PDB entry 6hwo

View 6hwo on RCSB PDB site
Description: crystal structure of human phosphodiesterase 4d2 catalytic domain with inhibitor npd-1335
Deposited on 2018-10-12, released 2019-07-24
The last revision was dated 2019-09-04, with a file datestamp of 2019-08-30.
Experiment type: XRAY
Resolution: 1.99 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP-specific 3',5'-cyclic phosphodiesterase 4D
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE4D, DPDE3
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: cAMP-specific 3',5'-cyclic phosphodiesterase 4D
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE4D, DPDE3
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: cAMP-specific 3',5'-cyclic phosphodiesterase 4D
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE4D, DPDE3
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: cAMP-specific 3',5'-cyclic phosphodiesterase 4D
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE4D, DPDE3
    Database cross-references and differences (RAF-indexed):
  • Heterogens: FFZ, EDO, PEG, ZN, MG, EPE, DMS, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6hwoA (A:)
gshmiprfgvkteqedvlakeledvnkwglhvfriaelsgnrpltvimhtifqerdllkt
fkipvdtlitylmtledhyhadvayhnnihaadvvqsthvllstpaleavftdleilaai
fasaihdvdhpgvsnqflintnselalmyndssvlenhhlavgfkllqeencdifqnltk
kqrqslrkmvidivlatdmskhmnlladlktmvetkkvtssgvllldnysdriqvlqnmv
hcadlsnptkplqlyrqwtdrimeeffrqgdrerergmeispmcdkhnasveksqvgfid
yivhplwetwadlvhpdaqdildtlednrewyqstipqspspapddpeegrqgqtekfqf
eltl

    Sequence, based on observed residues (ATOM records):
    >6hwoA (A:)
gvkteqedvlakeledvnkwglhvfriaelsgnrpltvimhtifqerdllktfkipvdtl
itylmtledhyhadvayhnnihaadvvqsthvllstpaleavftdleilaaifasaihdv
dhpgvsnqflintnselalmyndssvlenhhlavgfkllqeencdifqnltkkqrqslrk
mvidivlatdmskhmnlladlktmvetkkvtssgvllldnysdriqvlqnmvhcadlsnp
tkplqlyrqwtdrimeeffrqgdrerergmeispmcdkhnasveksqvgfidyivhplwe
twadlvhpdaqdildtlednrewyqst

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6hwoB (B:)
gshmiprfgvkteqedvlakeledvnkwglhvfriaelsgnrpltvimhtifqerdllkt
fkipvdtlitylmtledhyhadvayhnnihaadvvqsthvllstpaleavftdleilaai
fasaihdvdhpgvsnqflintnselalmyndssvlenhhlavgfkllqeencdifqnltk
kqrqslrkmvidivlatdmskhmnlladlktmvetkkvtssgvllldnysdriqvlqnmv
hcadlsnptkplqlyrqwtdrimeeffrqgdrerergmeispmcdkhnasveksqvgfid
yivhplwetwadlvhpdaqdildtlednrewyqstipqspspapddpeegrqgqtekfqf
eltl

    Sequence, based on observed residues (ATOM records):
    >6hwoB (B:)
vlakeledvnkwglhvfriaelsgnrpltvimhtifqerdllktfkipvdtlitylmtle
dhyhadvayhnnihaadvvqsthvllstpaleavftdleilaaifasaihdvdhpgvsnq
flintnselalmyndssvlenhhlavgfkllqeencdifqnltkkqrqslrkmvidivla
tdmskhmnlladlktmvetkkvtssgvllldnysdriqvlqnmvhcadlsnptkplqlyr
qwtdrimeeffrqgdrerergmeispmcdkhnasveksqvgfidyivhplwetwadlvhp
daqdildtlednrewyqstip

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6hwoC (C:)
gshmiprfgvkteqedvlakeledvnkwglhvfriaelsgnrpltvimhtifqerdllkt
fkipvdtlitylmtledhyhadvayhnnihaadvvqsthvllstpaleavftdleilaai
fasaihdvdhpgvsnqflintnselalmyndssvlenhhlavgfkllqeencdifqnltk
kqrqslrkmvidivlatdmskhmnlladlktmvetkkvtssgvllldnysdriqvlqnmv
hcadlsnptkplqlyrqwtdrimeeffrqgdrerergmeispmcdkhnasveksqvgfid
yivhplwetwadlvhpdaqdildtlednrewyqstipqspspapddpeegrqgqtekfqf
eltl

    Sequence, based on observed residues (ATOM records):
    >6hwoC (C:)
eqedvlakeledvnkwglhvfriaelsgnrpltvimhtifqerdllktfkipvdtlityl
mtledhyhadvayhnnihaadvvqsthvllstpaleavftdleilaaifasaihdvdhpg
vsnqflintnselalmyndssvlenhhlavgfkllqeencdifqnltkkqrqslrkmvid
ivlatdmskhmnlladlktmvetkkvtssgvllldnysdriqvlqnmvhcadlsnptkpl
qlyrqwtdrimeeffrqgdrerergmeispmcdkhnasveksqvgfidyivhplwetwad
lvhpdaqdildtlednrewyqsti

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6hwoD (D:)
gshmiprfgvkteqedvlakeledvnkwglhvfriaelsgnrpltvimhtifqerdllkt
fkipvdtlitylmtledhyhadvayhnnihaadvvqsthvllstpaleavftdleilaai
fasaihdvdhpgvsnqflintnselalmyndssvlenhhlavgfkllqeencdifqnltk
kqrqslrkmvidivlatdmskhmnlladlktmvetkkvtssgvllldnysdriqvlqnmv
hcadlsnptkplqlyrqwtdrimeeffrqgdrerergmeispmcdkhnasveksqvgfid
yivhplwetwadlvhpdaqdildtlednrewyqstipqspspapddpeegrqgqtekfqf
eltl

    Sequence, based on observed residues (ATOM records):
    >6hwoD (D:)
qedvlakeledvnkwglhvfriaelsgnrpltvimhtifqerdllktfkipvdtlitylm
tledhyhadvayhnnihaadvvqsthvllstpaleavftdleilaaifasaihdvdhpgv
snqflintnselalmyndssvlenhhlavgfkllqeencdifqnltkkqrqslrkmvidi
vlatdmskhmnlladlktmvetkkvtssgvllldnysdriqvlqnmvhcadlsnptkplq
lyrqwtdrimeeffrqgdrerergmeispmcdkhnasveksqvgfidyivhplwetwadl
vhpdaqdildtlednrewyqstip