PDB entry 6hrp

View 6hrp on RCSB PDB site
Description: CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH 6-(dimethylamino)-2-[2-(hydroxymethyl)-3-[1-methyl-5-[[5-(morpholine-4-carbonyl)-2-pyridyl]amino]-6-oxo-3-pyridyl]phenyl]-3,4-dihydroisoquinolin-1-one
Class: transferase
Keywords: transferase-transferase inhibitor complex, transferase
Deposited on 2018-09-28, released 2019-03-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-15, with a file datestamp of 2019-05-10.
Experiment type: XRAY
Resolution: 1.12 Å
R-factor: N/A
AEROSPACI score: 0.71 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase BTK
    Species: Homo sapiens [TaxId:9606]
    Gene: BTK, AGMX1, ATK, BPK
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06187
      • engineered mutation (112)
      • engineered mutation (115)
      • engineered mutation (247-248)
    Domains in SCOPe 2.08: d6hrpa_
  • Heterogens: GMQ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6hrpA (A:)
gsqqnknapstaglgygsweidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegs
msedefieeakvmmnlsheklvqlygvctkqrpifiiteymangcllnylrearhafqtq
qllemckdvceameyleskqflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvg
skfpvrwsppevlmyskfssksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrl
yrphlasaavytimyscwhekaderptfkillsnildvmdees

    Sequence, based on observed residues (ATOM records): (download) 
    >6hrpA (A:)
eidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefieeakvmmnlshe
klvqlygvctkqrpifiiteymangcllnylrearhafqtqqllemckdvceameylesk
qflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpvrwsppevlmyskfs
sksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphlasaavytimyscwh
ekaderptfkillsnildvmdee