PDB entry 6hco

View 6hco on RCSB PDB site
Description: cryo-em structure of the abcg2 e211q mutant bound to estrone 3-sulfate and 5d3-fab
Deposited on 2018-08-15, released 2018-11-07
The last revision was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: EM
Resolution: 3.58 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ATP-binding cassette sub-family G member 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ABCG2, ABCP, BCRP, BCRP1, MXR
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UNQ0
      • engineered mutation (219)
  • Chain 'B':
    Compound: ATP-binding cassette sub-family G member 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ABCG2, ABCP, BCRP, BCRP1, MXR
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UNQ0
      • engineered mutation (219)
  • Chain 'C':
    Compound: 5D3-Fab light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6HCO (0-End)
  • Chain 'D':
    Compound: 5D3-Fab heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6HCO
  • Chain 'E':
    Compound: 5D3-Fab light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6HCO (0-End)
  • Chain 'F':
    Compound: 5D3-Fab heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6HCO
  • Heterogens: FY5

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6hcoA (A:)
dykddddkgssssnvevfipvsqgntngfpatasndlkaftegavlsfhnicyrvklksg
flpcrkpvekeilsningimkpglnailgptgggksslldvlaarkdpsglsgdvlinga
prpanfkcnsgyvvqddvvmgtltvrenlqfsaalrlattmtnheknerinrviqelgld
kvadskvgtqfirgvsggerkrtsigmelitdpsilfldqpttgldsstanavllllkrm
skqgrtiifsihqprysifklfdsltllasgrlmfhgpaqealgyfesagyhceaynnpa
dffldiingdstavalnreedfkateiiepskqdkplieklaeiyvnssfyketkaelhq
lsggekkkkitvfkeisyttsfchqlrwvskrsfknllgnpqasiaqiivtvvlglviga
iyfglkndstgiqnragvlfflttnqcfssvsavelfvvekklfiheyisgyyrvssyfl
gkllsdllpmrmlpsiiftcivyfmlglkpkadaffvmmftlmmvaysassmalaiaagq
svvsvatllmticfvfmmifsgllvnlttiaswlswlqyfsiprygftalqhneflgqnf
cpglnatgnnpcnyatctgeeylvkqgidlspwglwknhvalacmivifltiaylkllfl
kkys

    Sequence, based on observed residues (ATOM records):
    >6hcoA (A:)
avlsfhnicyrvkeilsningimkpglnailgptgggksslldvlaarkdpsglsgdvli
ngaprpanfkcnsgyvvqddvvmgtltvrenlqfsaalrlattmtnheknerinrviqel
gldkvadskvgtqfirgvsggerkrtsigmelitdpsilfldqpttgldsstanavllll
krmskqgrtiifsihqprysifklfdsltllasgrlmfhgpaqealgyfesagyhceayn
npadffldiingdlieklaeiyvnssfyketkaelhqlsgsfchqlrwvskrsfknllgn
pqasiaqiivtvvlglvigaiyfglkndstgiqnragvlfflttnqcfssvsavelfvve
kklfiheyisgyyrvssyflgkllsdllpmrmlpsiiftcivyfmlglkpkadaffvmmf
tlmmvaysassmalaiaagqsvvsvatllmticfvfmmifsgllvnlttiaswlswlqyf
siprygftalqhneflgqnfcpglnatgnnpcnyatctgeeylvkqgidlspwglwknhv
alacmivifltiaylkllflkky

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6hcoB (B:)
dykddddkgssssnvevfipvsqgntngfpatasndlkaftegavlsfhnicyrvklksg
flpcrkpvekeilsningimkpglnailgptgggksslldvlaarkdpsglsgdvlinga
prpanfkcnsgyvvqddvvmgtltvrenlqfsaalrlattmtnheknerinrviqelgld
kvadskvgtqfirgvsggerkrtsigmelitdpsilfldqpttgldsstanavllllkrm
skqgrtiifsihqprysifklfdsltllasgrlmfhgpaqealgyfesagyhceaynnpa
dffldiingdstavalnreedfkateiiepskqdkplieklaeiyvnssfyketkaelhq
lsggekkkkitvfkeisyttsfchqlrwvskrsfknllgnpqasiaqiivtvvlglviga
iyfglkndstgiqnragvlfflttnqcfssvsavelfvvekklfiheyisgyyrvssyfl
gkllsdllpmrmlpsiiftcivyfmlglkpkadaffvmmftlmmvaysassmalaiaagq
svvsvatllmticfvfmmifsgllvnlttiaswlswlqyfsiprygftalqhneflgqnf
cpglnatgnnpcnyatctgeeylvkqgidlspwglwknhvalacmivifltiaylkllfl
kkys

    Sequence, based on observed residues (ATOM records):
    >6hcoB (B:)
avlsfhnicyrvkeilsningimkpglnailgptgggksslldvlaarkdpsglsgdvli
ngaprpanfkcnsgyvvqddvvmgtltvrenlqfsaalrlattmtnheknerinrviqel
gldkvadskvgtqfirgvsggerkrtsigmelitdpsilfldqpttgldsstanavllll
krmskqgrtiifsihqprysifklfdsltllasgrlmfhgpaqealgyfesagyhceayn
npadffldiingdlieklaeiyvnssfyketkaelhqlsgsfchqlrwvskrsfknllgn
pqasiaqiivtvvlglvigaiyfglkndstgiqnragvlfflttnqcfssvsavelfvve
kklfiheyisgyyrvssyflgkllsdllpmrmlpsiiftcivyfmlglkpkadaffvmmf
tlmmvaysassmalaiaagqsvvsvatllmticfvfmmifsgllvnlttiaswlswlqyf
siprygftalqhneflgqnfcpglnatgnnpcnyatctgeeylvkqgidlspwglwknhv
alacmivifltiaylkllflkky

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6hcoC (C:)
divltqspssfsvslgdrvtisckasgyilnrlawyqqkpgnaprllisgatsletgfps
rfsgtgsgkdytlsisslqtedvgtyycqqywstpwtfgggtkleirradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records):
    >6hcoC (C:)
divltqspssfsvslgdrvtisckasgyilnrlawyqqkpgnaprllisgatsletgfps
rfsgtgsgkdytlsisslqtedvgtyycqqywstpwtfgggtkleir

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6hcoD (D:)
qvqlqesgpglvkpsqslsltctvtgfsitsdyawnwirqfpgkklewmgyinfdggtty
npslrgrisitrdtsknqfflqlrsvtpedtatyycatfygakgtldywgqgtsvtvssa
kttppsvyplapvcgdtsgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsdl
ytlsssvtvtsstwpsqsitcnvahpasstkvdkkieprgp

    Sequence, based on observed residues (ATOM records):
    >6hcoD (D:)
vqlqesgpglvkpsqslsltctvtgfsitsdyawnwirqfpgkklewmgyinfdggttyn
pslrgrisitrdtsknqfflqlrsvtpedtatyycatfygakgtldywgqgtsvtvss

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6hcoE (E:)
divltqspssfsvslgdrvtisckasgyilnrlawyqqkpgnaprllisgatsletgfps
rfsgtgsgkdytlsisslqtedvgtyycqqywstpwtfgggtkleirradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records):
    >6hcoE (E:)
divltqspssfsvslgdrvtisckasgyilnrlawyqqkpgnaprllisgatsletgfps
rfsgtgsgkdytlsisslqtedvgtyycqqywstpwtfgggtkleir

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6hcoF (F:)
qvqlqesgpglvkpsqslsltctvtgfsitsdyawnwirqfpgkklewmgyinfdggtty
npslrgrisitrdtsknqfflqlrsvtpedtatyycatfygakgtldywgqgtsvtvssa
kttppsvyplapvcgdtsgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsdl
ytlsssvtvtsstwpsqsitcnvahpasstkvdkkieprgp

    Sequence, based on observed residues (ATOM records):
    >6hcoF (F:)
vqlqesgpglvkpsqslsltctvtgfsitsdyawnwirqfpgkklewmgyinfdggttyn
pslrgrisitrdtsknqfflqlrsvtpedtatyycatfygakgtldywgqgtsvtvss