PDB entry 6hcw

View 6hcw on RCSB PDB site
Description: Crystal Structure of Lysyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-lysine and a difluoro cyclohexyl chromone ligand
Class: transferase
Keywords: adenylyltransferase activity, tRNA binding, ligase, transferase
Deposited on 2018-08-16, released 2019-04-03
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-04-17, with a file datestamp of 2019-04-12.
Experiment type: XRAY
Resolution: 1.46 Å
R-factor: N/A
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lysine--tRNA ligase
    Species: Cryptosporidium parvum (strain Iowa II) [TaxId:353152]
    Gene: cgd4_2370
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5CR27 (21-End)
      • expression tag (20)
    Domains in SCOPe 2.08: d6hcwa1, d6hcwa2, d6hcwa3
  • Chain 'B':
    Compound: Lysine--tRNA ligase
    Species: Cryptosporidium parvum (strain Iowa II) [TaxId:353152]
    Gene: cgd4_2370
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5CR27 (21-End)
      • expression tag (20)
    Domains in SCOPe 2.08: d6hcwb1, d6hcwb2, d6hcwb3
  • Heterogens: LYS, FYB, TRS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6hcwA (A:)
mahhhhhhmgtleaqtqgpgshytdnrykmmecikdagrpfyphkfkismslpayalkyg
nvengyidkdttlslsgrvtsirssssklifydifceeqkvqiianimehdistgefsvs
hseirrgdvvgftgfpgkskrgelslfsksvvllspcyhmlptaisglkdqevryrqryl
dlmlneesrkvfklrsraikyirnyfdrlgflevetpmlnmiyggaaarpfityhnelet
qlymriapelylkqlivggldkvyeigknfrnegidlthnpeftamefymayadyydlmd
lteelisglvleihgslkipyhpdgpegkcieidfttpwkrfsfveeiesglgeklkrpl
dsqenidfmvemcekheielphprtaaklldklaghfvetkctnpsfiidhpqtmsplak
whrekpemterfelfvlgkelcnaytelneplqqrkffeqqadakasgdveacpidetfc
lalehglpptggwglgidrlimfladknnikevilfpamrnvkqnaqhsnqhsgn

    Sequence, based on observed residues (ATOM records): (download) 
    >6hcwA (A:)
shytdnrykmmecikdagrpfyphkfkismslpayalkygnvengyidkdttlslsgrvt
sirssssklifydifceeqkvqiianimehdistgefsvshseirrgdvvgftgfpgksk
rgelslfsksvvllspcyhmlptaisglkdqevryrqryldlmlneesrkvfklrsraik
yirnyfdrlgflevetpmlnmiyggaaarpfityhneletqlymriapelylkqlivggl
dkvyeigknfrnegidlthnpeftamefymayadyydlmdlteelisglvleihgslkip
yhpdgpegkcieidfttpwkrfsfveeiesglgeklkrpldsqenidfmvemcekheiel
phprtaaklldklaghfvetkctnpsfiidhpqtmsplakwhrekpemterfelfvlgke
lcnaytelneplqqrkffeqqadakasgdveacpidetfclalehglpptggwglgidrl
imfladknnikevilfpamrn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6hcwB (B:)
mahhhhhhmgtleaqtqgpgshytdnrykmmecikdagrpfyphkfkismslpayalkyg
nvengyidkdttlslsgrvtsirssssklifydifceeqkvqiianimehdistgefsvs
hseirrgdvvgftgfpgkskrgelslfsksvvllspcyhmlptaisglkdqevryrqryl
dlmlneesrkvfklrsraikyirnyfdrlgflevetpmlnmiyggaaarpfityhnelet
qlymriapelylkqlivggldkvyeigknfrnegidlthnpeftamefymayadyydlmd
lteelisglvleihgslkipyhpdgpegkcieidfttpwkrfsfveeiesglgeklkrpl
dsqenidfmvemcekheielphprtaaklldklaghfvetkctnpsfiidhpqtmsplak
whrekpemterfelfvlgkelcnaytelneplqqrkffeqqadakasgdveacpidetfc
lalehglpptggwglgidrlimfladknnikevilfpamrnvkqnaqhsnqhsgn

    Sequence, based on observed residues (ATOM records): (download) 
    >6hcwB (B:)
shytdnrykmmecikdagrpfyphkfkismslpayalkygnvengyidkdttlslsgrvt
sirssssklifydifceeqkvqiianimehdistgefsvshseirrgdvvgftgfpgksk
rgelslfsksvvllspcyhmlptaiqevryrqryldlmlneesrkvfklrsraikyirny
fdrlgflevetpmlnmiyggaaarpfityhneletqlymriapelylkqlivggldkvye
igknfrnegidlthnpeftamefymayadyydlmdlteelisglvleihgslkipyhpdg
pegkcieidfttpwkrfsfveeiesglgeklkrpldsqenidfmvemcekheielphprt
aaklldklaghfvetkctnpsfiidhpqtmsplakwhrekpemterfelfvlgkelcnay
telneplqqrkffeqqadakasgdveacpidetfclalehglpptggwglgidrlimfla
dknnikevilfpamrn