PDB entry 6hep

View 6hep on RCSB PDB site
Description: crystal structure of human 14-3-3 beta in complex with cftr r-domain peptide ps753-ps768
Deposited on 2018-08-20, released 2018-10-24
The last revision was dated 2018-11-07, with a file datestamp of 2018-11-02.
Experiment type: XRAY
Resolution: 1.86 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 14-3-3 protein beta/alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: Ywhab
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: 14-3-3 protein beta/alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: Ywhab
    Database cross-references and differences (RAF-indexed):
    • Uniprot P31946 (3-234)
      • initiating methionine (0)
      • expression tag (1-2)
  • Chain 'C':
    Compound: 14-3-3 protein beta/alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: Ywhab
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: 14-3-3 protein beta/alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: Ywhab
    Database cross-references and differences (RAF-indexed):
    • Uniprot P31946 (3-234)
      • initiating methionine (0)
      • expression tag (1-2)
  • Chain 'E':
    Compound: Cystic fibrosis transmembrane conductance regulator
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Cystic fibrosis transmembrane conductance regulator
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ETE, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6hepA (A:)
mgsmtmdkselvqkaklaeqaeryddmaaamkavteqghelsneernllsvayknvvgar
rsswrvissieqkternekkqqmgkeyrekieaelqdicndvlelldkylipnatqpesk
vfylkmkgdyfrylsevasgdnkqttvsnsqqayqeafeiskkemqpthpirlglalnfs
vfyyeilnspekacslaktafdeaiaeldtlneesykdstlimqllrdnltlwts

    Sequence, based on observed residues (ATOM records):
    >6hepA (A:)
mdkselvqkaklaeqaeryddmaaamkavteqghelsneernllsvayknvvgarrsswr
vissieqkternekkqqmgkeyrekieaelqdicndvlelldkylipnatqpeskvfylk
mkgdyfrylsevasgdnkqttvsnsqqayqeafeiskkemqpthpirlglalnfsvfyye
ilnspekacslaktafdeaiaeldtlneesykdstlimqllrdnltlwts

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records:
    >6hepB (B:)
mgsmtmdkselvqkaklaeqaeryddmaaamkavteqghelsneernllsvayknvvgar
rsswrvissieqkternekkqqmgkeyrekieaelqdicndvlelldkylipnatqpesk
vfylkmkgdyfrylsevasgdnkqttvsnsqqayqeafeiskkemqpthpirlglalnfs
vfyyeilnspekacslaktafdeaiaeldtlneesykdstlimqllrdnltlwts

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6hepC (C:)
mgsmtmdkselvqkaklaeqaeryddmaaamkavteqghelsneernllsvayknvvgar
rsswrvissieqkternekkqqmgkeyrekieaelqdicndvlelldkylipnatqpesk
vfylkmkgdyfrylsevasgdnkqttvsnsqqayqeafeiskkemqpthpirlglalnfs
vfyyeilnspekacslaktafdeaiaeldtlneesykdstlimqllrdnltlwts

    Sequence, based on observed residues (ATOM records):
    >6hepC (C:)
mdkselvqkaklaeqaeryddmaaamkavteqghelsneernllsvayknvvgarrsswr
vissieqkternekkqqmgkeyrekieaelqdicndvlelldkylipnatqpeskvfylk
mkgdyfrylsevasgdnkqttvsnsqqayqeafeiskkemqpthpirlglalnfsvfyye
ilnspekacslaktafdeaiaeldtlneesykdstlimqllrdnltlwt

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6hepD (D:)
mgsmtmdkselvqkaklaeqaeryddmaaamkavteqghelsneernllsvayknvvgar
rsswrvissieqkternekkqqmgkeyrekieaelqdicndvlelldkylipnatqpesk
vfylkmkgdyfrylsevasgdnkqttvsnsqqayqeafeiskkemqpthpirlglalnfs
vfyyeilnspekacslaktafdeaiaeldtlneesykdstlimqllrdnltlwts

    Sequence, based on observed residues (ATOM records):
    >6hepD (D:)
mgsmtmdkselvqkaklaeqaeryddmaaamkavteqghelsneernllsvayknvvgar
rsswrvissieqktqqmgkeyrekieaelqdicndvlelldkylipnatqpeskvfylkm
kgdyfrylsevasgdnkqttvsnsqqayqeafeiskkemqpthpirlglalnfsvfyyei
lnspekacslaktafdeaiaelkdstlimqllrdnltlwts

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6hepE (E:)
ailprisvistgptlqarrrqsvlnlmt

    Sequence, based on observed residues (ATOM records):
    >6hepE (E:)
isvirrrqsvlnlmt

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6hepF (F:)
ailprisvistgptlqarrrqsvlnlmt

    Sequence, based on observed residues (ATOM records):
    >6hepF (F:)
isvirrrqsvlnlmt