PDB entry 6hxf

View 6hxf on RCSB PDB site
Description: Human STK10 bound to a maleimide inhibitor
Class: transferase
Keywords: Kinase, TRANSFERASE
Deposited on 2018-10-17, released 2018-10-31
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-10-31, with a file datestamp of 2018-10-26.
Experiment type: XRAY
Resolution: 2.09 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: serine/threonine-protein kinase 10
    Species: Homo sapiens [TaxId:9606]
    Gene: STK10, LOK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6hxfa_
  • Chain 'B':
    Compound: serine/threonine-protein kinase 10
    Species: Homo sapiens [TaxId:9606]
    Gene: STK10, LOK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6hxfb_
  • Chain 'C':
    Compound: serine/threonine-protein kinase 10
    Species: Homo sapiens [TaxId:9606]
    Gene: STK10, LOK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6hxfc_
  • Chain 'D':
    Compound: serine/threonine-protein kinase 10
    Species: Homo sapiens [TaxId:9606]
    Gene: STK10, LOK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6hxfd_
  • Heterogens: R70, EDO, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6hxfA (A:)
smrksreyehvrrdldpnevweivgelgdgafgkvykaknketgalaaakvietkseeel
edyiveieilatcdhpyivkllgayyhdgklwimiefcpggavdaimleldrgltepqiq
vvcrqmlealnflhskriihrdlkagnvlmtlegdirladfgvsaknlktlqkrdsfigt
pywmapevvmcetmkdtpydykadiwslgitliemaqiepphhelnpmrvllkiaksdpp
tlltpskwsvefrdflkialdknpetrpsaaqllehpfvssitsnkalrelvaeakaevm
ee

    Sequence, based on observed residues (ATOM records): (download) 
    >6hxfA (A:)
ehvrrdldpnevweivgelgdgafgkvykaknketgalaaakvieteeeledyiveieil
atcdhpyivkllgayyhdgklwimiefcpggavdaimleldrgltepqiqvvcrqmleal
nflhskriihrdlkagnvlmtlegdirladfgvsaknlktlqsfigtpywmapevvmcet
mkdtpydykadiwslgitliemaqiepphhelnpmrvllkiaksdpptlltpskwsvefr
dflkialdknpetrpsaaqllehpfvssitsnkalrelvaeakae

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6hxfB (B:)
smrksreyehvrrdldpnevweivgelgdgafgkvykaknketgalaaakvietkseeel
edyiveieilatcdhpyivkllgayyhdgklwimiefcpggavdaimleldrgltepqiq
vvcrqmlealnflhskriihrdlkagnvlmtlegdirladfgvsaknlktlqkrdsfigt
pywmapevvmcetmkdtpydykadiwslgitliemaqiepphhelnpmrvllkiaksdpp
tlltpskwsvefrdflkialdknpetrpsaaqllehpfvssitsnkalrelvaeakaevm
ee

    Sequence, based on observed residues (ATOM records): (download) 
    >6hxfB (B:)
ehvrrdldpnevweivgelgdgafgkvykaknketgalaaakvietkseeeledyiveie
ilatcdhpyivkllgayyhdgklwimiefcpggavdaimleldrgltepqiqvvcrqmle
alnflhskriihrdlkagnvlmtlegdirladfgvsaknlktlqkrdsfigtpywmapev
vmcetmkdtpydykadiwslgitliemaqiepphhelnpmrvllkiaksdpptlltpskw
svefrdflkialdknpetrpsaaqllehpfvssitsnkalrelvaeakaev

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6hxfC (C:)
smrksreyehvrrdldpnevweivgelgdgafgkvykaknketgalaaakvietkseeel
edyiveieilatcdhpyivkllgayyhdgklwimiefcpggavdaimleldrgltepqiq
vvcrqmlealnflhskriihrdlkagnvlmtlegdirladfgvsaknlktlqkrdsfigt
pywmapevvmcetmkdtpydykadiwslgitliemaqiepphhelnpmrvllkiaksdpp
tlltpskwsvefrdflkialdknpetrpsaaqllehpfvssitsnkalrelvaeakaevm
ee

    Sequence, based on observed residues (ATOM records): (download) 
    >6hxfC (C:)
ehvrrdldpnevweivgelgdgafgkvykaknketgalaaakvietkeeeledyiveiei
latcdhpyivkllgayyhdgklwimiefcpggavdaimleldrgltepqiqvvcrqmlea
lnflhskriihrdlkagnvlmtlegdirladfgvsaknlktlqkrdsfigtpywmapevv
mcetmkdtpydykadiwslgitliemaqiepphhelnpmrvllkiaksdpptlltpskws
vefrdflkialdknpetrpsaaqllehpfvssitsnkalrelvaeaka

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6hxfD (D:)
smrksreyehvrrdldpnevweivgelgdgafgkvykaknketgalaaakvietkseeel
edyiveieilatcdhpyivkllgayyhdgklwimiefcpggavdaimleldrgltepqiq
vvcrqmlealnflhskriihrdlkagnvlmtlegdirladfgvsaknlktlqkrdsfigt
pywmapevvmcetmkdtpydykadiwslgitliemaqiepphhelnpmrvllkiaksdpp
tlltpskwsvefrdflkialdknpetrpsaaqllehpfvssitsnkalrelvaeakaevm
ee

    Sequence, based on observed residues (ATOM records): (download) 
    >6hxfD (D:)
yehvrrdldpnevweivgelgdgafgkvykaknketgalaaakvietkseeeledyivei
eilatcdhpyivkllgayyhdgklwimiefcpggavdaimleldrgltepqiqvvcrqml
ealnflhskriihrdlkagnvlmtlegdirladfgvsaknlktlqkrdsfigtpywmape
vvmcedtpydykadiwslgitliemaqiepphhelnpmrvllkiaksdpptlltpskwsv
efrdflkialdknpetrpsaaqllehpfvssitsnkalrelvaeaka