PDB entry 6hr8

View 6hr8 on RCSB PDB site
Description: hmg-coa reductase from methanothermococcus thermolithotrophicus in complex with nadph at 2.9 a resolution
Deposited on 2018-09-26, released 2019-02-13
The last revision was dated 2019-03-20, with a file datestamp of 2019-03-15.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hmg-coa reductase
    Species: Methanothermococcus thermolithotrophicus DSM 2095 [TaxId:523845]
    Gene: HMGR
    Database cross-references and differences (RAF-indexed):
    • PDB 6HR8
  • Chain 'B':
    Compound: hmg-coa reductase
    Species: Methanothermococcus thermolithotrophicus DSM 2095 [TaxId:523845]
    Gene: HMGR
    Database cross-references and differences (RAF-indexed):
    • PDB 6HR8
  • Chain 'C':
    Compound: hmg-coa reductase
    Species: Methanothermococcus thermolithotrophicus DSM 2095 [TaxId:523845]
    Gene: HMGR
    Database cross-references and differences (RAF-indexed):
    • PDB 6HR8
  • Chain 'D':
    Compound: hmg-coa reductase
    Species: Methanothermococcus thermolithotrophicus DSM 2095 [TaxId:523845]
    Gene: HMGR
    Database cross-references and differences (RAF-indexed):
    • PDB 6HR8
  • Chain 'E':
    Compound: hmg-coa reductase
    Species: Methanothermococcus thermolithotrophicus DSM 2095 [TaxId:523845]
    Gene: HMGR
    Database cross-references and differences (RAF-indexed):
    • PDB 6HR8
  • Chain 'F':
    Compound: hmg-coa reductase
    Species: Methanothermococcus thermolithotrophicus DSM 2095 [TaxId:523845]
    Gene: HMGR
    Database cross-references and differences (RAF-indexed):
    • PDB 6HR8
  • Heterogens: NAP, SO4, PEG, NA

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6hr8A (A:)
mgsshhhhhhssglvprgshmmekgnneilekllkkeikpyqlddlvgekeaielrrkyi
ekisqvetkhighytidekeamkknienmigavqiplgfagplkingkyangefyvplat
tegalvasvnrgcsivtkcggvtvrviddkmtrapviktesvidavklkewikenfqrik
evaesttrhgklidinpilivgryvyprfvyktgdamgmnmvtiatekacnfieeelkke
ninihtvalsgnacvdkkpaginliegrgksiiaevflkeeeikkylkttskaieqvnmy
knligsaisnsmgfnahyaniigalflatgqdeahivegslgitvaectedgvyfsvtlp
dvpvgtvgggtrvetqkeclellgchggdkalkfaeivgatvlagelsligalsvghlar
ahaqlgr

    Sequence, based on observed residues (ATOM records):
    >6hr8A (A:)
nneilekllkkeikpyqlddlvgekeaielrrkyiekisqvetkhighytidekeamkkn
ienmigavqiplgfagplkingkyangefyvplattegalvasvnrgcsivtkcggvtvr
viddkmtrapviktesvidavklkewikenfqrikevaesttrhgklidinpilivgryv
yprfvyktgdamgmnmvtiatekacnfieeelkkeninihtvalsgnacvdkkpaginli
egrgksiiaevflkeeeikkylkttskaieqvnmyknligsaisnsmgfnahyaniigal
flatgqdeahivegslgitvaectedgvyfsvtlpdvpvgtvgggtrvetqkeclellgc
hggdkalkfaeivgatvlagelsligalsvghlarah

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6hr8B (B:)
mgsshhhhhhssglvprgshmmekgnneilekllkkeikpyqlddlvgekeaielrrkyi
ekisqvetkhighytidekeamkknienmigavqiplgfagplkingkyangefyvplat
tegalvasvnrgcsivtkcggvtvrviddkmtrapviktesvidavklkewikenfqrik
evaesttrhgklidinpilivgryvyprfvyktgdamgmnmvtiatekacnfieeelkke
ninihtvalsgnacvdkkpaginliegrgksiiaevflkeeeikkylkttskaieqvnmy
knligsaisnsmgfnahyaniigalflatgqdeahivegslgitvaectedgvyfsvtlp
dvpvgtvgggtrvetqkeclellgchggdkalkfaeivgatvlagelsligalsvghlar
ahaqlgr

    Sequence, based on observed residues (ATOM records):
    >6hr8B (B:)
nneilekllkkeikpyqlddlvgekeaielrrkyiekisqvetkhighytidekeamkkn
ienmigavqiplgfagplkingkyangefyvplattegalvasvnrgcsivtkcggvtvr
viddkmtrapviktesvidavklkewikenfqrikevaesttrhgklidinpilivgryv
yprfvyktgdamgmnmvtiatekacnfieeelkkeninihtvalsgnacvdkkpaginli
egrgksiiaevflkeeeikkylkttskaieqvnmyknligsaisnsmgfnahyaniigal
flatgqdeahivegslgitvaectedgvyfsvtlpdvpvgtvgggtrvetqkeclellgc
hggdkalkfaeivgatvlagelsligalsvghlara

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6hr8C (C:)
mgsshhhhhhssglvprgshmmekgnneilekllkkeikpyqlddlvgekeaielrrkyi
ekisqvetkhighytidekeamkknienmigavqiplgfagplkingkyangefyvplat
tegalvasvnrgcsivtkcggvtvrviddkmtrapviktesvidavklkewikenfqrik
evaesttrhgklidinpilivgryvyprfvyktgdamgmnmvtiatekacnfieeelkke
ninihtvalsgnacvdkkpaginliegrgksiiaevflkeeeikkylkttskaieqvnmy
knligsaisnsmgfnahyaniigalflatgqdeahivegslgitvaectedgvyfsvtlp
dvpvgtvgggtrvetqkeclellgchggdkalkfaeivgatvlagelsligalsvghlar
ahaqlgr

    Sequence, based on observed residues (ATOM records):
    >6hr8C (C:)
neilekllkkeikpyqlddlvgekeaielrrkyiekisqvetkhighytidekeamkkni
enmigavqiplgfagplkingkyangefyvplattegalvasvnrgcsivtkcggvtvrv
iddkmtrapviktesvidavklkewikenfqrikevaesttrhgklidinpilivgryvy
prfvyktgdamgmnmvtiatekacnfieeelkkeninihtvalsgnacvdkkpaginlie
grgksiiaevflkeeeikkylkttskaieqvnmyknligsaisnsmgfnahyaniigalf
latgqdeahivegslgitvaectedgvyfsvtlpdvpvgtvgggtrvetqkeclellgch
ggdkalkfaeivgatvlagelsligalsvghlarah

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6hr8D (D:)
mgsshhhhhhssglvprgshmmekgnneilekllkkeikpyqlddlvgekeaielrrkyi
ekisqvetkhighytidekeamkknienmigavqiplgfagplkingkyangefyvplat
tegalvasvnrgcsivtkcggvtvrviddkmtrapviktesvidavklkewikenfqrik
evaesttrhgklidinpilivgryvyprfvyktgdamgmnmvtiatekacnfieeelkke
ninihtvalsgnacvdkkpaginliegrgksiiaevflkeeeikkylkttskaieqvnmy
knligsaisnsmgfnahyaniigalflatgqdeahivegslgitvaectedgvyfsvtlp
dvpvgtvgggtrvetqkeclellgchggdkalkfaeivgatvlagelsligalsvghlar
ahaqlgr

    Sequence, based on observed residues (ATOM records):
    >6hr8D (D:)
neilekllkkeikpyqlddlvgekeaielrrkyiekisqvetkhighytidekeamkkni
enmigavqiplgfagplkingkyangefyvplattegalvasvnrgcsivtkcggvtvrv
iddkmtrapviktesvidavklkewikenfqrikevaesttrhgklidinpilivgryvy
prfvyktgdamgmnmvtiatekacnfieeelkkeninihtvalsgnacvdkkpaginlie
grgksiiaevflkeeeikkylkttskaieqvnmyknligsaisnsmgfnahyaniigalf
latgqdeahivegslgitvaectedgvyfsvtlpdvpvgtvgggtrvetqkeclellgch
ggdkalkfaeivgatvlagelsligalsvghlarah

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6hr8E (E:)
mgsshhhhhhssglvprgshmmekgnneilekllkkeikpyqlddlvgekeaielrrkyi
ekisqvetkhighytidekeamkknienmigavqiplgfagplkingkyangefyvplat
tegalvasvnrgcsivtkcggvtvrviddkmtrapviktesvidavklkewikenfqrik
evaesttrhgklidinpilivgryvyprfvyktgdamgmnmvtiatekacnfieeelkke
ninihtvalsgnacvdkkpaginliegrgksiiaevflkeeeikkylkttskaieqvnmy
knligsaisnsmgfnahyaniigalflatgqdeahivegslgitvaectedgvyfsvtlp
dvpvgtvgggtrvetqkeclellgchggdkalkfaeivgatvlagelsligalsvghlar
ahaqlgr

    Sequence, based on observed residues (ATOM records):
    >6hr8E (E:)
neilekllkkeikpyqlddlvgekeaielrrkyiekisqvetkhighytidekeamkkni
enmigavqiplgfagplkingkyangefyvplattegalvasvnrgcsivtkcggvtvrv
iddkmtrapviktesvidavklkewikenfqrikevaesttrhgklidinpilivgryvy
prfvyktgdamgmnmvtiatekacnfieeelkkeninihtvalsgnacvdkkpaginlie
grgksiiaevflkeeeikkylkttskaieqvnmyknligsaisnsmgfnahyaniigalf
latgqdeahivegslgitvaectedgvyfsvtlpdvpvgtvgggtrvetqkeclellgch
ggdkalkfaeivgatvlagelsligalsvghlarah

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6hr8F (F:)
mgsshhhhhhssglvprgshmmekgnneilekllkkeikpyqlddlvgekeaielrrkyi
ekisqvetkhighytidekeamkknienmigavqiplgfagplkingkyangefyvplat
tegalvasvnrgcsivtkcggvtvrviddkmtrapviktesvidavklkewikenfqrik
evaesttrhgklidinpilivgryvyprfvyktgdamgmnmvtiatekacnfieeelkke
ninihtvalsgnacvdkkpaginliegrgksiiaevflkeeeikkylkttskaieqvnmy
knligsaisnsmgfnahyaniigalflatgqdeahivegslgitvaectedgvyfsvtlp
dvpvgtvgggtrvetqkeclellgchggdkalkfaeivgatvlagelsligalsvghlar
ahaqlgr

    Sequence, based on observed residues (ATOM records):
    >6hr8F (F:)
neilekllkkeikpyqlddlvgekeaielrrkyiekisqvetkhighytidekeamkkni
enmigavqiplgfagplkingkyangefyvplattegalvasvnrgcsivtkcggvtvrv
iddkmtrapviktesvidavklkewikenfqrikevaesttrhgklidinpilivgryvy
prfvyktgdamgmnmvtiatekacnfieeelkkeninihtvalsgnacvdkkpaginlie
grgksiiaevflkeeeikkylkttskaieqvnmyknligsaisnsmgfnahyaniigalf
latgqdeahivegslgitvaectedgvyfsvtlpdvpvgtvgggtrvetqkeclellgch
ggdkalkfaeivgatvlagelsligalsvghlarah