PDB entry 6h46

View 6h46 on RCSB PDB site
Description: Human KRAS in complex with darpin K13
Class: signaling protein
Keywords: GTP-ASE, darpin, KRAS signalling, SIGNALING PROTEIN
Deposited on 2018-07-20, released 2019-04-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-06-26, with a file datestamp of 2019-06-21.
Experiment type: XRAY
Resolution: 2.22 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (3-168)
      • expression tag (1-2)
      • engineered mutation (14)
    Domains in SCOPe 2.08: d6h46a1, d6h46a2
  • Chain 'B':
    Compound: darpin K13
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6H46 (0-155)
    Domains in SCOPe 2.08: d6h46b_
  • Heterogens: GDP, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6h46A (A:)
gshmteyklvvvgavgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldild
tagqeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnk
cdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkh

    Sequence, based on observed residues (ATOM records): (download) 
    >6h46A (A:)
shmteyklvvvgavgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildt
agqeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkc
dlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkh

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6h46B (B:)
mdlgkklleaaragqddevrilmangadvnasdrwgwtplhlaawwghleivevllkhga
dvnaadlhgqtplhlaamvghleivevllkygadvnakdtmgatplhlaaqsghleivev
llkngadvnaqdkfgktafdisidngnedlaeilqk