PDB entry 6hkq

View 6hkq on RCSB PDB site
Description: Human GPX4 in complex with covalent Inhibitor ML162 (S enantiomer)
Class: oxidoreductase
Keywords: ANTI-OXIDATVE DEFENSE SYSTEM, Covalent inhibitor, OXIDOREDUCTASE
Deposited on 2018-09-07, released 2020-04-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-16, with a file datestamp of 2021-06-11.
Experiment type: XRAY
Resolution: 1.54 Å
R-factor: N/A
AEROSPACI score: 0.55 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Phospholipid hydroperoxide glutathione peroxidase
    Species: Homo sapiens [TaxId:9606]
    Gene: GPX4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P36969 (Start-169)
      • engineered mutation (65)
      • expression tag (170)
    Domains in SCOPe 2.08: d6hkqa1, d6hkqa2
  • Heterogens: G9N, SO4, EDO, DMS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6hkqA (A:)
mcasrddwrcarsmhefsakdidghmvnldkyrgfvcivtnvasqagktevnytqlvdlh
aryaesglrilafpcnqfgkqepgsneeikefaagynvkfdmfskicvngddahplwkwm
kiqpkgkgilgnaikwnftkflidkngcvvkrygpmeeplviekdlphyfhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6hkqA (A:)
ddwrcarsmhefsakdidghmvnldkyrgfvcivtnvasqagktevnytqlvdlharyae
sglrilafpcnqfgkqepgsneeikefaagynvkfdmfskicvngddahplwkwmkiqpk
gkgilgnaikwnftkflidkngcvvkrygpmeeplviekdlphyfh