawyqqkpgkapklliyyasnrytgvpsr
fsgsgygtdftftisslqpediatyycqqdyssltfgqgtkleikrtvaapsvfifppsd
eqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltls
kadyekhkvyacevthqglsspvtksfnr

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6hxwH (H:)
qiqlvqsgaevkkpgasvkvsckasgytfasynmywvrqapgqrlewigyidpynggssy
nqkfkgrvtltrdksastaymelsslrsedtavyycargynnykawfaywgqgtlvtvss
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6hxwH (H:)
qiqlvqsgaevkkpgasvkvsckasgytfasynmywvrqapgqrlewigyidpynggssy
nqkfkgrvtltrdksastaymelsslrsedtavyycargynnykawfaywgqgtlvtvss
astkgpsvfplapsstaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysls
svvtvpssslgtqtyicnvnhkpsntkvdkrvepk

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records:
    >6hxwL (L:)
iqmtqspsslsasvgdrvtitckasqsvtndvawyqqkpgkapklliyyasnrytgvpsr
fsgsgygtdftftisslqpediatyycqqdyssltfgqgtkleikrtvaapsvfifppsd
eqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltls
kadyekhkvyacevthqglsspvtksfnr