PDB entry 6h4w

View 6h4w on RCSB PDB site
Description: Crystal structure of human KDM4A in complex with compound 19d
Class: oxidoreductase
Keywords: Histone demethylase, Inhibitor, transcription, OXIDOREDUCTASE
Deposited on 2018-07-23, released 2019-06-12
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-06-12, with a file datestamp of 2019-06-07.
Experiment type: XRAY
Resolution: 2.81 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: lysine-specific demethylase 4a
    Species: Homo sapiens [TaxId:9606]
    Gene: KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6h4wa_
  • Chain 'B':
    Compound: lysine-specific demethylase 4a
    Species: Homo sapiens [TaxId:9606]
    Gene: KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6h4wb_
  • Chain 'C':
    Compound: lysine-specific demethylase 4a
    Species: Homo sapiens [TaxId:9606]
    Gene: KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6h4wc_
  • Chain 'D':
    Compound: lysine-specific demethylase 4a
    Species: Homo sapiens [TaxId:9606]
    Gene: KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6h4wd_
  • Heterogens: FQQ, ZN, DMS, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6h4wA (A:)
    smasesetlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasy
    ddiddlvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeeler
    kywknltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfg
    mwktsfawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflr
    hkmtlisplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwiey
    gkqavlcscrkdmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaeflkesel
    

    Sequence, based on observed residues (ATOM records): (download)
    >6h4wA (A:)
    npsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddiddlvip
    apiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerkywknltfn
    ppiygadvngtlyekhvdewnigrlrtildlvekgvntpylyfgmwktsfawhtedmdly
    sinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkmtlisplmlkkygi
    pfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkqavlcscrvkismd
    vfvrkfqperyklwkagkdntvidhtlptpeaaeflk
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6h4wB (B:)
    smasesetlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasy
    ddiddlvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeeler
    kywknltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfg
    mwktsfawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflr
    hkmtlisplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwiey
    gkqavlcscrkdmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaeflkesel
    

    Sequence, based on observed residues (ATOM records): (download)
    >6h4wB (B:)
    setlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddidd
    lvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerkywkn
    ltfnppiygadvngtlyekhvdewnigrlrtildlvekvntpylyfgmwktsfawhtedm
    dlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkmtlisplmlkk
    ygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkqavlcscrmvk
    ismdvfvrkfqperyklwkagkdntvidhtlptpeaaefl
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >6h4wC (C:)
    smasesetlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasy
    ddiddlvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeeler
    kywknltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfg
    mwktsfawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflr
    hkmtlisplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwiey
    gkqavlcscrkdmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaeflkesel
    

    Sequence, based on observed residues (ATOM records): (download)
    >6h4wC (C:)
    sarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddiddlvipap
    iqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerkywknltfnpp
    iygadvngtlyekhvdewnigrlrtildlvekevntpylyfgmwktsfawhtedmdlysi
    nylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkmtlisplmlkkygipf
    dkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkqavlcscrmvkismdv
    fvrkfqperyklwkagkdntvidhtlptpeaaefl
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >6h4wD (D:)
    smasesetlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasy
    ddiddlvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeeler
    kywknltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfg
    mwktsfawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflr
    hkmtlisplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwiey
    gkqavlcscrkdmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaeflkesel
    

    Sequence, based on observed residues (ATOM records): (download)
    >6h4wD (D:)
    setlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddidd
    lvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerkywkn
    ltfnppiygadvngtlyekhvdewnigrlrtildlvegvntpylyfgmwktsfawhtedm
    dlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkmtlisplmlkk
    ygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkqavlcscrmvk
    ismdvfvrkfqperyklwkagkdntvidhtlptpeaaefl