PDB entry 6hx4

View 6hx4 on RCSB PDB site
Description: Fab fragment of a native monomer-selective antibody in complex with alpha-1-antitrypsin
Class: protein binding
Keywords: Antibody fragment, Antitrypsin binding, Diagnostic, Monoclonal, PROTEIN BINDING, conformationally-selective
Deposited on 2018-10-15, released 2019-10-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-10-30, with a file datestamp of 2019-10-25.
Experiment type: XRAY
Resolution: 2.95 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: alpha-1-antitrypsin
    Species: Homo sapiens [TaxId:9606]
    Gene: SERPINA1, AAT, PI, PRO0684, PRO2209
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: alpha-1-antitrypsin
    Species: Homo sapiens [TaxId:9606]
    Gene: SERPINA1, AAT, PI, PRO0684, PRO2209
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: FAB 1D9 heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6HX4 (0-227)
    Domains in SCOPe 2.08: d6hx4h_
  • Chain 'I':
    Compound: FAB 1D9 heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6HX4
    Domains in SCOPe 2.08: d6hx4i_
  • Chain 'L':
    Compound: FAB 1D9 light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6HX4 (0-216)
    Domains in SCOPe 2.08: d6hx4l1, d6hx4l2
  • Chain 'M':
    Compound: FAB 1D9 light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6HX4 (0-End)
    Domains in SCOPe 2.08: d6hx4m1, d6hx4m2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    No sequence available.

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6hx4H (H:)
dvqlvesggglvkpggslklscaasgftfssytmswvrqtpekrlewvatissggdytys
pdsvkgrftisrdnakstlylqmsslksedtamfycsraefittatwgvyamdywgqgts
vtvssakttppsvyplapgsaaqtnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpa
vlqsdlytlsssvtvpsstwpsetvtcnvahpasstkvdkkivprdcd

    Sequence, based on observed residues (ATOM records): (download) 
    >6hx4H (H:)
dvqlvesggglvkpggslklscaasgftfssytmswvrqtpekrlewvatissggdytys
pdsvkgrftisrdnakstlylqmsslksedtamfycsraefittatwgvyamdywgqgts
vtvssakttppsvyplapnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdl
ytlsssvtvpsstwpsetvtcnvahpasstkvdkkivprdcd

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >6hx4I (I:)
dvqlvesggglvkpggslklscaasgftfssytmswvrqtpekrlewvatissggdytys
pdsvkgrftisrdnakstlylqmsslksedtamfycsraefittatwgvyamdywgqgts
vtvssakttppsvyplapgsaaqtnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpa
vlqsdlytlsssvtvpsstwpsetvtcnvahpasstkvdkkivprdcd

    Sequence, based on observed residues (ATOM records): (download) 
    >6hx4I (I:)
vqlvesggglvkpggslklscaasgftfssytmswvrqtpekrlewvatissggdytysp
dsvkgrftisrdnakstlylqmsslksedtamfycsraefittatwgvyamdywgqgtsv
tvssakttppsvyplapsmvtlgclvkgyfpepvtvtwnslssgvhtfpavlsdlytlss
svttvtcnvahpasstkvdkkivp

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6hx4L (L:)
divltqspdslavslgqratiscrasesvdnygisfmnwfqqkpgqppklliyaasnqgs
gvparfsgsgsgtdfslnihpmeeddtamyfcqqskevpwtfgggtkleikradaaptvs
ifppsseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysms
stltltkdeyerhnsytceathktstspivksfnrne

  • Chain 'M':
    Sequence, based on SEQRES records: (download) 
    >6hx4M (M:)
divltqspdslavslgqratiscrasesvdnygisfmnwfqqkpgqppklliyaasnqgs
gvparfsgsgsgtdfslnihpmeeddtamyfcqqskevpwtfgggtkleikradaaptvs
ifppsseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysms
stltltkdeyerhnsytceathktstspivksfnrne

    Sequence, based on observed residues (ATOM records): (download) 
    >6hx4M (M:)
divltqspdslavslgqratiscrasesvdnygisfmnwfqqkpgqppklliyaasnqgs
gvparfsgsgsgtdfslnihpmeeddtamyfcqqskevpwtfgggtkleikradaaptvs
ifppsseqltsggasvvcflnnfypkdinvkwkidgrqngvlnswtdqdskdstysmsst
ltltkdeyerhnsytceathktstivksfn