PDB entry 6h4r

View 6h4r on RCSB PDB site
Description: Crystal structure of human KDM4A in complex with compound 17f
Class: oxidoreductase
Keywords: Histone demethylase, Inhibitor, transcription, OXIDOREDUCTASE
Deposited on 2018-07-23, released 2019-06-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-06-12, with a file datestamp of 2019-06-07.
Experiment type: XRAY
Resolution: 2.14 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: lysine-specific demethylase 4a
    Species: Homo sapiens [TaxId:9606]
    Gene: KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6h4ra_
  • Chain 'B':
    Compound: lysine-specific demethylase 4a
    Species: Homo sapiens [TaxId:9606]
    Gene: KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6h4rb_
  • Chain 'C':
    Compound: lysine-specific demethylase 4a
    Species: Homo sapiens [TaxId:9606]
    Gene: KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6h4rc_
  • Chain 'D':
    Compound: lysine-specific demethylase 4a
    Species: Homo sapiens [TaxId:9606]
    Gene: KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6h4rd_
  • Heterogens: FQB, ZN, DMS, GOL, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6h4rA (A:)
smasesetlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasy
ddiddlvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeeler
kywknltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfg
mwktsfawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflr
hkmtlisplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwiey
gkqavlcscrkdmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaeflkesel

    Sequence, based on observed residues (ATOM records): (download) 
    >6h4rA (A:)
etlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddiddl
vipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerkywknl
tfnppiygadvngtlyekhvdewnigrlrtildlvegvntpylyfgmwktsfawhtedmd
lysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkmtlisplmlkky
gipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkqavlcscrkdmv
kismdvfvrkfqperyklwkagkdntvidhtlptpeaaefl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6h4rB (B:)
smasesetlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasy
ddiddlvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeeler
kywknltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfg
mwktsfawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflr
hkmtlisplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwiey
gkqavlcscrkdmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaeflkesel

    Sequence, based on observed residues (ATOM records): (download) 
    >6h4rB (B:)
tlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddiddlv
ipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerkywknlt
fnppiygadvngtlyekhvdewnigrlrtildlveegvntpylyfgmwktsfawhtedmd
lysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkmtlisplmlkky
gipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkqavlcscrkdmv
kismdvfvrkfqperyklwkagkdntvidhtlptpeaaef

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6h4rC (C:)
smasesetlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasy
ddiddlvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeeler
kywknltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfg
mwktsfawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflr
hkmtlisplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwiey
gkqavlcscrkdmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaeflkesel

    Sequence, based on observed residues (ATOM records): (download) 
    >6h4rC (C:)
psarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddiddlvipa
piqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerkywknltfnp
piygadvngtlyekhvdewnigrlrtildlvekesgitgvntpylyfgmwktsfawhted
mdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkmtlisplmlk
kygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkqavlcscrmv
kismdvfvrkfqperyklwkagkdntvidhtlptpeaaefl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6h4rD (D:)
smasesetlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasy
ddiddlvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeeler
kywknltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfg
mwktsfawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflr
hkmtlisplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwiey
gkqavlcscrkdmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaeflkesel

    Sequence, based on observed residues (ATOM records): (download) 
    >6h4rD (D:)
psarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddiddlvipa
piqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerkywknltfnp
piygadvngtlyekhvdewnigrlrtildlvgvntpylyfgmwktsfawhtedmdlysin
ylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkmtlisplmlkkygipfd
kvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkqavlcscrmvkismdvf
vrkfqperyklwkagkdntvidhtlptpeaaefl