PDB entry 6h7k

View 6h7k on RCSB PDB site
Description: activated turkey beta1 adrenoceptor with bound agonist formoterol and nanobody nb80
Deposited on 2018-07-31, released 2018-10-17
Made obsolete by 6ibl on 2019-01-09

The last revision was dated 2019-01-09, with a file datestamp of 2019-01-04.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: beta-1 adrenergic receptor
    Species: Meleagris gallopavo [TaxId:9103]
    Gene: ADRB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07700 (5-End)
      • expression tag (2-4)
      • engineered mutation (29)
      • engineered mutation (51)
      • engineered mutation (77)
      • conflict (217)
      • engineered mutation (260)
      • engineered mutation (271)
      • engineered mutation (291)
  • Chain 'B':
    Compound: beta-1 adrenergic receptor
    Species: Meleagris gallopavo [TaxId:9103]
    Gene: ADRB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07700 (5-End)
      • expression tag (2-4)
      • engineered mutation (29)
      • engineered mutation (51)
      • engineered mutation (77)
      • conflict (217)
      • engineered mutation (260)
      • engineered mutation (271)
      • engineered mutation (291)
  • Chain 'C':
    Compound: Camelid antibody fragment Nb80
    Species: LAMA GLAMA [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 6H7K (Start-120)
  • Chain 'D':
    Compound: Camelid antibody fragment Nb80
    Species: LAMA GLAMA [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 6H7K (Start-120)
  • Chain 'E':
    Compound: Thioredoxin 1
    Species: Escherichia coli (strain K12) [TaxId:83333]
    Gene: trxA, fipA, tsnC, b3781, JW5856
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0AA25 (Start-107)
      • engineered mutation (31)
      • engineered mutation (34)
      • expression tag (108)
  • Chain 'F':
    Compound: Thioredoxin 1
    Species: Escherichia coli (strain K12) [TaxId:83333]
    Gene: trxA, fipA, tsnC, b3781, JW5856
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0AA25 (Start-107)
      • engineered mutation (31)
      • engineered mutation (34)
      • expression tag (108)
  • Heterogens: FVN, NA, 2CV, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6h7kA (A:)
aaakvmsllmalvvllivagnvlviaaigstqrlqtltnlfitslacadlvvgllvvpfg
atlvvrgtwlwgsflcelwtsldvlcvtasietlcviaidrylaitspfryqslmtrara
kviictvwaisalvsflpimmhwwrdedpqalkcyqdpgccdfvtnrayaiassiisfyi
pllimifvylrvyreakeqirkidraskrktsrvmamkehkalktlgiimgvftlcwlpf
flvnivnvfnrdlvpdwlfvafnwlgyansamnpiiycrspdfrkafkrllafprkadrr
lhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6h7kA (A:)
akvmsllmalvvllivagnvlviaaigstqrlqtltnlfitslacadlvvgllvvpfgat
lvvrgtwlwgsflcelwtsldvlcvtasietlcviaidrylaitspfryqslmtrarakv
iictvwaisalvsflpimmhwwrdedpqalkcyqdpgccdfvtnrayaiassiisfyipl
limifvylrvyreakeqirkidraskrktsrvmamkehkalktlgiimgvftlcwlpffl
vnivnvfnrdlvpdwlfvafnwlgyansamnpiiycrspdfrkafkrlla

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6h7kB (B:)
aaakvmsllmalvvllivagnvlviaaigstqrlqtltnlfitslacadlvvgllvvpfg
atlvvrgtwlwgsflcelwtsldvlcvtasietlcviaidrylaitspfryqslmtrara
kviictvwaisalvsflpimmhwwrdedpqalkcyqdpgccdfvtnrayaiassiisfyi
pllimifvylrvyreakeqirkidraskrktsrvmamkehkalktlgiimgvftlcwlpf
flvnivnvfnrdlvpdwlfvafnwlgyansamnpiiycrspdfrkafkrllafprkadrr
lhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6h7kB (B:)
akvmsllmalvvllivagnvlviaaigstqrlqtltnlfitslacadlvvgllvvpfgat
lvvrgtwlwgsflcelwtsldvlcvtasietlcviaidrylaitspfryqslmtrarakv
iictvwaisalvsflpimmhwwrdedpqalkcyqdpgccdfvtnrayaiassiisfyipl
limifvylrvyreakeqirkidrasamkehkalktlgiimgvftlcwlpfflvnivnvfn
rdlvpdwlfvafnwlgyansamnpiiycrspdfrkafkrllaf

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6h7kC (C:)
sqvqlqesggglvqaggslrlscaasgsifsintmgwyrqapgkqrelvaaihsggstny
ansvkgrftisrdnaantvylqmnslkpedtavyycnvkdygavlyeydywgqgtqvtvs
s

    Sequence, based on observed residues (ATOM records):
    >6h7kC (C:)
vqlqesggglvqaggslrlscaasgsifsintmgwyrqapgkqrelvaaihsggstnyan
svkgrftisrdnaantvylqmnslkpedtavyycnvkdygavlyeydywgqgtqvtvss

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6h7kD (D:)
sqvqlqesggglvqaggslrlscaasgsifsintmgwyrqapgkqrelvaaihsggstny
ansvkgrftisrdnaantvylqmnslkpedtavyycnvkdygavlyeydywgqgtqvtvs
s

    Sequence, based on observed residues (ATOM records):
    >6h7kD (D:)
qvqlqesggglvqaggslrlscaasgsifsintmgwyrqapgkqrelvaaihsggstnya
nsvkgrftisrdnaantvylqmnslkpedtavyycnvkdygavlyeydywgqgtqvtvss

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6h7kE (E:)
sdkiihltddsfdtdvlkadgailvdfwaewsgpskmiapildeiadeyqgkltvaklni
dqnpgtapkygirgiptlllfkngevaatkvgalskgqlkefldanlae

    Sequence, based on observed residues (ATOM records):
    >6h7kE (E:)
kiihltddsfdtdvlkadgailvdfwaewsgpskmiapildeiadeyqgkltvaklnidq
npgtapkygirgiptlllfkngevaatkvgalskgqlkefldanlae

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6h7kF (F:)
sdkiihltddsfdtdvlkadgailvdfwaewsgpskmiapildeiadeyqgkltvaklni
dqnpgtapkygirgiptlllfkngevaatkvgalskgqlkefldanlae

    Sequence, based on observed residues (ATOM records):
    >6h7kF (F:)
dkiihltddsfdtdvlkadgailvdfwaewsgpskmiapildeiadeyqgkltvaklnid
qnpgtapkygirgiptlllfkngevaatkvgalskgqlkefldanlae