PDB entry 6hj2
View 6hj2 on RCSB PDB site
Description: Crystal structure of hPXR in complex with dabrafenib
Class: nuclear protein
Keywords: pregnane X receptor anti-cancer drug endocrine disruptor nuclear receptor, NUCLEAR PROTEIN
Deposited on
2018-08-31, released
2020-03-25
The last revision prior to the SCOPe 2.08 freeze date was dated
2020-03-25, with a file datestamp of
2020-03-20.
Experiment type: XRAY
Resolution: 2.28 Å
R-factor: N/A
AEROSPACI score: 0.25
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Nuclear receptor subfamily 1 group I member 2
Species: Homo sapiens [TaxId:9606]
Gene: NR1I2, PXR
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6hj2a_ - Heterogens: P06, IPA, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>6hj2A (A:)
mkkghhhhhhgsertgtqplgvqglteeqrmmirelmdaqmktfdttfshfknfrlpgvl
ssgcelpeslqapreeaakwsqvrkdlcslkvslqlrgedgsvwnykppadsggkeifsl
lphmadmstymfkgiisfakvisyfrdlpiedqisllkgaafelcqlrfntvfnaetgtw
ecgrlsycledtaggfqqlllepmlkfhymlkklqlheeeyvlmqaislfspdrpgvlqh
rvvdqlqeqfaitlksyiecnrpqpahrflflkimamltelrsinaqhtqrllriqdihp
fatplmqelfgitgs
Sequence, based on observed residues (ATOM records): (download)
>6hj2A (A:)
vqglteeqrmmirelmdaqmktfdttfshfknfrlpgvaakwsqvrkdlcslkvslqlrg
edgsvwnykppadsggkeifsllphmadmstymfkgiisfakvisyfrdlpiedqisllk
gaafelcqlrfntvfnaetgtwecgrlsycledtfqqlllepmlkfhymlkklqlheeey
vlmqaislfspdrpgvlqhrvvdqlqeqfaitlksyiecnrpqpahrflflkimamltel
rsinaqhtqrllriqdihpfatplmqelfgitgs