PDB entry 6hr2
View 6hr2 on RCSB PDB site
Description: Crystal structure of PROTAC 2 in complex with the bromodomain of human SMARCA4 and pVHL:ElonginC:ElonginB
Class: transcription
Keywords: bromodomain, BRG1, SMARCA4, PROTAC, VHL, ternary complex, transcription
Deposited on
2018-09-26, released
2019-06-12
The last revision prior to the SCOPe 2.08 freeze date was dated
2019-07-03, with a file datestamp of
2019-06-28.
Experiment type: XRAY
Resolution: 1.76 Å
R-factor: N/A
AEROSPACI score: 0.38
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Transcription activator BRG1
Species: Homo sapiens [TaxId:9606]
Gene: SMARCA4, BAF190A, BRG1, SNF2B, SNF2L4
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6hr2a_ - Chain 'B':
Compound: von hippel-lindau disease tumor suppressor
Species: Homo sapiens [TaxId:9606]
Gene: VHL
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6hr2b_ - Chain 'C':
Compound: Elongin-C
Species: Homo sapiens [TaxId:9606]
Gene: ELOC, TCEB1
Database cross-references and differences (RAF-indexed):
- Uniprot Q15369 (1-96)
- initiating methionine (0)
Domains in SCOPe 2.08: d6hr2c1, d6hr2c2 - Chain 'D':
Compound: Elongin-B
Species: Homo sapiens [TaxId:9606]
Gene: ELOB, TCEB2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6hr2d_ - Chain 'E':
Compound: Transcription activator BRG1
Species: Homo sapiens [TaxId:9606]
Gene: SMARCA4, BAF190A, BRG1, SNF2B, SNF2L4
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6hr2e_ - Chain 'F':
Compound: von hippel-lindau disease tumor suppressor
Species: Homo sapiens [TaxId:9606]
Gene: VHL
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6hr2f_ - Chain 'G':
Compound: Elongin-C
Species: Homo sapiens [TaxId:9606]
Gene: ELOC, TCEB1
Database cross-references and differences (RAF-indexed):
- Uniprot Q15369 (1-96)
- initiating methionine (0)
Domains in SCOPe 2.08: d6hr2g1, d6hr2g2 - Chain 'H':
Compound: Elongin-B
Species: Homo sapiens [TaxId:9606]
Gene: ELOB, TCEB2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6hr2h_ - Heterogens: FWZ, DMS, EDO, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>6hr2A (A:)
eklspnppnltkkmkkivdavikykdsssgrqlsevfiqlpsrkelpeyyelirkpvdfk
kikerirnhkyrslndlekdvmllcqnaqtfnlegsliyedsivlqsvftsvrqkieked
Sequence, based on observed residues (ATOM records): (download)
>6hr2A (A:)
spnppnltkkmkkivdavikykdsssgrqlsevfiqlpsrkelpeyyelirkpvdfkkik
erirnhkyrslndlekdvmllcqnaqtfnlegsliyedsivlqsvftsvrqkieked
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>6hr2B (B:)
pvlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihsyrghlwlfr
dagthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvkpenyrrldi
vrslyedledhpnvqkdlerltqeriahq
- Chain 'C':
Sequence, based on SEQRES records: (download)
>6hr2C (C:)
mmyvklissdghefivkrehaltsgtikamlsgpgqfaenetnevnfreipshvlskvcm
yftykvrytnssteipefpiapeialellmaanfldc
Sequence, based on observed residues (ATOM records): (download)
>6hr2C (C:)
mmyvklissdghefivkrehaltsgtikamlsnevnfreipshvlskvcmyftykvrytn
ssteipefpiapeialellmaanfldc
- Chain 'D':
Sequence; same for both SEQRES and ATOM records: (download)
>6hr2D (D:)
mdvflmirrhkttiftdakesstvfelkrivegilkrppdeqrlykddqllddgktlgec
gftsqtarpqapatvglafraddtfealciepfssppelpdvmk
- Chain 'E':
Sequence; same for both SEQRES and ATOM records: (download)
>6hr2E (E:)
eklspnppnltkkmkkivdavikykdsssgrqlsevfiqlpsrkelpeyyelirkpvdfk
kikerirnhkyrslndlekdvmllcqnaqtfnlegsliyedsivlqsvftsvrqkieked
- Chain 'F':
Sequence; same for both SEQRES and ATOM records: (download)
>6hr2F (F:)
pvlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihsyrghlwlfr
dagthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvkpenyrrldi
vrslyedledhpnvqkdlerltqeriahq
- Chain 'G':
Sequence, based on SEQRES records: (download)
>6hr2G (G:)
mmyvklissdghefivkrehaltsgtikamlsgpgqfaenetnevnfreipshvlskvcm
yftykvrytnssteipefpiapeialellmaanfldc
Sequence, based on observed residues (ATOM records): (download)
>6hr2G (G:)
mmyvklissdghefivkrehaltsgtikamlsnevnfreipshvlskvcmyftykvrytn
ssteipefpiapeialellmaanfldc
- Chain 'H':
Sequence, based on SEQRES records: (download)
>6hr2H (H:)
mdvflmirrhkttiftdakesstvfelkrivegilkrppdeqrlykddqllddgktlgec
gftsqtarpqapatvglafraddtfealciepfssppelpdvmk
Sequence, based on observed residues (ATOM records): (download)
>6hr2H (H:)
mdvflmirrhkttiftdakesstvfelkrivegilkrppdeqrlykddqllddgktlgec
gftsqtarpqapatvglafraddtfealciepfssppelpdvm