PDB entry 6hn8

View 6hn8 on RCSB PDB site
Description: Structure of BM3 heme domain in complex with troglitazone
Class: oxidoreductase
Keywords: cytochrome P450, monooxygenase, heme binding, antidiabetic, troglitazone, OXIDOREDUCTASE
Deposited on 2018-09-14, released 2019-10-09
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-10-09, with a file datestamp of 2019-10-04.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bifunctional cytochrome P450/NADPH--P450 reductase
    Species: Bacillus megaterium [TaxId:1404]
    Gene: BTA37_15100
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A1Q8UP87 (Start-456)
      • engineered mutation (83)
      • engineered mutation (88)
    Domains in SCOPe 2.07: d6hn8a_
  • Chain 'B':
    Compound: Bifunctional cytochrome P450/NADPH--P450 reductase
    Species: Bacillus megaterium [TaxId:1404]
    Gene: BTA37_15100
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A1Q8UP87 (Start-456)
      • engineered mutation (83)
      • engineered mutation (88)
    Domains in SCOPe 2.07: d6hn8b_
  • Heterogens: TDZ, HEM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6hn8A (A:)
bmtikempqpktfgelknlpllntdkpvqalmkiadelgeifkfeapgrvtrylssqrli
keacdesrfdknlsqalkfvrdffgdglvtswtheknwkkahnillpsfsqqamkgyham
mvdiavqlvqkwerlnadehievpedmtrltldtiglcgfnyrfnsfyrdqphpfitsmv
raldeamnklqranpddpaydenkrqfqedikvmndlvdkiiadrkasgeqsddllthml
ngkdpetgeplddeniryqiitfliaghettsgllsfalyflvknphvlqkaaeeaarvl
vdpvpsykqvkqlkyvgmvlnealrlwptapafslyakedtvlggeyplekgdelmvlip
qlhrdktiwgddveefrperfenpsaipqhafkpfgngqracigqqfalheatlvlgmml
khfdfedhtnyeldiketltlkpegfvvkakskkipl

    Sequence, based on observed residues (ATOM records): (download) 
    >6hn8A (A:)
kempqpktfgelknlpllntdkpvqalmkiadelgeifkfeapgrvtrylssqrlikeac
desrfdknlsqalkfvrdffgdglvtswtheknwkkahnillpsfsqqamkgyhammvdi
avqlvqkwerlnadehievpedmtrltldtiglcgfnyrfnsfyrdqphpfitsmvrald
eamnklqranpddpaydenkrqfqedikvmndlvdkiiadrkasgeqsddllthmlngkd
petgeplddeniryqiitfliaghettsgllsfalyflvknphvlqkaaeeaarvlvdpv
psykqvkqlkyvgmvlnealrlwptapafslyakedtvlggeyplekgdelmvlipqlhr
dktiwgddveefrperfenpsaipqhafkpfgngqracigqqfalheatlvlgmmlkhfd
fedhtnyeldiketltlkpegfvvkakskkipl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6hn8B (B:)
bmtikempqpktfgelknlpllntdkpvqalmkiadelgeifkfeapgrvtrylssqrli
keacdesrfdknlsqalkfvrdffgdglvtswtheknwkkahnillpsfsqqamkgyham
mvdiavqlvqkwerlnadehievpedmtrltldtiglcgfnyrfnsfyrdqphpfitsmv
raldeamnklqranpddpaydenkrqfqedikvmndlvdkiiadrkasgeqsddllthml
ngkdpetgeplddeniryqiitfliaghettsgllsfalyflvknphvlqkaaeeaarvl
vdpvpsykqvkqlkyvgmvlnealrlwptapafslyakedtvlggeyplekgdelmvlip
qlhrdktiwgddveefrperfenpsaipqhafkpfgngqracigqqfalheatlvlgmml
khfdfedhtnyeldiketltlkpegfvvkakskkipl

    Sequence, based on observed residues (ATOM records): (download) 
    >6hn8B (B:)
ikempqpktfgelknlpllntdkpvqalmkiadelgeifkfeapgrvtrylssqrlikea
cdesrfdknlsqalkfvrdffgdglvtswtheknwkkahnillpsfsqqamkgyhammvd
iavqlvqkwerlnadehievpedmtrltldtiglcgfnyrfnsfyrdqphpfitsmvral
deamnklqranpddpaydenkrqfqedikvmndlvdkiiadrkasqsddllthmlngkdp
etgeplddeniryqiitfliaghettsgllsfalyflvknphvlqkaaeeaarvlvdpvp
sykqvkqlkyvgmvlnealrlwptapafslyakedtvlggeyplekgdelmvlipqlhrd
ktiwgddveefrperfenpsaipqhafkpfgngqracigqqfalheatlvlgmmlkhfdf
edhtnyeldiketltlkpegfvvkakskkipl