PDB entry 6hik

View 6hik on RCSB PDB site
Description: x-ray structure of tead4(y429h) mutant) complexed with yap (wildtype): molecular and structural characterization of a tead mutation at the origin of sveinsson's chorioretinal atrophy
Deposited on 2018-08-30, released 2019-04-03
The last revision was dated 2019-10-09, with a file datestamp of 2019-10-04.
Experiment type: XRAY
Resolution: 1.65 Å
R-factor: N/A
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transcriptional enhancer factor TEF-3
    Species: Homo sapiens [TaxId:9606]
    Gene: TEAD4, RTEF1, TCF13L1, TEF3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15561 (0-218)
      • engineered mutation (213)
  • Chain 'L':
    Compound: Transcriptional coactivator YAP1
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: MYR, PO4, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6hikA (A:)
grsvassklwmlefsafleqqqdpdtynkhlfvhigqsspsysdpyleavdirqiydkfp
ekkgglkdlfergpsnafflvkfwadlntniedegssfygvssqyespenmiitcstkvc
sfgkqvvekveteyaryenghysyrihrsplceyminfihklkhlpekymmnsvlenfti
lqvvtnrdtqetllciayvfevsasehgaqhhihrlvke

    Sequence, based on observed residues (ATOM records):
    >6hikA (A:)
grsvassklwmlefsafleqqqdpdtynkhlfvhigqsspsysdpyleavdirqiydkfp
ekkgglkdlfergpsnafflvkfwadlntngssfygvssqyespenmiitcstkvcsfgk
qvvekveteyaryenghysyrihrsplceyminfihklkhlpekymmnsvlenftilqvv
tnrdtqetllciayvfevsasehgaqhhihrlvke

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records:
    >6hikL (L:)
dsetdlealfnavmnpktanvpqtvpmrlrklpdsffkpp