PDB entry 6hax

View 6hax on RCSB PDB site
Description: Crystal structure of PROTAC 2 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB
Class: gene regulation
Keywords: bromodomain, E3 Ubiquitin Protein Ligase, GENE REGULATION
Deposited on 2018-08-09, released 2019-06-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-07-03, with a file datestamp of 2019-06-28.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Probable global transcription activator SNF2L2
    Species: Homo sapiens [TaxId:9606]
    Gene: SMARCA2, BAF190B, BRM, SNF2A, SNF2L2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6haxa_
  • Chain 'B':
    Compound: von hippel-lindau disease tumor suppressor
    Species: Homo sapiens [TaxId:9606]
    Gene: VHL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6haxb_
  • Chain 'C':
    Compound: Elongin-C
    Species: Homo sapiens [TaxId:9606]
    Gene: ELOC, TCEB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15369 (1-96)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d6haxc1, d6haxc2
  • Chain 'D':
    Compound: Elongin-B
    Species: Homo sapiens [TaxId:9606]
    Gene: ELOB, TCEB2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6haxd_
  • Chain 'E':
    Compound: Probable global transcription activator SNF2L2
    Species: Homo sapiens [TaxId:9606]
    Gene: SMARCA2, BAF190B, BRM, SNF2A, SNF2L2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51531 (2-End)
      • expression tag (1)
    Domains in SCOPe 2.08: d6haxe1, d6haxe2
  • Chain 'F':
    Compound: von hippel-lindau disease tumor suppressor
    Species: Homo sapiens [TaxId:9606]
    Gene: VHL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6haxf_
  • Chain 'G':
    Compound: Elongin-C
    Species: Homo sapiens [TaxId:9606]
    Gene: ELOC, TCEB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15369 (1-96)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d6haxg1, d6haxg2
  • Chain 'H':
    Compound: Elongin-B
    Species: Homo sapiens [TaxId:9606]
    Gene: ELOB, TCEB2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6haxh_
  • Heterogens: FWZ, EDO, EPE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6haxA (A:)
smaeklspnppkltkqmnaiidtvinykdssgrqlsevfiqlpsrkelpeyyelirkpvd
fkkikerirnhkyrslgdlekdvmllchnaqtfnlegsqiyedsivlqsvfksarqkiak
eee

    Sequence, based on observed residues (ATOM records): (download) 
    >6haxA (A:)
lspnppkltkqmnaiidtvinykdssgrqlsevfiqlpsrkelpeyyelirkpvdfkkik
erirnhkyrslgdlekdvmllchnaqtfnlegsqiyedsivlqsvfksarqkiak

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6haxB (B:)
gsmeagrprpvlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihs
yrghlwlfrdagthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvk
penyrrldivrslyedledhpnvqkdlerltqeriahqrmgd

    Sequence, based on observed residues (ATOM records): (download) 
    >6haxB (B:)
rpvlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihsyrghlwlf
rdagthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvkpenyrrld
ivrslyedledhpnvqkdlerltqeriah

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6haxC (C:)
mmyvklissdghefivkrehaltsgtikamlsgpgqfaenetnevnfreipshvlskvcm
yftykvrytnssteipefpiapeialellmaanfldc

    Sequence, based on observed residues (ATOM records): (download) 
    >6haxC (C:)
mmyvklissdghefivkrehaltsgtikamlstnevnfreipshvlskvcmyftykvryt
nssteipefpiapeialellmaanfldc

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6haxD (D:)
mdvflmirrhkttiftdakesstvfelkrivegilkrppdeqrlykddqllddgktlgec
gftsqtarpqapatvglafraddtfealciepfssppelpdvmk

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6haxE (E:)
smaeklspnppkltkqmnaiidtvinykdssgrqlsevfiqlpsrkelpeyyelirkpvd
fkkikerirnhkyrslgdlekdvmllchnaqtfnlegsqiyedsivlqsvfksarqkiak
eee

    Sequence, based on observed residues (ATOM records): (download) 
    >6haxE (E:)
maeklspnppkltkqmnaiidtvinykdssgrqlsevfiqlpsrkelpeyyelirkpvdf
kkikerirnhkyrslgdlekdvmllchnaqtfnlegsqiyedsivlqsvfksarqkiake
e

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6haxF (F:)
gsmeagrprpvlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihs
yrghlwlfrdagthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvk
penyrrldivrslyedledhpnvqkdlerltqeriahqrmgd

    Sequence, based on observed residues (ATOM records): (download) 
    >6haxF (F:)
pvlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihsyrghlwlfr
dagthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvkpenyrrldi
vrslyedledhpnvqkdlerltqeriahq

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6haxG (G:)
mmyvklissdghefivkrehaltsgtikamlsgpgqfaenetnevnfreipshvlskvcm
yftykvrytnssteipefpiapeialellmaanfldc

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6haxH (H:)
mdvflmirrhkttiftdakesstvfelkrivegilkrppdeqrlykddqllddgktlgec
gftsqtarpqapatvglafraddtfealciepfssppelpdvmk