PDB entry 6hpr

View 6hpr on RCSB PDB site
Description: Crystal structure of cIAP1 RING domain bound to UbcH5B-Ub and a non-covalent Ub
Class: ligase
Keywords: Ubiquitin, E3, cIAP1, UbcH5B, ubiquitin ligase, LIGASE
Deposited on 2018-09-21, released 2018-12-12
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-12-12, with a file datestamp of 2018-12-07.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Baculoviral IAP repeat-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC2, API1, MIHB, RNF48
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Polyubiquitin-B
    Species: Homo sapiens [TaxId:9606]
    Gene: UBB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0CG47 (2-End)
      • insertion (4)
    Domains in SCOPe 2.07: d6hprb_
  • Chain 'C':
    Compound: ubiquitin-conjugating enzyme e2 d2
    Species: Homo sapiens [TaxId:9606]
    Gene: UBE2D2, PUBC1, UBC4, UBC5B, UBCH4, UBCH5B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62837 (Start-146)
      • conflict (84)
    Domains in SCOPe 2.07: d6hprc_
  • Chain 'D':
    Compound: Polyubiquitin-B
    Species: Homo sapiens [TaxId:9606]
    Gene: UBB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0CG47 (Start-80)
      • insertion (4)
    Domains in SCOPe 2.07: d6hprd_
  • Heterogens: ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6hprB (B:)
    gsggsmqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrt
    lsdyniqkestlhlvlrlrgg
    

    Sequence, based on observed residues (ATOM records): (download)
    >6hprB (B:)
    ggsmqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtls
    dyniqkestlhlvlrlr
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >6hprC (C:)
    malkrihkelndlardppaqcsagpvgddmfhwqatimgpndspyqggvffltihfptdy
    pfkppkvafttriyhpninsngsikldilrsqwspaltiskvllsicsllcdpnpddplv
    peiariyktdrekynriarewtqkyam
    

    Sequence, based on observed residues (ATOM records): (download)
    >6hprC (C:)
    alkrihkelndlardppaqcsagpvgddmfhwqatimgpndspyqggvffltihfptdyp
    fkppkvafttriyhpninsngsikldilrsqwspaltiskvllsicsllcdpnpddplvp
    eiariyktdrekynriarewtqkyam
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >6hprD (D:)
    gsggsmqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrt
    lsdyniqkestlhlvlrlrgg
    

    Sequence, based on observed residues (ATOM records): (download)
    >6hprD (D:)
    gsmqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsd
    yniqkestlhlvlrlrgg