PDB entry 6hgm

View 6hgm on RCSB PDB site
Description: crystal structure of alpha1-antichymotrypsin variant newbg-iii-allo: an allosterically controlled new binding globulin with an unprecedentedly high ligand release efficacy
Deposited on 2018-08-23, released 2019-05-29
The last revision was dated 2019-07-31, with a file datestamp of 2019-07-26.
Experiment type: XRAY
Resolution: 1.37 Å
R-factor: N/A
AEROSPACI score: 0.55 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: alpha-1-antichymotrypsin
    Species: Homo sapiens [TaxId:9606]
    Gene: SERPINA3, AACT, GIG24, GIG25
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01011 (Start-368)
      • engineered mutation (63)
      • engineered mutation (250)
      • engineered mutation (252)
      • engineered mutation (259-260)
      • engineered mutation (277-278)
      • engineered mutation (282)
      • engineered mutation (285)
      • engineered mutation (357)
  • Chain 'B':
    Compound: alpha-1-antichymotrypsin
    Species: Homo sapiens [TaxId:9606]
    Gene: SERPINA3, AACT, GIG24, GIG25
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01011
      • engineered mutation (21-23)
      • engineered mutation (25-26)
  • Heterogens: CL, CA, EDO, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6hgmA (A:)
mkhhhhhhmkqnspldeenltqenqdrgthvdrglasanvdfafslykqlvlkapdknvi
fspvsistalaflslgahnttlteilkglkfnltetseaeihqsfqhllrtlnqssdelq
lsmgnamfvkeqlslldrftedakrlygseafatdfqdsaaakklindyvkngtrgkitd
likdldsqtmmvlvnyiffkakwempfdpqdthqsrfylskkkwvmvpmmslhhltipyf
rdeelsctvvqlnytgnasvffilpdqdkmeeveamlsretlarwgdslefreigelylp
kfsisrdynlndillqlgieeaftskadlsgitgarnlavsqvvhkavldvfeegtersa
atavkitll

    Sequence, based on observed residues (ATOM records):
    >6hgmA (A:)
lasanvdfafslykqlvlkapdknvifspvsistalaflslgahnttlteilkglkfnlt
etseaeihqsfqhllrtlnlqlsmgnamfvkeqlslldrftedakrlygseafatdfqds
aaakklindyvkngtrgkitdlikdldsqtmmvlvnyiffkakwempfdpqdthqsrfyl
skkkwvmvpmmslhhltipyfrdeelsctvvqlnytgnasvffilpdqdkmeeveamlsr
etlarwgdslefreigelylpkfsisrdynlndillqlgieeaftskadlsgitgarnla
vsqvvhkavldvfeegtersaatavkitll

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6hgmB (B:)
salvetrtivrfnrpflmiivdhftwsiffmskvtnpkqa

    Sequence, based on observed residues (ATOM records):
    >6hgmB (B:)
rtivrfnrpflmiivdhftwsiffmskvtnpkq