PDB entry 6hrh

View 6hrh on RCSB PDB site
Description: structure of human erythroid-specific 5'-aminolevulinate synthase, alas2
Deposited on 2018-09-27, released 2018-11-07
The last revision was dated 2018-11-07, with a file datestamp of 2018-11-02.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 5-aminolevulinate synthase, erythroid-specific, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: ALAS2, ALASE, ASB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22557 (24-End)
      • expression tag (18-23)
      • conflict (102)
  • Chain 'B':
    Compound: 5-aminolevulinate synthase, erythroid-specific, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: ALAS2, ALASE, ASB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22557 (24-End)
      • expression tag (18-23)
      • conflict (102)
  • Heterogens: PLP, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6hrhA (A:)
mghhhhhhssgvdlgtenlyfqsmfsydqffrdkimekkqdhtyrvfktvnrwadaypfa
qhfseasvaskdvsvwcsndylgmsrhpqvlqatqetlqrhgvgaggtrnisgtskfhve
leqelaelhqkdsallfsscfvandstlftlakilpgceiysdagnhasmiqgirnsgaa
kfvfrhndpdhlkklleksnpkipkivafetvhsmdgaicpleelcdvshqygaltfvde
vhavglygsrgagigerdgimhkidiisgtlgkafgcvggyiastrdlvdmvrsyaagfi
fttslppmvlsgalesvrllkgeegqalrrahqrnvkhmrqllmdrglpvipcpshiipi
rvgnaalnsklcdlllskhgiyvqainyptvprgeellrlapsphhspqmmedfveklll
awtavglplqdvsvaacnfcrrpvhfelmsewersyfgnmgpqyvttya

    Sequence, based on observed residues (ATOM records):
    >6hrhA (A:)
lyfqsmfsydqffrdkimekkqdhtyrvfktvnrwadaypfaqhfskdvsvwcsndylgm
srhpqvlqatqetlqrhgvgaggtrnisgtskfhveleqelaelhqkdsallfsscfvan
dstlftlakilpgceiysdagnhasmiqgirnsgaakfvfrhndpdhlkklleksnpkip
kivafetvhsmdgaicpleelcdvshqygaltfvdevhavglygsrgagigerdgimhki
diisgtlgkafgcvggyiastrdlvdmvrsyaagfifttslppmvlsgalesvrllkgee
gqalrrahqrnvkhmrqllmdrglpvipcpshiipirvgnaalnsklcdlllskhgiyvq
ainyptvprgeellrlapsphhspqmmedfveklllawtavglplqnfcrrpvhfelmse
wersyfgnm

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6hrhB (B:)
mghhhhhhssgvdlgtenlyfqsmfsydqffrdkimekkqdhtyrvfktvnrwadaypfa
qhfseasvaskdvsvwcsndylgmsrhpqvlqatqetlqrhgvgaggtrnisgtskfhve
leqelaelhqkdsallfsscfvandstlftlakilpgceiysdagnhasmiqgirnsgaa
kfvfrhndpdhlkklleksnpkipkivafetvhsmdgaicpleelcdvshqygaltfvde
vhavglygsrgagigerdgimhkidiisgtlgkafgcvggyiastrdlvdmvrsyaagfi
fttslppmvlsgalesvrllkgeegqalrrahqrnvkhmrqllmdrglpvipcpshiipi
rvgnaalnsklcdlllskhgiyvqainyptvprgeellrlapsphhspqmmedfveklll
awtavglplqdvsvaacnfcrrpvhfelmsewersyfgnmgpqyvttya

    Sequence, based on observed residues (ATOM records):
    >6hrhB (B:)
lyfqsmfsydqffrdkimekkqdhtyrvfktvnrwadaypfaqhfsskdvsvwcsndylg
msrhpqvlqatqetlqrhgvgaggtrnisgtskfhveleqelaelhqkdsallfsscfva
ndstlftlakilpgceiysdagnhasmiqgirnsgaakfvfrhndpdhlkklleksnpki
pkivafetvhsmdgaicpleelcdvshqygaltfvdevhavglygsrgagigerdgimhk
idiisgtlgkafgcvggyiastrdlvdmvrsyaagfifttslppmvlsgalesvrllkge
egqalrrahqrnvkhmrqllmdrglpvipcpshiipirvgnaalnsklcdlllskhgiyv
qainyptvprgeellrlapsphhspqmmedfveklllawtavglplqcrrpvhfelmsew
ersyfgnm