SCOPe 2.08: Structural Classification of Proteins

PDB entry 6h6t

View 6h6t on RCSB PDB site
Description: Binary crystal structure of positively and negatively supercharged variants Ftn(pos) and Ftn(neg) from human heavy chain ferritin (propandiol condition, coordination number 8)
Class: oxidoreductase
Keywords: protein design, protein engineering, charged protein containers, binary protein structures, self-assembly, binary nanoparticle superlattices, oxidoreductase
Deposited on 2018-07-30, released 2019-08-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-08-14, with a file datestamp of 2019-08-09.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: ferritin heavy chain
Species: Homo sapiens [TaxId:9606]
Gene: FTH1, FTH, FTHL6, OK/SW-cl.84, PIG15
Database cross-references and differences (RAF-indexed):
- Uniprot P02794
  - engineered mutation (18)
  - engineered mutation (25)
  - engineered mutation (86)
  - engineered mutation (90)
  - engineered mutation (98)
  - engineered mutation (102)
  - engineered mutation (105)
  - engineered mutation (109)
  - engineered mutation (123)
  - engineered mutation (162)
Domains in SCOPe 2.08: d6h6ta_
Chain 'B':
Compound: ferritin heavy chain
Species: Homo sapiens [TaxId:9606]
Gene: FTH1, FTH, FTHL6, OK/SW-cl.84, PIG15
Database cross-references and differences (RAF-indexed):
- Uniprot P02794
  - engineered mutation (18)
  - engineered mutation (25)
  - engineered mutation (86)
  - engineered mutation (90)
  - engineered mutation (98)
  - engineered mutation (102)
  - engineered mutation (105)
  - engineered mutation (109)
  - engineered mutation (123)
  - engineered mutation (162)
Domains in SCOPe 2.08: d6h6tb_
Chain 'C':
Compound: ferritin heavy chain
Species: Homo sapiens [TaxId:9606]
Gene: FTH1, FTH, FTHL6, OK/SW-cl.84, PIG15
Database cross-references and differences (RAF-indexed):
- Uniprot P02794
  - engineered mutation (18)
  - engineered mutation (25)
  - engineered mutation (86)
  - engineered mutation (90)
  - engineered mutation (98)
  - engineered mutation (102)
  - engineered mutation (105)
  - engineered mutation (109)
  - engineered mutation (123)
  - engineered mutation (162)
Domains in SCOPe 2.08: d6h6tc_
Chain 'D':
Compound: ferritin heavy chain
Species: Homo sapiens [TaxId:9606]
Gene: FTH1, FTH, FTHL6, OK/SW-cl.84, PIG15
Database cross-references and differences (RAF-indexed):
- Uniprot P02794
  - engineered mutation (18)
  - engineered mutation (25)
  - engineered mutation (86)
  - engineered mutation (90)
  - engineered mutation (98)
  - engineered mutation (102)
  - engineered mutation (105)
  - engineered mutation (109)
  - engineered mutation (123)
  - engineered mutation (162)
Domains in SCOPe 2.08: d6h6td_
Chain 'E':
Compound: ferritin heavy chain
Species: Homo sapiens [TaxId:9606]
Gene: FTH1, FTH, FTHL6, OK/SW-cl.84, PIG15
Database cross-references and differences (RAF-indexed):
- Uniprot P02794
  - engineered mutation (18)
  - engineered mutation (25)
  - engineered mutation (86)
  - engineered mutation (90)
  - engineered mutation (98)
  - engineered mutation (102)
  - engineered mutation (105)
  - engineered mutation (109)
  - engineered mutation (123)
  - engineered mutation (162)
Domains in SCOPe 2.08: d6h6te_
Chain 'F':
Compound: ferritin heavy chain
Species: Homo sapiens [TaxId:9606]
Gene: FTH1, FTH, FTHL6, OK/SW-cl.84, PIG15
Database cross-references and differences (RAF-indexed):
- Uniprot P02794
  - engineered mutation (18)
  - engineered mutation (25)
  - engineered mutation (86)
  - engineered mutation (90)
  - engineered mutation (98)
  - engineered mutation (102)
  - engineered mutation (105)
  - engineered mutation (109)
  - engineered mutation (123)
  - engineered mutation (162)
Domains in SCOPe 2.08: d6h6tf_
Chain 'G':
Compound: ferritin heavy chain
Species: Homo sapiens [TaxId:9606]
Gene: FTH1, FTH, FTHL6, OK/SW-cl.84, PIG15
Database cross-references and differences (RAF-indexed):
- Uniprot P02794
  - engineered mutation (18)
  - engineered mutation (86)
  - engineered mutation (90)
  - engineered mutation (102)
  - engineered mutation (105)
Domains in SCOPe 2.08: d6h6tg_
Chain 'H':
Compound: ferritin heavy chain
Species: Homo sapiens [TaxId:9606]
Gene: FTH1, FTH, FTHL6, OK/SW-cl.84, PIG15
Database cross-references and differences (RAF-indexed):
- Uniprot P02794
  - engineered mutation (18)
  - engineered mutation (86)
  - engineered mutation (90)
  - engineered mutation (102)
  - engineered mutation (105)
Domains in SCOPe 2.08: d6h6th_
Chain 'I':
Compound: ferritin heavy chain
Species: Homo sapiens [TaxId:9606]
Gene: FTH1, FTH, FTHL6, OK/SW-cl.84, PIG15
Database cross-references and differences (RAF-indexed):
- Uniprot P02794
  - engineered mutation (18)
  - engineered mutation (86)
  - engineered mutation (90)
  - engineered mutation (102)
  - engineered mutation (105)
Domains in SCOPe 2.08: d6h6ti_
Chain 'J':
Compound: ferritin heavy chain
Species: Homo sapiens [TaxId:9606]
Gene: FTH1, FTH, FTHL6, OK/SW-cl.84, PIG15
Database cross-references and differences (RAF-indexed):
- Uniprot P02794
  - engineered mutation (18)
  - engineered mutation (86)
  - engineered mutation (90)
  - engineered mutation (102)
  - engineered mutation (105)
Domains in SCOPe 2.08: d6h6tj_
Chain 'K':
Compound: ferritin heavy chain
Species: Homo sapiens [TaxId:9606]
Gene: FTH1, FTH, FTHL6, OK/SW-cl.84, PIG15
Database cross-references and differences (RAF-indexed):
- Uniprot P02794
  - engineered mutation (18)
  - engineered mutation (86)
  - engineered mutation (90)
  - engineered mutation (102)
  - engineered mutation (105)
Domains in SCOPe 2.08: d6h6tk_
Chain 'L':
Compound: ferritin heavy chain
Species: Homo sapiens [TaxId:9606]
Gene: FTH1, FTH, FTHL6, OK/SW-cl.84, PIG15
Database cross-references and differences (RAF-indexed):
- Uniprot P02794
  - engineered mutation (18)
  - engineered mutation (86)
  - engineered mutation (90)
  - engineered mutation (102)
  - engineered mutation (105)
Domains in SCOPe 2.08: d6h6tl_
Heterogens: FE, ACT, MG, ZN, CL, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>6h6tA (A:)
mttastsqvrqnyhqdsekainrqirlelyasyvylsmsyyfdrddvalknfakyflhqs
heerehaeklmklqnqrggriflqdiqkpdkddwesglramekalklekkvnqsllelhk
latkkndphlcdfiethylneqvkaikelgdhvtnlrkmgaprsglaeylfdkhtlgdsd
nes