PDB entry 6hhc

View 6hhc on RCSB PDB site
Description: Allosteric Inhibition as a new mode of Action for BAY 1213790, a Neutralizing Antibody Targeting the Activated form of Coagulation Factor XI
Class: blood clotting
Keywords: fxia antibody fab, blood clotting, blood clotting-immune complex
Deposited on 2018-08-27, released 2019-09-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Coagulation factor XI
    Species: Homo sapiens [TaxId:9606]
    Gene: F11
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03951 (0-End)
      • engineered mutation (112)
    Domains in SCOPe 2.08: d6hhca_
  • Chain 'H':
    Compound: FXIa Antibody FAB Heavy Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6HHC (0-End)
    Domains in SCOPe 2.08: d6hhch_
  • Chain 'L':
    Compound: FXIa Antibody FAB Light Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6HHC
    Domains in SCOPe 2.08: d6hhcl1, d6hhcl2
  • Heterogens: SO4, DMS

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6hhcA (A:)
ivggtasvrgewpwqvtlhttsptqrhlcggsiignqwiltaahcfygvespkilrvysg
ilnqseikedtsffgvqeiiihdqykmaesgydiallklettvnytdsqrpislpskgdr
nviytdcwvtgwgyrklrdkiqntlqkakiplvtneecqkryrghkithkmicagyregg
kdackgdsggplsckhnevwhlvgitswgegcaqrerpgvytnvveyvdwilektqav

    Sequence, based on observed residues (ATOM records): (download) 
    >6hhcA (A:)
ivggtasvrgewpwqvtlhttsptqrhlcggsiignqwiltaahcfygvespkilrvysg
ilnqseikedtsffgvqeiiihdqykmaesgydiallklettvnytdsqrpislpsytdc
wvtgwgyrklrdkiqntlqkakiplvtneecqkryrghkithkmicagyreggkdackgd
sggplsckhnevwhlvgitswgegcaqrerpgvytnvveyvdwilektq

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6hhcH (H:)
evqllesggglvqpggslrlscaasgftfsqygmdwvrqapgkglewvsgigpsggstvy
adsvkgrftisrdnskntlylqmnslraedtavyyctrggpyyyygmdvwgqgttvtvss
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkth

    Sequence, based on observed residues (ATOM records): (download) 
    >6hhcH (H:)
evqllesggglvqpggslrlscaasgftfsqygmdwvrqapgkglewvsgigpsggstvy
adsvkgrftisrdnskntlylqmnslraedtavyyctrggpyyyygmdvwgqgttvtvss
astkgpsvfplapgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslss
vvtvpssslgtqtyicnvnhkpsntkvdkkvepk

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6hhcL (L:)
aqdiqmtqspsslsasvgdrvtitcqasqdisnylnwyqqkpgkapklliydasnletgv
psrfsgsgsgtdftftisslqpediatyycqqansfpvtfgggtkveikrtvaapsvfif
ppsdeqlksgtasvvcllnnfysreakvqwkvdnalqsgnsqesvteqdskdstyslsst
ltlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6hhcL (L:)
diqmtqspsslsasvgdrvtitcqasqdisnylnwyqqkpgkapklliydasnletgvps
rfsgsgsgtdftftisslqpediatyycqqansfpvtfgggtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfysreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrge