PDB entry 6hgn

View 6hgn on RCSB PDB site
Description: crystal structure of alpha1-antichymotrypsin variant dbs-ii-allo-l55v: an allosterically controlled doxorubicin-binding serpin with an unprecedentedly high ligand release efficacy
Deposited on 2018-08-23, released 2019-05-29
The last revision was dated 2019-07-31, with a file datestamp of 2019-07-26.
Experiment type: XRAY
Resolution: 1.48 Å
R-factor: N/A
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: alpha-1-antichymotrypsin
    Species: Homo sapiens [TaxId:9606]
    Gene: SERPINA3, AACT, GIG24, GIG25
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01011 (Start-368)
      • engineered mutation (63)
      • engineered mutation (202)
      • engineered mutation (223)
      • engineered mutation (250)
      • engineered mutation (252)
      • engineered mutation (277-278)
      • engineered mutation (282)
      • engineered mutation (284-286)
      • engineered mutation (357)
      • engineered mutation (363-368)
  • Chain 'B':
    Compound: alpha-1-antichymotrypsin
    Species: Homo sapiens [TaxId:9606]
    Gene: SERPINA3, AACT, GIG24, GIG25
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01011
      • engineered mutation (21-23)
      • engineered mutation (25-26)
  • Heterogens: EDO, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6hgnA (A:)
mkhhhhhhmkqnspldeenltqenqdrgthvdrglasanvdfafslykqlvlkapdknvi
fspvsistalaflslgahnttlteilkglkfnltetseaeihqsfqhllrtlnqssdelq
lsmgnamfvkeqlslldrftedakrlygseafatdfqdsaaakklindyvkngtrgkitd
likdldsqtmmvlvnyiffkakfempfdpqdthqsrfylskkkyvmvpmmslhhltipyf
rdeelsctvvqlnytgnasalfilpdqdkmeeveamlsqetlsrffeslefreigelylp
kfsisrdynlndillqlgieeaftskadlsgitgarnlavsqvvhkavldvfeegtersa
atalevlfq

    Sequence, based on observed residues (ATOM records):
    >6hgnA (A:)
glasanvdfafslykqlvlkapdknvifspvsistalaflslgahnttlteilkglkfnl
tetseaeihqsfqhllrtlnqssdelqlsmgnamfvkeqlslldrftedakrlygseafa
tdfqdsaaakklindyvkngtrgkitdlikdldsqtmmvlvnyiffkakfempfdpqdth
qsrfylskkkyvmvpmmslhhltipyfrdeelsctvvqlngnasalfilpdqdkmeevea
mlsqetlsrffeslefreigelylpkfsisrdynlndillqlgieeaftskadlsgitga
rnlavsqvvhkavldvfeegtersaatalevlfq

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6hgnB (B:)
gplvetrtivrfnrpflmiivdnftwsiffmskvtnpkqa

    Sequence, based on observed residues (ATOM records):
    >6hgnB (B:)
tivrfnrpflmiivdnftwsiffmskvtnpkq