PDB entry 6hsk

View 6hsk on RCSB PDB site
Description: Crystal structure of a human HDAC8 L6 loop mutant complexed with Quisinostat
Class: hydrolase
Keywords: Epigenetics, Histone deacetylase, HDAC8, Selective inhibitor, hydrolase
Deposited on 2018-10-01, released 2018-10-31
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-11-28, with a file datestamp of 2018-11-23.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone deacetylase 8
    Species: Homo sapiens [TaxId:9606]
    Gene: HDAC8, HDACL1, CDA07
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9BY41 (Start-379)
      • conflict (272)
      • conflict (275-278)
    Domains in SCOPe 2.08: d6hska_
  • Chain 'B':
    Compound: Histone deacetylase 8
    Species: Homo sapiens [TaxId:9606]
    Gene: HDAC8, HDACL1, CDA07
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9BY41 (Start-379)
      • conflict (272)
      • conflict (275-278)
    Domains in SCOPe 2.08: d6hskb_
  • Heterogens: ZN, K, GOK, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6hskA (A:)
gshmeepeepadsgqslvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmriv
kpkvasmeematfhtdaylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaigg
atitaaqclidgmckvainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdl
dlhhgdgvedafsftskvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqd
ekyyqicesvlkevyqafnpkavvlqlgadtisgdrlgcfnmtpvgigkclkyilqwqla
tlilggggynlantarcwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrn
ephriqqilnyikgnlkhvv

    Sequence, based on observed residues (ATOM records): (download) 
    >6hskA (A:)
lvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpkvasmeematfhtd
aylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaiggatitaaqclidgmckv
ainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlhhgdgvedafsfts
kvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdekyyqicesvlkevyq
afnpkavvlqlgadtisgdrlgcfnmtpvgigkclkyilqwqlatlilggggynlantar
cwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrnephriqqilnyikgnl
khvv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6hskB (B:)
gshmeepeepadsgqslvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmriv
kpkvasmeematfhtdaylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaigg
atitaaqclidgmckvainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdl
dlhhgdgvedafsftskvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqd
ekyyqicesvlkevyqafnpkavvlqlgadtisgdrlgcfnmtpvgigkclkyilqwqla
tlilggggynlantarcwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrn
ephriqqilnyikgnlkhvv

    Sequence, based on observed residues (ATOM records): (download) 
    >6hskB (B:)
lvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpkvasmeematfhtd
aylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaiggatitaaqclidgmckv
ainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlhhgdgvedafsfts
kvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdekyyqicesvlkevyq
afnpkavvlqlgadtisgdrlgcfnmtpvgigkclkyilqwqlatlilggggynlantar
cwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrnephriqqilnyikgnl
khvv