PDB entry 6hqy

View 6hqy on RCSB PDB site
Description: crystal structure of schistosoma mansoni hdac8 complexed with pci- 34051
Deposited on 2018-09-25, released 2018-10-31
The last revision was dated 2018-11-28, with a file datestamp of 2018-11-23.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone deacetylase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: HDAC8
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Histone deacetylase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: HDAC8
    Database cross-references and differences (RAF-indexed):
    • Uniprot A5H660 (Start-440)
      • expression tag (441-446)
  • Chain 'C':
    Compound: Histone deacetylase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: HDAC8
    Database cross-references and differences (RAF-indexed):
    • Uniprot A5H660 (Start-440)
      • expression tag (441-446)
  • Chain 'D':
    Compound: Histone deacetylase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: HDAC8
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ZN, K, GKW, GOL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6hqyA (A:)
    hmsvgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeav
    tafhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgsl
    aaasalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstppetspnrqtr
    vlyvdldlhhgdgveeafwysprvvtfsvhhaspgffpgtgtwnmvdndklpiflngagr
    grfsafnlpleegindldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltn
    fypnlnldsdcdsecslsgylyaikkilswkvptlilggggynfpdtarlwtrvtaltie
    evkgkkmtispeipehsyfsrygpdfeldidyfpheshnktldsiqkhhrrileqlrnya
    dlnkliydydqvyqlynltgmgslvpr
    

    Sequence, based on observed residues (ATOM records):
    >6hqyA (A:)
    svgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeavta
    fhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgslaa
    asalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvssqtrvlyvdldlhhg
    dgveeafwysprvvtfsvhhaspgffpgtgtwnmiflngagrgrfsafnlpleegindld
    wsnaigpildslniviqpsyvvvqcgadclatdphrifrltnfyplsgylyaikkilswk
    vptlilggggynfpdtarlwtrvtaltieevkgkkmtispeipehsyfsrygpdfeldid
    yfpdsiqkhhrrileqlrnyadlnkliydydqvyqly
    

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6hqyB (B:)
    hmsvgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeav
    tafhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgsl
    aaasalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstppetspnrqtr
    vlyvdldlhhgdgveeafwysprvvtfsvhhaspgffpgtgtwnmvdndklpiflngagr
    grfsafnlpleegindldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltn
    fypnlnldsdcdsecslsgylyaikkilswkvptlilggggynfpdtarlwtrvtaltie
    evkgkkmtispeipehsyfsrygpdfeldidyfpheshnktldsiqkhhrrileqlrnya
    dlnkliydydqvyqlynltgmgslvpr
    

    Sequence, based on observed residues (ATOM records):
    >6hqyB (B:)
    svgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeavta
    fhsteyvdalkklqmlhceltaddellmdsfslnydcpgfpsvfdyslaavqgslaaasa
    licrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstqtrvlyvdldlhhgdg
    veeafwysprvvtfsvhhaspgffpgtgtwnlpiflngagrgrfsafnlpleegindldw
    snaigpildslniviqpsyvvvqcgadclatdphrifrltnfyplsgylyaikkilswkv
    ptlilggggynfpdtarlwtrvtaltieevkgkkmtispeipehsyfsrygpdfeldidy
    fphedsiqkhhrrileqlrnyadlnkliydydqvyqlynltgmgslvpr
    

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6hqyC (C:)
    hmsvgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeav
    tafhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgsl
    aaasalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstppetspnrqtr
    vlyvdldlhhgdgveeafwysprvvtfsvhhaspgffpgtgtwnmvdndklpiflngagr
    grfsafnlpleegindldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltn
    fypnlnldsdcdsecslsgylyaikkilswkvptlilggggynfpdtarlwtrvtaltie
    evkgkkmtispeipehsyfsrygpdfeldidyfpheshnktldsiqkhhrrileqlrnya
    dlnkliydydqvyqlynltgmgslvpr
    

    Sequence, based on observed residues (ATOM records):
    >6hqyC (C:)
    svgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeavta
    fhsteyvdalkklqmlhceeltaddellmdsfslnydcpgfpsvfdyslaavqgslaaas
    alicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstqtrvlyvdldlhhgd
    gveeafwysprvvtfsvhhaspgffpgtgtwnmpiflngagrgrfsafnlpleegindld
    wsnaigpildslniviqpsyvvvqcgadclatdphrifrltnfyplsgylyaikkilswk
    vptlilggggynfpdtarlwtrvtaltieevkgkkmtispeipehsyfsrygpdfeldid
    yfphtldsiqkhhrrileqlrnyadlnkliydydqvyqlynltgmgslvpr
    

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6hqyD (D:)
    hmsvgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeav
    tafhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgsl
    aaasalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstppetspnrqtr
    vlyvdldlhhgdgveeafwysprvvtfsvhhaspgffpgtgtwnmvdndklpiflngagr
    grfsafnlpleegindldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltn
    fypnlnldsdcdsecslsgylyaikkilswkvptlilggggynfpdtarlwtrvtaltie
    evkgkkmtispeipehsyfsrygpdfeldidyfpheshnktldsiqkhhrrileqlrnya
    dlnkliydydqvyqlynltgmgslvpr
    

    Sequence, based on observed residues (ATOM records):
    >6hqyD (D:)
    svgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeavta
    fhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgslaa
    asalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstrvlyvdldlhhgd
    gveeafwysprvvtfsvhhaspgffpgtgtwniflngagrgrfsafnlpleegindldws
    naigpildslniviqpsyvvvqcgadclatdphrifrltnfyplsgylyaikkilswkvp
    tlilggggynfpdtarlwtrvtaltieevkgkkmtispeipehsyfsrygpdfeldidyf
    pdsiqkhhrrileqlrnyadlnkliydydqvyqly