PDB entry 6hti

View 6hti on RCSB PDB site
Description: crystal structure of schistosoma mansoni hdac8 complexed with a benzohydroxamate inhibitor 6
Deposited on 2018-10-04, released 2018-10-31
The last revision was dated 2018-11-28, with a file datestamp of 2018-11-23.
Experiment type: XRAY
Resolution: 1.69 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone deacetylase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: HDAC8
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Histone deacetylase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: HDAC8
    Database cross-references and differences (RAF-indexed):
    • Uniprot A5H660 (Start-440)
      • expression tag (441-446)
  • Chain 'C':
    Compound: Histone deacetylase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: HDAC8
    Database cross-references and differences (RAF-indexed):
    • Uniprot A5H660 (Start-440)
      • expression tag (441-446)
  • Chain 'D':
    Compound: Histone deacetylase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: HDAC8
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ZN, K, GOL, GQW, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6htiA (A:)
hmsvgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeav
tafhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgsl
aaasalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstppetspnrqtr
vlyvdldlhhgdgveeafwysprvvtfsvhhaspgffpgtgtwnmvdndklpiflngagr
grfsafnlpleegindldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltn
fypnlnldsdcdsecslsgylyaikkilswkvptlilggggynfpdtarlwtrvtaltie
evkgkkmtispeipehsyfsrygpdfeldidyfpheshnktldsiqkhhrrileqlrnya
dlnkliydydqvyqlynltgmgslvpr

    Sequence, based on observed residues (ATOM records):
    >6htiA (A:)
svgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeavta
fhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgslaa
asalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstrvlyvdldlhhgd
gveeafwysprvvtfsvhhaspgffpgtgtwnmklpiflngagrgrfsafnlpleegind
ldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltnfyplsgylyaikkils
wkvptlilggggynfpdtarlwtrvtaltieevkgkkmtispeipehsyfsrygpdfeld
idyfpdsiqkhhrrileqlrnyadlnkliydydqvyqly

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6htiB (B:)
hmsvgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeav
tafhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgsl
aaasalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstppetspnrqtr
vlyvdldlhhgdgveeafwysprvvtfsvhhaspgffpgtgtwnmvdndklpiflngagr
grfsafnlpleegindldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltn
fypnlnldsdcdsecslsgylyaikkilswkvptlilggggynfpdtarlwtrvtaltie
evkgkkmtispeipehsyfsrygpdfeldidyfpheshnktldsiqkhhrrileqlrnya
dlnkliydydqvyqlynltgmgslvpr

    Sequence, based on observed residues (ATOM records):
    >6htiB (B:)
svgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeavta
fhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgslaa
asalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvssttrvlyvdldlhhg
dgveeafwysprvvtfsvhhaspgffpgtgtwnlpiflngagrgrfsafnlpleegindl
dwsnaigpildslniviqpsyvvvqcgadclatdphrifrltnfypslsgylyaikkils
wkvptlilggggynfpdtarlwtrvtaltieevkgkkmtispeipehsyfsrygpdfeld
idyfphedsiqkhhrrileqlrnyadlnkliydydqvyqlynltgmgslvpr

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6htiC (C:)
hmsvgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeav
tafhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgsl
aaasalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstppetspnrqtr
vlyvdldlhhgdgveeafwysprvvtfsvhhaspgffpgtgtwnmvdndklpiflngagr
grfsafnlpleegindldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltn
fypnlnldsdcdsecslsgylyaikkilswkvptlilggggynfpdtarlwtrvtaltie
evkgkkmtispeipehsyfsrygpdfeldidyfpheshnktldsiqkhhrrileqlrnya
dlnkliydydqvyqlynltgmgslvpr

    Sequence, based on observed residues (ATOM records):
    >6htiC (C:)
svgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeavta
fhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgslaa
asalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstqtrvlyvdldlhh
gdgveeafwysprvvtfsvhhaspgffpgtgtwnklpiflngagrgrfsafnlpleegin
dldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltnfyplsgylyaikkil
swkvptlilggggynfpdtarlwtrvtaltieevkgkkmtispeipehsyfsrygpdfel
didyfphdsiqkhhrrileqlrnyadlnkliydydqvyqlynltgmgslvpr

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6htiD (D:)
hmsvgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeav
tafhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgsl
aaasalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstppetspnrqtr
vlyvdldlhhgdgveeafwysprvvtfsvhhaspgffpgtgtwnmvdndklpiflngagr
grfsafnlpleegindldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltn
fypnlnldsdcdsecslsgylyaikkilswkvptlilggggynfpdtarlwtrvtaltie
evkgkkmtispeipehsyfsrygpdfeldidyfpheshnktldsiqkhhrrileqlrnya
dlnkliydydqvyqlynltgmgslvpr

    Sequence, based on observed residues (ATOM records):
    >6htiD (D:)
svgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeavta
fhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgslaa
asalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvssqtrvlyvdldlhhg
dgveeafwysprvvtfsvhhaspgffpgtgtwnmpiflngagrgrfsafnlpleegindl
dwsnaigpildslniviqpsyvvvqcgadclatdphrifrltnfypslsgylyaikkils
wkvptlilggggynfpdtarlwtrvtaltieevkgkkmtispeipehsyfsrygpdfeld
idyfpdsiqkhhrrileqlrnyadlnkliydydqvyqly