PDB entry 6hfa

View 6hfa on RCSB PDB site
Description: crystal structure of hdm2 in complex with a c-terminal triurea capped peptide chimera foldamer.
Deposited on 2018-08-21, released 2020-07-08
The last revision was dated 2021-01-20, with a file datestamp of 2021-01-15.
Experiment type: XRAY
Resolution: 1.79 Å
R-factor: N/A
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: E3 ubiquitin-protein ligase Mdm2
    Species: Homo sapiens [TaxId:9606]
    Gene: MDM2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q00987 (Start-97)
      • conflict (74)
  • Chain 'B':
    Compound: E3 ubiquitin-protein ligase Mdm2
    Species: Homo sapiens [TaxId:9606]
    Gene: MDM2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q00987 (Start-97)
      • conflict (74)
  • Chain 'C':
    Compound: lm266
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6HFA (0-End)
  • Chain 'D':
    Compound: lm266
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6HFA (0-End)
  • Heterogens: UCV, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6hfaA (A:)
ghmsqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydekqqh
ivycsndllgdlfgapsfsvkehrkiytmiyrnlvvvn

    Sequence, based on observed residues (ATOM records):
    >6hfaA (A:)
etlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivycsndllgd
lfgapsfsvkehrkiytmiyrnlvvvn

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6hfaB (B:)
ghmsqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydekqqh
ivycsndllgdlfgapsfsvkehrkiytmiyrnlvvvn

    Sequence, based on observed residues (ATOM records):
    >6hfaB (B:)
etlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivycsndllgd
lfgapsfsvkehrkiytmiyrnlvvvn

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6hfaC (C:)
tsfaeywxxx

    Sequence, based on observed residues (ATOM records):
    >6hfaC (C:)
tsfaeywxx

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6hfaD (D:)
tsfaeywxxx

    Sequence, based on observed residues (ATOM records):
    >6hfaD (D:)
tsfaeywxx