PDB entry 6hwm

View 6hwm on RCSB PDB site
Description: Structure of Thermus thermophilus ClpP in complex with bortezomib
Class: hydrolase
Keywords: hydrolase, complex, activator
Deposited on 2018-10-12, released 2019-09-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-09-25, with a file datestamp of 2019-09-20.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ATP-dependent Clp protease proteolytic subunit
    Species: Thermus thermophilus [TaxId:274]
    Gene: clpP, TT_C0250
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6hwma_
  • Chain 'B':
    Compound: ATP-dependent Clp protease proteolytic subunit
    Species: Thermus thermophilus [TaxId:274]
    Gene: clpP, TT_C0250
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q72L15 (Start-193)
      • expression tag (194-200)
    Domains in SCOPe 2.08: d6hwmb1, d6hwmb2
  • Chain 'C':
    Compound: ATP-dependent Clp protease proteolytic subunit
    Species: Thermus thermophilus [TaxId:274]
    Gene: clpP, TT_C0250
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6hwmc_
  • Chain 'D':
    Compound: ATP-dependent Clp protease proteolytic subunit
    Species: Thermus thermophilus [TaxId:274]
    Gene: clpP, TT_C0250
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6hwmd_
  • Chain 'E':
    Compound: ATP-dependent Clp protease proteolytic subunit
    Species: Thermus thermophilus [TaxId:274]
    Gene: clpP, TT_C0250
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q72L15 (0-193)
      • expression tag (194-200)
    Domains in SCOPe 2.08: d6hwme1, d6hwme2
  • Chain 'F':
    Compound: ATP-dependent Clp protease proteolytic subunit
    Species: Thermus thermophilus [TaxId:274]
    Gene: clpP, TT_C0250
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q72L15 (Start-193)
      • expression tag (194-195)
    Domains in SCOPe 2.08: d6hwmf1, d6hwmf2
  • Chain 'G':
    Compound: ATP-dependent Clp protease proteolytic subunit
    Species: Thermus thermophilus [TaxId:274]
    Gene: clpP, TT_C0250
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6hwmg_
  • Heterogens: BO2, PEG

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6hwmA (A:)
mvipyvieqtargervydiysrllkdriiflgtpidaqvanvvvaqllfldaqnpnqeik
lyinspggevdaglaiydtmqfvrapvstivigmaasmaavilaagekgrryalphakvm
ihqpwggvrgtasdiaiqaqeilkakkllneilakhtgqplekvekdtdrdyylsaqeal
eyglidqvvtreealehhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6hwmA (A:)
ipyvieqvydiysrllkdriiflgtpidaqvanvvvaqllfldaqnpnqeiklyinspgg
evdaglaiydtmqfvrapvstivigmaasmaavilaagekgrryalphakvmihqpwggv
rgtasdiaiqaqeilkakkllneilakhtgqplekvekdtdrdyylsaqealeyglidqv
vtree

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6hwmB (B:)
mvipyvieqtargervydiysrllkdriiflgtpidaqvanvvvaqllfldaqnpnqeik
lyinspggevdaglaiydtmqfvrapvstivigmaasmaavilaagekgrryalphakvm
ihqpwggvrgtasdiaiqaqeilkakkllneilakhtgqplekvekdtdrdyylsaqeal
eyglidqvvtreealehhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6hwmB (B:)
ipyvirvydiysrllkdriiflgtpidaqvanvvvaqllfldaqnpnqeiklyinspgge
vdaglaiydtmqfvrapvstivigmaasmaavilaagekgrryalphakvmihqpwggvr
gtasdiaiqaqeilkakkllneilakhtgqplekvekdtdrdyylsaqealeyglidqvv
treealehhhhh

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6hwmC (C:)
mvipyvieqtargervydiysrllkdriiflgtpidaqvanvvvaqllfldaqnpnqeik
lyinspggevdaglaiydtmqfvrapvstivigmaasmaavilaagekgrryalphakvm
ihqpwggvrgtasdiaiqaqeilkakkllneilakhtgqplekvekdtdrdyylsaqeal
eyglidqvvtreealehhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6hwmC (C:)
vipyviydiysrllkdriiflgtpidaqvanvvvaqllfldaqnpnqeiklyinspggev
daglaiydtmqfvrapvstivigmaasmaavilaagekgrryalphakvmihqpwggvrg
tasdiaiqaqeilkakkllneilakhtgqplekvekdtdrdyylsaqealeyglidqvvt
ree

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6hwmD (D:)
mvipyvieqtargervydiysrllkdriiflgtpidaqvanvvvaqllfldaqnpnqeik
lyinspggevdaglaiydtmqfvrapvstivigmaasmaavilaagekgrryalphakvm
ihqpwggvrgtasdiaiqaqeilkakkllneilakhtgqplekvekdtdrdyylsaqeal
eyglidqvvtreealehhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6hwmD (D:)
vipyvieydiysrllkdriiflgtpidaqvanvvvaqllfldaqnpnqeiklyinspgge
vdaglaiydtmqfvrapvstivigmaasmaavilaagekgrryalphakvmihqpwggvr
gtasdiaiqaqeilkakkllneilakhtgqplekvekdtdrdyylsaqealeyglidqvv
tree

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6hwmE (E:)
mvipyvieqtargervydiysrllkdriiflgtpidaqvanvvvaqllfldaqnpnqeik
lyinspggevdaglaiydtmqfvrapvstivigmaasmaavilaagekgrryalphakvm
ihqpwggvrgtasdiaiqaqeilkakkllneilakhtgqplekvekdtdrdyylsaqeal
eyglidqvvtreealehhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6hwmE (E:)
mvipyviervydiysrllkdriiflgtpidaqvanvvvaqllfldaqnpnqeiklyinsp
ggevdaglaiydtmqfvrapvstivigmaasmaavilaagekgrryalphakvmihqpwg
gvrgtasdiaiqaqeilkakkllneilakhtgqplekvekdtdrdyylsaqealeyglid
qvvtreealehhhhh

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6hwmF (F:)
mvipyvieqtargervydiysrllkdriiflgtpidaqvanvvvaqllfldaqnpnqeik
lyinspggevdaglaiydtmqfvrapvstivigmaasmaavilaagekgrryalphakvm
ihqpwggvrgtasdiaiqaqeilkakkllneilakhtgqplekvekdtdrdyylsaqeal
eyglidqvvtreealehhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6hwmF (F:)
vipyviervydiysrllkdriiflgtpidaqvanvvvaqllfldaqnpnqeiklyinspg
gevdaglaiydtmqfvrapvstivigmaasmaavilaagekgrryalphakvmihqpwgg
vrgtasdiaiqaqeilkakkllneilakhtgqplekvekdtdrdyylsaqealeyglidq
vvtreeale

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6hwmG (G:)
mvipyvieqtargervydiysrllkdriiflgtpidaqvanvvvaqllfldaqnpnqeik
lyinspggevdaglaiydtmqfvrapvstivigmaasmaavilaagekgrryalphakvm
ihqpwggvrgtasdiaiqaqeilkakkllneilakhtgqplekvekdtdrdyylsaqeal
eyglidqvvtreealehhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6hwmG (G:)
vipyvvydiysrllkdriiflgtpidaqvanvvvaqllfldaqnpnqeiklyinspggev
daglaiydtmqfvrapvstivigmaasmaavilaagekgrryalphakvmihqpwggvrg
tasdiaiqaqeilkakkllneilakhtgqplekvekdtdrdyylsaqealeyglidqvvt
ree