PDB entry 6hil

View 6hil on RCSB PDB site
Description: X-ray structure of TEAD1(Y421H mutant) complexed with YAP(wildtype): Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson's chorioretinal atrophy
Class: transcription
Keywords: other, transcription factor, transcription
Deposited on 2018-08-30, released 2019-04-03
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-03-04, with a file datestamp of 2020-02-28.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transcriptional enhancer factor TEF-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TEAD1, TCF13, TEF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28347 (Start-217)
      • engineered mutation (213)
    Domains in SCOPe 2.08: d6hila_
  • Chain 'B':
    Compound: Transcriptional enhancer factor TEF-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TEAD1, TCF13, TEF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28347 (Start-217)
      • engineered mutation (213)
    Domains in SCOPe 2.08: d6hilb_
  • Chain 'C':
    Compound: Transcriptional enhancer factor TEF-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TEAD1, TCF13, TEF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28347 (Start-217)
      • engineered mutation (213)
    Domains in SCOPe 2.08: d6hilc_
  • Chain 'D':
    Compound: Transcriptional enhancer factor TEF-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TEAD1, TCF13, TEF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28347 (Start-217)
      • engineered mutation (213)
    Domains in SCOPe 2.08: d6hild_
  • Chain 'L':
    Compound: Transcriptional coactivator YAP1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'M':
    Compound: Transcriptional coactivator YAP1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'N':
    Compound: Transcriptional coactivator YAP1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'O':
    Compound: Transcriptional coactivator YAP1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: MYR, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6hilA (A:)
grsigttklrlvefsafleqqrdpdsynkhlfvhighanhsysdpllesvdirqiydkfp
ekkgglkelfgkgpqnafflvkfwadlncniqddagafygvtsqyessenmtvtcstkvc
sfgkqvvekveteyarfengrfvyrinrspmceyminfihklkhlpekymmnsvlenfti
llvvtnrdtqetllcmacvfevsnsehgaqhhihrlvk

    Sequence, based on observed residues (ATOM records): (download) 
    >6hilA (A:)
igttklrlvefsafleqqrdpdsynkhlfvhiglesvdirqiydkfpekkgglkelfgkg
pqnafflvkfwadlncniagafygvtsqyessenmtvtcstkvcsfgkqvvekveteyar
fengrfvyrinrspmceyminfihklkhlpekymmnsvlenftillvvtnrdtqetllcm
acvfevsnsehgaqhhihrlvk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6hilB (B:)
grsigttklrlvefsafleqqrdpdsynkhlfvhighanhsysdpllesvdirqiydkfp
ekkgglkelfgkgpqnafflvkfwadlncniqddagafygvtsqyessenmtvtcstkvc
sfgkqvvekveteyarfengrfvyrinrspmceyminfihklkhlpekymmnsvlenfti
llvvtnrdtqetllcmacvfevsnsehgaqhhihrlvk

    Sequence, based on observed residues (ATOM records): (download) 
    >6hilB (B:)
igttklrlvefsafleqqrdpdsynkhlfvhigllesvdirqiydkfpekkgglkelfgk
gpqnafflvkfwadlncniagafygvtsqyessenmtvtcstkvcsfgkqvvekveteya
rfengrfvyrinrspmceyminfihklkhlpekymmnsvlenftillvvtnrdtqetllc
macvfevsnsehgaqhhihrlvk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6hilC (C:)
grsigttklrlvefsafleqqrdpdsynkhlfvhighanhsysdpllesvdirqiydkfp
ekkgglkelfgkgpqnafflvkfwadlncniqddagafygvtsqyessenmtvtcstkvc
sfgkqvvekveteyarfengrfvyrinrspmceyminfihklkhlpekymmnsvlenfti
llvvtnrdtqetllcmacvfevsnsehgaqhhihrlvk

    Sequence, based on observed residues (ATOM records): (download) 
    >6hilC (C:)
igttklrlvefsafleqqrdpdsynkhlfvhigllesvdirqiydkfpekkgglkelfgk
gpqnafflvkfwadlncniagafygvtsqyessenmtvtcstkvcsfgkqvvekveteya
rfengrfvyrinrspmceyminfihklkhlpekymmnsvlenftillvvtnrdtqetllc
macvfevsnsehgaqhhihrlvk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6hilD (D:)
grsigttklrlvefsafleqqrdpdsynkhlfvhighanhsysdpllesvdirqiydkfp
ekkgglkelfgkgpqnafflvkfwadlncniqddagafygvtsqyessenmtvtcstkvc
sfgkqvvekveteyarfengrfvyrinrspmceyminfihklkhlpekymmnsvlenfti
llvvtnrdtqetllcmacvfevsnsehgaqhhihrlvk

    Sequence, based on observed residues (ATOM records): (download) 
    >6hilD (D:)
igttklrlvefsafleqqrdpdsynkhlfvhigllesvdirqiydkfpekkgglkelfgk
gpqnafflvkfwadlncniagafygvtsqyessenmtvtcstkvcsfgkqvvekveteya
rfengrfvyrinrspmceyminfihklkhlpekymmnsvlenftillvvtnrdtqetllc
macvfevsnsehgaqhhihrlvk

  • Chain 'L':
    No sequence available.

  • Chain 'M':
    No sequence available.

  • Chain 'N':
    No sequence available.

  • Chain 'O':
    No sequence available.