PDB entry 6hvf

View 6hvf on RCSB PDB site
Description: Kinase domain of cSrc in complex with compound 29B
Class: transferase
Keywords: Kinase inhibitor, covalent inhibitor, TRANSFERASE
Deposited on 2018-10-10, released 2019-10-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-01, with a file datestamp of 2019-12-27.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Gallus gallus [TaxId:9031]
    Gene: SRC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00523 (Start-285)
      • engineered mutation (90)
      • engineered mutation (97)
    Domains in SCOPe 2.08: d6hvfa_
  • Chain 'B':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Gallus gallus [TaxId:9031]
    Gene: SRC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00523 (Start-285)
      • engineered mutation (90)
      • engineered mutation (97)
    Domains in SCOPe 2.08: d6hvfb_
  • Heterogens: GUT, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6hvfA (A:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivmeymskgclldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl

    Sequence, based on observed residues (ATOM records): (download) 
    >6hvfA (A:)
kdaweipreslrlevklgqggevwmgtwngttrvaiktflqeaqvmkklrheklvqlyav
vseepiyivmeymskgclldflkgemgkylrlpqlvdmaaqiasgmayvermnyvhrdlr
aanilvgenlvckvadfpikwtapeaalygrftiksdvwsfgilltelttkgrvpypgmv
nrevldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqafledyftstepqy
qpgenl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6hvfB (B:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivmeymskgclldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl

    Sequence, based on observed residues (ATOM records): (download) 
    >6hvfB (B:)
daweipreslrlevklgqggevwmgtwngttrvaiktlkqeaqvmkklrheklvqlyavv
seepiyivmeymskgclldflkgemgkylrlpqlvdmaaqiasgmayvermnyvhrdlra
anilvgenlvckvadpikwtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnr
evldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqafledyftstepqyqp
genl