PDB entry 6hg8

View 6hg8 on RCSB PDB site
Description: crystal structure of the r460g disease-causing mutant of the human dihydrolipoamide dehydrogenase.
Deposited on 2018-08-22, released 2019-09-04
The last revision was dated 2019-09-04, with a file datestamp of 2019-08-30.
Experiment type: XRAY
Resolution: 1.76 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydrolipoyl dehydrogenase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: DLD, GCSL, LAD, PHE3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09622 (Start-495)
      • engineered mutation (481)
  • Chain 'B':
    Compound: Dihydrolipoyl dehydrogenase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: DLD, GCSL, LAD, PHE3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09622 (22-495)
      • expression tag (14-21)
      • engineered mutation (481)
  • Heterogens: FAD, SO4, TRS, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6hg8A (A:)
maswshpqfekgalevlfqgpgadqpidadvtvigsgpggyvaaikaaqlgfktvciekn
etlggtclnvgcipskallnnshyyhmahgkdfasrgiemsevrlnldkmmeqkstavka
ltggiahlfkqnkvvhvngygkitgknqvtatkadggtqvidtkniliatgsevtpfpgi
tidedtivsstgalslkkvpekmvvigagvigvelgsvwqrlgadvtaveflghvggvgi
dmeisknfqrilqkqgfkfklntkvtgatkksdgkidvsieaasggkaevitcdvllvci
grrpftknlgleelgieldprgripvntrfqtkipniyaigdvvagpmlahkaedegiic
vegmaggavhidyncvpsviythpevawvgkseeqlkeegieykvgkfpfaansraktna
dtdgmvkilgqkstdrvlgahilgpgagemvneaalaleygascediarvchahptlsea
fgeanlaasfgksinf

    Sequence, based on observed residues (ATOM records):
    >6hg8A (A:)
qpidadvtvigsgpggyvaaikaaqlgfktvcieknetlggtclnvgcipskallnnshy
yhmahgkdfasrgiemsevrlnldkmmeqkstavkaltggiahlfkqnkvvhvngygkit
gknqvtatkadggtqvidtkniliatgsevtpfpgitidedtivsstgalslkkvpekmv
vigagvigvelgsvwqrlgadvtaveflghvggvgidmeisknfqrilqkqgfkfklntk
vtgatkksdgkidvsieaasggkaevitcdvllvcigrrpftknlgleelgieldprgri
pvntrfqtkipniyaigdvvagpmlahkaedegiicvegmaggavhidyncvpsviythp
evawvgkseeqlkeegieykvgkfpfaansraktnadtdgmvkilgqkstdrvlgahilg
pgagemvneaalaleygascediarvchahptlseafgeanlaasfgksinf

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6hg8B (B:)
maswshpqfekgalevlfqgpgadqpidadvtvigsgpggyvaaikaaqlgfktvciekn
etlggtclnvgcipskallnnshyyhmahgkdfasrgiemsevrlnldkmmeqkstavka
ltggiahlfkqnkvvhvngygkitgknqvtatkadggtqvidtkniliatgsevtpfpgi
tidedtivsstgalslkkvpekmvvigagvigvelgsvwqrlgadvtaveflghvggvgi
dmeisknfqrilqkqgfkfklntkvtgatkksdgkidvsieaasggkaevitcdvllvci
grrpftknlgleelgieldprgripvntrfqtkipniyaigdvvagpmlahkaedegiic
vegmaggavhidyncvpsviythpevawvgkseeqlkeegieykvgkfpfaansraktna
dtdgmvkilgqkstdrvlgahilgpgagemvneaalaleygascediarvchahptlsea
fgeanlaasfgksinf

    Sequence, based on observed residues (ATOM records):
    >6hg8B (B:)
evlfqgpgadqpidadvtvigsgpggyvaaikaaqlgfktvcieknetlggtclnvgcip
skallnnshyyhmahgkdfasrgiemsevrlnldkmmeqkstavkaltggiahlfkqnkv
vhvngygkitgknqvtatkadggtqvidtkniliatgsevtpfpgitidedtivsstgal
slkkvpekmvvigagvigvelgsvwqrlgadvtaveflghvggvgidmeisknfqrilqk
qgfkfklntkvtgatkksdgkidvsieaasggkaevitcdvllvcigrrpftknlgleel
gieldprgripvntrfqtkipniyaigdvvagpmlahkaedegiicvegmaggavhidyn
cvpsviythpevawvgkseeqlkeegieykvgkfpfaansraktnadtdgmvkilgqkst
drvlgahilgpgagemvneaalaleygascediarvchahptlseafgeanlaasfgksi
nf