PDB entry 6huf

View 6huf on RCSB PDB site
Description: Coping with strong translational non-crystallographic symmetry and extreme anisotropy in molecular replacement with Phaser: human Rab27a
Class: exocytosis
Keywords: GTPase, Exocytosis, Vesicle transport
Deposited on 2018-10-08, released 2019-03-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-07-10, with a file datestamp of 2019-07-05.
Experiment type: XRAY
Resolution: 2.82 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ras-related protein Rab-27A
    Species: Homo sapiens [TaxId:9606]
    Gene: RAB27A, RAB27
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51159
      • conflict (49-50)
      • conflict (53-55)
      • conflict (58)
      • conflict (67)
      • conflict (94)
      • conflict (107-108)
      • conflict (112)
      • conflict (129)
      • conflict (133-135)
      • conflict (138-139)
      • conflict (143)
      • conflict (177)
    Domains in SCOPe 2.08: d6hufa_
  • Chain 'B':
    Compound: Ras-related protein Rab-27A
    Species: Homo sapiens [TaxId:9606]
    Gene: RAB27A, RAB27
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51159
      • conflict (49-50)
      • conflict (53-55)
      • conflict (58)
      • conflict (67)
      • conflict (94)
      • conflict (107-108)
      • conflict (112)
      • conflict (129)
      • conflict (133-135)
      • conflict (138-139)
      • conflict (143)
      • conflict (177)
    Domains in SCOPe 2.08: d6hufb_
  • Chain 'C':
    Compound: Ras-related protein Rab-27A
    Species: Homo sapiens [TaxId:9606]
    Gene: RAB27A, RAB27
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51159
      • conflict (49-50)
      • conflict (53-55)
      • conflict (58)
      • conflict (67)
      • conflict (94)
      • conflict (107-108)
      • conflict (112)
      • conflict (129)
      • conflict (133-135)
      • conflict (138-139)
      • conflict (143)
      • conflict (177)
    Domains in SCOPe 2.08: d6hufc_
  • Chain 'D':
    Compound: Ras-related protein Rab-27A
    Species: Homo sapiens [TaxId:9606]
    Gene: RAB27A, RAB27
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51159
      • conflict (49-50)
      • conflict (53-55)
      • conflict (58)
      • conflict (67)
      • conflict (94)
      • conflict (107-108)
      • conflict (112)
      • conflict (129)
      • conflict (133-135)
      • conflict (138-139)
      • conflict (143)
      • conflict (177)
    Domains in SCOPe 2.08: d6hufd_
  • Chain 'E':
    Compound: Ras-related protein Rab-27A
    Species: Homo sapiens [TaxId:9606]
    Gene: RAB27A, RAB27
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51159
      • conflict (49-50)
      • conflict (53-55)
      • conflict (58)
      • conflict (67)
      • conflict (94)
      • conflict (107-108)
      • conflict (112)
      • conflict (129)
      • conflict (133-135)
      • conflict (138-139)
      • conflict (143)
      • conflict (177)
    Domains in SCOPe 2.08: d6hufe_
  • Chain 'F':
    Compound: Ras-related protein Rab-27A
    Species: Homo sapiens [TaxId:9606]
    Gene: RAB27A, RAB27
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51159
      • conflict (49-50)
      • conflict (53-55)
      • conflict (58)
      • conflict (67)
      • conflict (94)
      • conflict (107-108)
      • conflict (112)
      • conflict (129)
      • conflict (133-135)
      • conflict (138-139)
      • conflict (143)
      • conflict (177)
    Domains in SCOPe 2.08: d6huff_
  • Chain 'G':
    Compound: Ras-related protein Rab-27A
    Species: Homo sapiens [TaxId:9606]
    Gene: RAB27A, RAB27
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51159
      • conflict (49-50)
      • conflict (53-55)
      • conflict (58)
      • conflict (67)
      • conflict (94)
      • conflict (107-108)
      • conflict (112)
      • conflict (129)
      • conflict (133-135)
      • conflict (138-139)
      • conflict (143)
      • conflict (177)
    Domains in SCOPe 2.08: d6hufg_
  • Chain 'H':
    Compound: Ras-related protein Rab-27A
    Species: Homo sapiens [TaxId:9606]
    Gene: RAB27A, RAB27
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51159
      • conflict (49-50)
      • conflict (53-55)
      • conflict (58)
      • conflict (67)
      • conflict (94)
      • conflict (107-108)
      • conflict (112)
      • conflict (129)
      • conflict (133-135)
      • conflict (138-139)
      • conflict (143)
      • conflict (177)
    Domains in SCOPe 2.08: d6hufh_
  • Chain 'I':
    Compound: Ras-related protein Rab-27A
    Species: Homo sapiens [TaxId:9606]
    Gene: RAB27A, RAB27
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51159
      • conflict (49-50)
      • conflict (53-55)
      • conflict (58)
      • conflict (67)
      • conflict (94)
      • conflict (107-108)
      • conflict (112)
      • conflict (129)
      • conflict (133-135)
      • conflict (138-139)
      • conflict (143)
      • conflict (177)
    Domains in SCOPe 2.08: d6hufi_
  • Chain 'J':
    Compound: Ras-related protein Rab-27A
    Species: Homo sapiens [TaxId:9606]
    Gene: RAB27A, RAB27
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51159
      • conflict (49-50)
      • conflict (53-55)
      • conflict (58)
      • conflict (67)
      • conflict (94)
      • conflict (107-108)
      • conflict (112)
      • conflict (129)
      • conflict (133-135)
      • conflict (138-139)
      • conflict (143)
      • conflict (177)
    Domains in SCOPe 2.08: d6hufj_
  • Chain 'K':
    Compound: Ras-related protein Rab-27A
    Species: Homo sapiens [TaxId:9606]
    Gene: RAB27A, RAB27
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51159
      • conflict (49-50)
      • conflict (53-55)
      • conflict (58)
      • conflict (67)
      • conflict (94)
      • conflict (107-108)
      • conflict (112)
      • conflict (129)
      • conflict (133-135)
      • conflict (138-139)
      • conflict (143)
      • conflict (177)
    Domains in SCOPe 2.08: d6hufk_
  • Chain 'L':
    Compound: Ras-related protein Rab-27A
    Species: Homo sapiens [TaxId:9606]
    Gene: RAB27A, RAB27
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51159
      • conflict (49-50)
      • conflict (53-55)
      • conflict (58)
      • conflict (67)
      • conflict (94)
      • conflict (107-108)
      • conflict (112)
      • conflict (129)
      • conflict (133-135)
      • conflict (138-139)
      • conflict (143)
      • conflict (177)
    Domains in SCOPe 2.08: d6hufl_
  • Chain 'M':
    Compound: Ras-related protein Rab-27A
    Species: Homo sapiens [TaxId:9606]
    Gene: RAB27A, RAB27
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51159
      • conflict (49-50)
      • conflict (53-55)
      • conflict (58)
      • conflict (67)
      • conflict (94)
      • conflict (107-108)
      • conflict (112)
      • conflict (129)
      • conflict (133-135)
      • conflict (138-139)
      • conflict (143)
      • conflict (177)
    Domains in SCOPe 2.08: d6hufm_
  • Chain 'N':
    Compound: Ras-related protein Rab-27A
    Species: Homo sapiens [TaxId:9606]
    Gene: RAB27A, RAB27
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51159
      • conflict (49-50)
      • conflict (53-55)
      • conflict (58)
      • conflict (67)
      • conflict (94)
      • conflict (107-108)
      • conflict (112)
      • conflict (129)
      • conflict (133-135)
      • conflict (138-139)
      • conflict (143)
      • conflict (177)
    Domains in SCOPe 2.08: d6hufn_
  • Chain 'O':
    Compound: Ras-related protein Rab-27A
    Species: Homo sapiens [TaxId:9606]
    Gene: RAB27A, RAB27
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51159
      • conflict (49-50)
      • conflict (53-55)
      • conflict (58)
      • conflict (67)
      • conflict (94)
      • conflict (107-108)
      • conflict (112)
      • conflict (129)
      • conflict (133-135)
      • conflict (138-139)
      • conflict (143)
      • conflict (177)
    Domains in SCOPe 2.08: d6hufo_
  • Chain 'P':
    Compound: Ras-related protein Rab-27A
    Species: Homo sapiens [TaxId:9606]
    Gene: RAB27A, RAB27
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51159
      • conflict (49-50)
      • conflict (53-55)
      • conflict (58)
      • conflict (67)
      • conflict (94)
      • conflict (107-108)
      • conflict (112)
      • conflict (129)
      • conflict (133-135)
      • conflict (138-139)
      • conflict (143)
      • conflict (177)
    Domains in SCOPe 2.08: d6hufp_
  • Heterogens: MG, GNP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6hufA (A:)
gsdgdydylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkrikl
qlwdtaglerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivl
cgnksdledervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmersvd
ks

    Sequence, based on observed residues (ATOM records): (download) 
    >6hufA (A:)
ylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkriklqlwdtag
lerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivlcgnksdl
edervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmers

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6hufB (B:)
gsdgdydylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkrikl
qlwdtaglerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivl
cgnksdledervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmersvd
ks

    Sequence, based on observed residues (ATOM records): (download) 
    >6hufB (B:)
ylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkriklqlwdtag
lerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivlcgnksdl
edervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmers

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6hufC (C:)
gsdgdydylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkrikl
qlwdtaglerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivl
cgnksdledervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmersvd
ks

    Sequence, based on observed residues (ATOM records): (download) 
    >6hufC (C:)
ylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkriklqlwdtag
lerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivlcgnksdl
edervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmers

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6hufD (D:)
gsdgdydylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkrikl
qlwdtaglerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivl
cgnksdledervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmersvd
ks

    Sequence, based on observed residues (ATOM records): (download) 
    >6hufD (D:)
ylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkriklqlwdtag
lerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivlcgnksdl
edervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmers

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6hufE (E:)
gsdgdydylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkrikl
qlwdtaglerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivl
cgnksdledervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmersvd
ks

    Sequence, based on observed residues (ATOM records): (download) 
    >6hufE (E:)
ylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkriklqlwdtag
lerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivlcgnksdl
edervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmers

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6hufF (F:)
gsdgdydylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkrikl
qlwdtaglerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivl
cgnksdledervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmersvd
ks

    Sequence, based on observed residues (ATOM records): (download) 
    >6hufF (F:)
ylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkriklqlwdtag
lerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivlcgnksdl
edervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmers

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6hufG (G:)
gsdgdydylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkrikl
qlwdtaglerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivl
cgnksdledervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmersvd
ks

    Sequence, based on observed residues (ATOM records): (download) 
    >6hufG (G:)
ylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkriklqlwdtag
lerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivlcgnksdl
edervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmers

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6hufH (H:)
gsdgdydylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkrikl
qlwdtaglerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivl
cgnksdledervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmersvd
ks

    Sequence, based on observed residues (ATOM records): (download) 
    >6hufH (H:)
ylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkriklqlwdtag
lerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivlcgnksdl
edervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmers

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >6hufI (I:)
gsdgdydylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkrikl
qlwdtaglerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivl
cgnksdledervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmersvd
ks

    Sequence, based on observed residues (ATOM records): (download) 
    >6hufI (I:)
ylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkriklqlwdtag
lerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivlcgnksdl
edervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmers

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >6hufJ (J:)
gsdgdydylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkrikl
qlwdtaglerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivl
cgnksdledervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmersvd
ks

    Sequence, based on observed residues (ATOM records): (download) 
    >6hufJ (J:)
ylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkriklqlwdtag
lerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivlcgnksdl
edervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmers

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >6hufK (K:)
gsdgdydylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkrikl
qlwdtaglerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivl
cgnksdledervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmersvd
ks

    Sequence, based on observed residues (ATOM records): (download) 
    >6hufK (K:)
ylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkriklqlwdtag
lerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivlcgnksdl
edervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmers

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6hufL (L:)
gsdgdydylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkrikl
qlwdtaglerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivl
cgnksdledervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmersvd
ks

    Sequence, based on observed residues (ATOM records): (download) 
    >6hufL (L:)
ylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkriklqlwdtag
lerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivlcgnksdl
edervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmers

  • Chain 'M':
    Sequence, based on SEQRES records: (download) 
    >6hufM (M:)
gsdgdydylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkrikl
qlwdtaglerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivl
cgnksdledervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmersvd
ks

    Sequence, based on observed residues (ATOM records): (download) 
    >6hufM (M:)
ylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkriklqlwdtag
lerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivlcgnksdl
edervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmers

  • Chain 'N':
    Sequence, based on SEQRES records: (download) 
    >6hufN (N:)
gsdgdydylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkrikl
qlwdtaglerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivl
cgnksdledervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmersvd
ks

    Sequence, based on observed residues (ATOM records): (download) 
    >6hufN (N:)
ylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkriklqlwdtag
lerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivlcgnksdl
edervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmers

  • Chain 'O':
    Sequence, based on SEQRES records: (download) 
    >6hufO (O:)
gsdgdydylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkrikl
qlwdtaglerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivl
cgnksdledervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmersvd
ks

    Sequence, based on observed residues (ATOM records): (download) 
    >6hufO (O:)
ylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkriklqlwdtag
lerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivlcgnksdl
edervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmers

  • Chain 'P':
    Sequence, based on SEQRES records: (download) 
    >6hufP (P:)
gsdgdydylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkrikl
qlwdtaglerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivl
cgnksdledervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmersvd
ks

    Sequence, based on observed residues (ATOM records): (download) 
    >6hufP (P:)
ylikflalgdsgvgktsvlyqytdgkfnskfittvgidfrektiyrndkriklqlwdtag
lerfrslttaffrdamgflllfdltneesflnvrnwisqlkthaysenpdivlcgnksdl
edervvaaaearqlaehygipyfetsaangtnisqaiemlldlimkrmers