PDB entry 6hlo

View 6hlo on RCSB PDB site
Description: crystal structure of the neurokinin 1 receptor in complex with the small molecule antagonist aprepitant
Deposited on 2018-09-11, released 2019-01-16
The last revision was dated 2019-01-16, with a file datestamp of 2019-01-11.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Substance-P receptor,GlgA glycogen synthase,Substance-P receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: TACR1, NK1R, TAC1R
    Database cross-references and differences (RAF-indexed):
    • Uniprot P25103 (Start-227)
      • engineered mutation (73)
      • engineered mutation (115)
      • engineered mutation (143)
      • engineered mutation (180)
      • engineered mutation (214)
      • engineered mutation (223)
      • conflict (226)
    • Uniprot Q9V2J8 (228-421)
    • Uniprot P25103 (422-End)
      • engineered mutation (427)
  • Heterogens: GBQ, CIT, OLA, OLC, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6hloA (A:)
mdnvlpvdsdlspnistntsepnqfvqpawqivlwaaaytvivvtsvvgnvvvmwiilah
krmrtvtnyflvnaafaeasmaafntvvnftyavhnewyyglfyckfhnffpiaaifasi
ysmtavafdrymaiihplqprlsltatkvvicviwvlalllafpqgyysttetmpsrvvc
kiewpehpnkiyekvyhicvtvliyflpllvigylytvvgitlrasgidcsfwnesyltg
srderkksllskfgmdegvtfmfigrfdrgqkgvdvllkaieilsskkefqemrfiiigk
gdpelegwarsleekhgnvkvitemlsrefvrelygsvdfviipsyfepfglvaleamcl
gaipiasavgglrdiitnetgilvkagdpgelanailkalelsrsdlskfrenckkrams
fseqvsaarkvvkmmivvvctfaicwlpfhiffllpyinpdlylkkfiqqvylaimwlam
sstmynpiiycclndrfrlgfkhafrccpfisagdyegle

    Sequence, based on observed residues (ATOM records):
    >6hloA (A:)
pawqivlwaaaytvivvtsvvgnvvvmwiilahkrmrtvtnyflvnaafaeasmaafntv
vnftyavhnewyyglfyckfhnffpiaaifasiysmtavafdrymaiihplqprlsltat
kvvicviwvlalllafpqgyysttetmpsrvvckiewpehpnkiyekvyhicvtvliyfl
pllvigylytvvgitlrasgidcsfwnesyltgsrderkksllskfgmdegvtfmfigrf
drgqkgvdvllkaieilsskkefqemrfiiigkgdpelegwarsleekhgnvkvitemls
refvrelygsvdfviipsyfepfglvaleamclgaipiasavgglrdiitnetgilvkag
dpgelanailkalelsrsdlskfrenckkramsfseqvsaarkvvkmmivvvctfaicwl
pfhiffllpyinpdlyfiqqvylaimwlamsstmynpiiycclndrfrlgfkhafrccp