PDB entry 6h4z

View 6h4z on RCSB PDB site
Description: Crystal structure of human KDM5B in complex with compound 16a
Class: oxidoreductase
Keywords: Histone demethylase, Inhibitor, transcription, OXIDOREDUCTASE
Deposited on 2018-07-23, released 2019-06-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-06-12, with a file datestamp of 2019-06-07.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lysine-specific demethylase 5B,Lysine-specific demethylase 5B
    Species: Homo sapiens [TaxId:9606]
    Gene: KDM5B, JARID1B, PLU1, RBBP2H1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UGL1 (2-End)
      • expression tag (0-1)
    • Uniprot Q9UGL1 (82-End)
    Domains in SCOPe 2.08: d6h4za1, d6h4za2, d6h4za3
  • Heterogens: ZN, MN, FQ5, DMS, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6h4zA (A:)
smflpppecpvfepsweefadpfafihkirpiaeqtgickvrpppdwqppfacdvdklhf
tpriqrlneleaqtrvklggggardytlrtfgemadafksdyfnmpvhmvptelvekefw
rlvstieedvtveygadiaskefgsgfpvrdgkiklspeeeeyldsgwnlnnmpvmeqsv
lahitadicgmklpwlyvgmcfssfcwhiedhwsysinylhwgepktwygvpgyaaeqle
nvmkklapelfvsqpdllhqlvtimnpntlmthevpvyrtnqcagefvitfprayhsgfn
qgfnfaeavnfctvdwlplgrqcvehyrllhrycvfshdemickmaskadvldvvvastv
qkdmaimiedekalretvrklgvidsermdfellpdderqcvkckttcfmsaiscsckpg
llvclhhvkelcscppykyklryrytlddlypmmnalklraesynewalnvnealeakin
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    Sequence, based on observed residues (ATOM records): (download) 
    >6h4zA (A:)
smflpppecpvfepsweefadpfafihkirpiaeqtgickvrpppdwqppfacdvdklhf
tpriqrlneleaqtrvkardytlrtfgemadafksdyfnmpvhmvptelvekefwrlvst
ieedvtveygadiaskefgsgfpvrdgiklspeeeeyldsgwnlnnmpvmeqsvlahita
dicgmklpwlyvgmcfssfcwhiedhwsysinylhwgepktwygvpgyaaeqlenvmkkl
apelfvsqpdllhqlvtimnpntlmthevpvyrtnqcagefvitfprayhsgfnqgfnfa
eavnfctvdwlplgrqcvehyrllhrycvfshdemickmaskadvldvvvastvqkdmai
miedekalretvrklgvidsermdfellpdderqcvkckttcfmsaiscsckpgllvclh
hvkelcscppykyklryrytlddlypmmnalklraesy