PDB entry 6hs4

View 6hs4 on RCSB PDB site
Description: Crystal structure of Ebolavirus glycoprotein in complex with inhibitor 118
Class: viral protein
Keywords: Ebola Glycoprotein, Structure-based In Silico Screening, compound 118, compound 118a, Natural compound, VIRAL PROTEIN
Deposited on 2018-09-28, released 2019-02-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Envelope glycoprotein,GP1,Envelope glycoprotein
    Species: Zaire ebolavirus (strain Mayinga-76) [TaxId:128952]
    Gene: GP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q05320 (4-283)
      • expression tag (2-3)
      • engineered mutation (14)
    • PDB 6HS4 (284-291)
    • Uniprot Q05320
    Domains in SCOPe 2.08: d6hs4a1, d6hs4a2
  • Chain 'B':
    Compound: Envelope glycoprotein
    Species: Zaire ebolavirus [TaxId:128952]
    Gene: GP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q05320 (0-End)
      • engineered mutation (111)
  • Heterogens: NAG, GOL, GON, DMS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6hs4A (A:)
etgrsiplgvihnsalqvsdvdklvcrdklsstnqlrsvglnlegngvatdvpsatkrwg
frsgvppkvvnyeagewaencynleikkpdgseclpaapdgirgfprcryvhkvsgtgpc
agdfafhkegafflydrlastviyrgttfaegvvaflilpqakkdffsshplrepvnate
dpssgyysttiryqatgfgtneteylfevdnltyvqlesrftpqfllqlnetiytsgkrs
nttgkliwkvnpeidttigewafwetkknltrkirseelsftvvxxxxxxxxsthhqdtg
eesassgklglitntiagvaglitggrrtrr

    Sequence, based on observed residues (ATOM records): (download) 
    >6hs4A (A:)
grsiplgvihnsalqvsdvdklvcrdklsstnqlrsvglnlegngvatdvpsatkrwgfr
sgvppkvvnyeagewaencynleikkpdgseclpaapdgirgfprcryvhkvsgtgpcag
dfafhkegafflydrlastviyrgttfaegvvaflilpqasgyysttiryqatgfgtnet
eylfevdnltyvqlesrftpqfllqlnetiytsgkrsnttgkliwkvnpeidttewafwe
tseelsftvvxxxxxxxx

  • Chain 'B':
    No sequence available.