PDB entry 6hk6

View 6hk6 on RCSB PDB site
Description: human riok2 bound to inhibitor
Deposited on 2018-09-05, released 2018-10-24
The last revision was dated 2019-10-02, with a file datestamp of 2019-09-27.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase RIO2
    Species: Homo sapiens [TaxId:9606]
    Gene: RIOK2, RIO2
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Serine/threonine-protein kinase RIO2
    Species: Homo sapiens [TaxId:9606]
    Gene: RIOK2, RIO2
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Serine/threonine-protein kinase RIO2
    Species: Homo sapiens [TaxId:9606]
    Gene: RIOK2, RIO2
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Serine/threonine-protein kinase RIO2
    Species: Homo sapiens [TaxId:9606]
    Gene: RIOK2, RIO2
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Serine/threonine-protein kinase RIO2
    Species: Homo sapiens [TaxId:9606]
    Gene: RIOK2, RIO2
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Serine/threonine-protein kinase RIO2
    Species: Homo sapiens [TaxId:9606]
    Gene: RIOK2, RIO2
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Serine/threonine-protein kinase RIO2
    Species: Homo sapiens [TaxId:9606]
    Gene: RIOK2, RIO2
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Serine/threonine-protein kinase RIO2
    Species: Homo sapiens [TaxId:9606]
    Gene: RIOK2, RIO2
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: Serine/threonine-protein kinase RIO2
    Species: Homo sapiens [TaxId:9606]
    Gene: RIOK2, RIO2
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: Serine/threonine-protein kinase RIO2
    Species: Homo sapiens [TaxId:9606]
    Gene: RIOK2, RIO2
    Database cross-references and differences (RAF-indexed):
  • Heterogens: G8H, CL, EDO, EPE, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6hk6A (A:)
smgkvnvaklrymsrddfrvltavemgmknheivpgsliasiaslkhggcnkvlrelvkh
kliawertktvqgyrltnagydylalktlssrqvvesvgnqmgvgkesdiyivaneegqq
falklhrlgrtsfrnlknkrdyhkyrhnvswlylsrlsamkefaymkalyerkfpvpkpi
dynrhavvmelingyplcqihhvedpasvydeamelivklanhglihgdfnefnlildes
dhitmidfpqmvstshpnaewyfdrdvkcikdffmkrfsyeselfptfkdirredtldve
vsasgytkemqaddellhplgpddknietk

    Sequence, based on observed residues (ATOM records):
    >6hk6A (A:)
gkvnvaklrymsrddfrvltavemgmknheivpgsliasiaslkhggcnkvlrelvkhkl
iawertktvqgyrltnagydylalktlssrqvvesvgnqmgvgkesdiyivaneegqqfa
lklhrlgrtsfrnlhnvswlylsrlsamkefaymkalyerkfpvpkpidynrhavvmeli
ngyplcqihhvedpasvydeamelivklanhglihgdfnefnlildesdhitmidfpqmv
stshpnaewyfdrdvkcikdffmkrfsyeselfptfkdirredtldvevs

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6hk6B (B:)
smgkvnvaklrymsrddfrvltavemgmknheivpgsliasiaslkhggcnkvlrelvkh
kliawertktvqgyrltnagydylalktlssrqvvesvgnqmgvgkesdiyivaneegqq
falklhrlgrtsfrnlknkrdyhkyrhnvswlylsrlsamkefaymkalyerkfpvpkpi
dynrhavvmelingyplcqihhvedpasvydeamelivklanhglihgdfnefnlildes
dhitmidfpqmvstshpnaewyfdrdvkcikdffmkrfsyeselfptfkdirredtldve
vsasgytkemqaddellhplgpddknietk

    Sequence, based on observed residues (ATOM records):
    >6hk6B (B:)
gkvnvaklrymsrddfrvltavemgmknheivpgsliasiaslkhggcnkvlrelvkhkl
iawertktvqgyrltnagydylalktlssrqvvesvgnqmgvgkesdiyivaneegqqfa
lklhrlgrtsfrnlhnvswlylsrlsamkefaymkalyerkfpvpkpidynrhavvmeli
ngyplcqihhvedpasvydeamelivklanhglihgdfnefnlildesdhitmidfpqmv
stshpnaewyfdrdvkcikdffmkrfsyeselfptfkdirredtldvevs

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6hk6C (C:)
smgkvnvaklrymsrddfrvltavemgmknheivpgsliasiaslkhggcnkvlrelvkh
kliawertktvqgyrltnagydylalktlssrqvvesvgnqmgvgkesdiyivaneegqq
falklhrlgrtsfrnlknkrdyhkyrhnvswlylsrlsamkefaymkalyerkfpvpkpi
dynrhavvmelingyplcqihhvedpasvydeamelivklanhglihgdfnefnlildes
dhitmidfpqmvstshpnaewyfdrdvkcikdffmkrfsyeselfptfkdirredtldve
vsasgytkemqaddellhplgpddknietk

    Sequence, based on observed residues (ATOM records):
    >6hk6C (C:)
gkvnvaklrymsrddfrvltavemgmknheivpgsliasiaslkhggcnkvlrelvkhkl
iawertktvqgyrltnagydylalktlssrqvvesvgnqmgvgkesdiyivaneegqqfa
lklhrlgrtsfrnlhnvswlylsrlsamkefaymkalyerkfpvpkpidynrhavvmeli
ngyplcqihhvedpasvydeamelivklanhglihgdfnefnlildesdhitmidfpqmv
stshpnaewyfdrdvkcikdffmkrfsyeselfptfkdirredtldvevs

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6hk6D (D:)
smgkvnvaklrymsrddfrvltavemgmknheivpgsliasiaslkhggcnkvlrelvkh
kliawertktvqgyrltnagydylalktlssrqvvesvgnqmgvgkesdiyivaneegqq
falklhrlgrtsfrnlknkrdyhkyrhnvswlylsrlsamkefaymkalyerkfpvpkpi
dynrhavvmelingyplcqihhvedpasvydeamelivklanhglihgdfnefnlildes
dhitmidfpqmvstshpnaewyfdrdvkcikdffmkrfsyeselfptfkdirredtldve
vsasgytkemqaddellhplgpddknietk

    Sequence, based on observed residues (ATOM records):
    >6hk6D (D:)
gkvnvaklrymsrddfrvltavemgmknheivpgsliasiaslkhggcnkvlrelvkhkl
iawertktvqgyrltnagydylalktlssrqvvesvgnqmgvgkesdiyivaneegqqfa
lklhrlgrtsfrnlhnvswlylsrlsamkefaymkalyerkfpvpkpidynrhavvmeli
ngyplcqihhvedpasvydeamelivklanhglihgdfnefnlildesdhitmidfpqmv
stshpnaewyfdrdvkcikdffmkrfsyeselfptfkdirredtldvevs

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6hk6E (E:)
smgkvnvaklrymsrddfrvltavemgmknheivpgsliasiaslkhggcnkvlrelvkh
kliawertktvqgyrltnagydylalktlssrqvvesvgnqmgvgkesdiyivaneegqq
falklhrlgrtsfrnlknkrdyhkyrhnvswlylsrlsamkefaymkalyerkfpvpkpi
dynrhavvmelingyplcqihhvedpasvydeamelivklanhglihgdfnefnlildes
dhitmidfpqmvstshpnaewyfdrdvkcikdffmkrfsyeselfptfkdirredtldve
vsasgytkemqaddellhplgpddknietk

    Sequence, based on observed residues (ATOM records):
    >6hk6E (E:)
gkvnvaklrymsrddfrvltavemgmknheivpgsliasiaslkhggcnkvlrelvkhkl
iawertktvqgyrltnagydylalktlssrqvvesvgnqmgvgkesdiyivaneegqqfa
lklhrlgrtsfrnlnvswlylsrlsamkefaymkalyerkfpvpkpidynrhavvmelin
gyplcqihhvedpasvydeamelivklanhglihgdfnefnlildesdhitmidfpqmvs
tshpnaewyfdrdvkcikdffmkrfsyeselfptfkdirredtldvevs

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6hk6F (F:)
smgkvnvaklrymsrddfrvltavemgmknheivpgsliasiaslkhggcnkvlrelvkh
kliawertktvqgyrltnagydylalktlssrqvvesvgnqmgvgkesdiyivaneegqq
falklhrlgrtsfrnlknkrdyhkyrhnvswlylsrlsamkefaymkalyerkfpvpkpi
dynrhavvmelingyplcqihhvedpasvydeamelivklanhglihgdfnefnlildes
dhitmidfpqmvstshpnaewyfdrdvkcikdffmkrfsyeselfptfkdirredtldve
vsasgytkemqaddellhplgpddknietk

    Sequence, based on observed residues (ATOM records):
    >6hk6F (F:)
mgkvnvaklrymsrddfrvltavemgmknheivpgsliasiaslggcnkvlrelvkhkli
awertktvqgyrltnagydylalktlssrqvvesvgnqmgvgkesdiyivaneegqqfal
klhrlgrtsfrnlhnvswlylsrlsamkefaymkalyerkfpvpkpidynrhavvmelin
gyplcqihhvedpasvydeamelivklanhglihgdfnefnlildesdhitmidfpqmvs
tshpnaewyfdrdvkcikdffmkrfsyeselfptfkdirredtldvevs

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6hk6G (G:)
smgkvnvaklrymsrddfrvltavemgmknheivpgsliasiaslkhggcnkvlrelvkh
kliawertktvqgyrltnagydylalktlssrqvvesvgnqmgvgkesdiyivaneegqq
falklhrlgrtsfrnlknkrdyhkyrhnvswlylsrlsamkefaymkalyerkfpvpkpi
dynrhavvmelingyplcqihhvedpasvydeamelivklanhglihgdfnefnlildes
dhitmidfpqmvstshpnaewyfdrdvkcikdffmkrfsyeselfptfkdirredtldve
vsasgytkemqaddellhplgpddknietk

    Sequence, based on observed residues (ATOM records):
    >6hk6G (G:)
vaklrymsrddfrvltavemgmknheivpgsliasiascnkvlrelvkhkliawertktv
qgyrltnagydylalktlssrqvvesvgnqmgvgkesdiyivaneegqqfalklhrlgsw
lylsrlsamkefaymkalyerkfpvpkpidynrhavvmelingyplcqihhvedpasvyd
eamelivklanhglihgdfnefnlildesdhitmidfpqmvstshpnaewyfdrdvkcik
dffmkrfsyeselfptfkdirredtldvevs

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6hk6H (H:)
smgkvnvaklrymsrddfrvltavemgmknheivpgsliasiaslkhggcnkvlrelvkh
kliawertktvqgyrltnagydylalktlssrqvvesvgnqmgvgkesdiyivaneegqq
falklhrlgrtsfrnlknkrdyhkyrhnvswlylsrlsamkefaymkalyerkfpvpkpi
dynrhavvmelingyplcqihhvedpasvydeamelivklanhglihgdfnefnlildes
dhitmidfpqmvstshpnaewyfdrdvkcikdffmkrfsyeselfptfkdirredtldve
vsasgytkemqaddellhplgpddknietk

    Sequence, based on observed residues (ATOM records):
    >6hk6H (H:)
kvnvaklrymsrddfrvltavemgmknheivpgsliasiaslkhggcnkvlrelvkhkli
awertktvqgyrltnagydylalktlssrqvvesvgnqmgvgkesdiyivaneegqqfal
klhrlgnvswlylsrlsamkefaymkalyerkfpvpkpidynrhavvmelingyplcqih
hvedpasvydeamelivklanhglihgdfnefnlildesdhitmidfpqmvstshpnaew
yfdrdvkcikdffmkrfsyeselfptfkdirredtldvevsa

  • Chain 'I':
    Sequence, based on SEQRES records:
    >6hk6I (I:)
smgkvnvaklrymsrddfrvltavemgmknheivpgsliasiaslkhggcnkvlrelvkh
kliawertktvqgyrltnagydylalktlssrqvvesvgnqmgvgkesdiyivaneegqq
falklhrlgrtsfrnlknkrdyhkyrhnvswlylsrlsamkefaymkalyerkfpvpkpi
dynrhavvmelingyplcqihhvedpasvydeamelivklanhglihgdfnefnlildes
dhitmidfpqmvstshpnaewyfdrdvkcikdffmkrfsyeselfptfkdirredtldve
vsasgytkemqaddellhplgpddknietk

    Sequence, based on observed residues (ATOM records):
    >6hk6I (I:)
gkvnvaklrymsrddfrvltavemgmknheivpgsliasiaslkhggcnkvlrelvkhkl
iawertktvqgyrltnagydylalktlssrqvvesvgnqmgvgkesdiyivaneegqqfa
lklhrlgrtsfrnlhnvswlylsrlsamkefaymkalyerkfpvpkpidynrhavvmeli
ngyplcqihhvedpasvydeamelivklanhglihgdfnefnlildesdhitmidfpqmv
stshpnaewyfdrdvkcikdffmkrfsyeselfptfkdirredtldve

  • Chain 'J':
    Sequence, based on SEQRES records:
    >6hk6J (J:)
smgkvnvaklrymsrddfrvltavemgmknheivpgsliasiaslkhggcnkvlrelvkh
kliawertktvqgyrltnagydylalktlssrqvvesvgnqmgvgkesdiyivaneegqq
falklhrlgrtsfrnlknkrdyhkyrhnvswlylsrlsamkefaymkalyerkfpvpkpi
dynrhavvmelingyplcqihhvedpasvydeamelivklanhglihgdfnefnlildes
dhitmidfpqmvstshpnaewyfdrdvkcikdffmkrfsyeselfptfkdirredtldve
vsasgytkemqaddellhplgpddknietk

    Sequence, based on observed residues (ATOM records):
    >6hk6J (J:)
gkvnvaklrymsrddfrvltavemgmknheivpgsliasiaslkhggcnkvlrelvkhkl
iawertktvqgyrltnagydylalktlssrqvvesvgnqmgvgkesdiyivaneegqqfa
lklhrlgrtsfrnlhnvswlylsrlsamkefaymkalyerkfpvpkpidynrhavvmeli
ngyplcqihhvedpasvydeamelivklanhglihgdfnefnlildesdhitmidfpqmv
stshpnaewyfdrdvkcikdffmkrfsyeselfptfkdirredtldvevs