PDB entry 6hx1

View 6hx1 on RCSB PDB site
Description: ire1 alpha in complex with imidazo[1,2-b]pyridazin-8-amine compound 2
Deposited on 2018-10-15, released 2019-02-27
The last revision was dated 2019-10-30, with a file datestamp of 2019-10-25.
Experiment type: XRAY
Resolution: 2.14 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase/endoribonuclease IRE1
    Species: Homo sapiens [TaxId:9606]
    Gene: ERN1, IRE1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: GXK, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6hx1A (A:)
svvivgkisfcpkdvlghgaegtivyrgmfdnrdvavkrilpecfsfadrevqllresde
hpnviryfctekdrqfqyiaielcaatlqeyveqkdfahlglepitllqqttsglahlhs
lnivhrdlkphnilismpnahgkikamisdfglckklavgrhsfsrrsgvpgtegwiape
mlsedckenptytvdifsagcvfyyvisegshpfgkslqrqanillgacsldclhpekhe
dviareliekmiamdpqkrpsakhvlkhpffwslekqlqffqdvsdriekesldgpivkq
lerggravvkmdwrenitvplqtdlrkfrtykggsvrdllramrnkkhhyrelpaevret
lgslpddfvcyftsrfphllahtyramelcsherlfqpyyfhe

    Sequence, based on observed residues (ATOM records):
    >6hx1A (A:)
svvivgkisfcpkdvlghgaegtivyrgmfdnrdvavkrilpecfresdehpnviryfct
ekdrqfqyiaielcaatlqeyveqkdfahlglepitllqqttsglahlhslnivhrdlkp
hnilismpnahgkikamisdfglckkvgrhsfsrrsgvpgtegwiapemlsenptytvdi
fsagcvfyyvisegshpfgkslqrqanillgacsldclhpekhedviareliekmiamdp
qkrpsakhvlkhpffwslekqlqffqdvsdriekesldgpivkqlerggravvkmdwren
itvplqtdlrkfrtykggsvrdllramrnkkhhyrelpaevretlgslpddfvcyftsrf
phllahtyramelcsherlfqpyyfhe