PDB entry 6h3c

View 6h3c on RCSB PDB site
Description: cryo-em structure of the brisc complex bound to shmt2
Deposited on 2018-07-18, released 2019-07-10
The last revision was dated 2020-07-29, with a file datestamp of 2020-07-24.
Experiment type: EM
Resolution: 3.9 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: BRISC complex subunit Abraxas 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ABRAXAS2, ABRO1, FAM175B, KIAA0157
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Lys-63-specific deubiquitinase BRCC36
    Species: Homo sapiens [TaxId:9606]
    Gene: BRCC3, BRCC36, C6.1A, CXorf53
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: BRISC and BRCA1-A complex member 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BABAM2, BRCC45, BRE
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: BRISC and BRCA1-A complex member 1
    Species: Homo sapiens [TaxId:9606]
    Gene: BABAM1, C19orf62, MERIT40, NBA1, HSPC142
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Serine hydroxymethyltransferase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: SHMT2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P34897
      • cloning artifact (287)
  • Chain 'F':
    Compound: BRISC complex subunit Abraxas 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ABRAXAS2, ABRO1, FAM175B, KIAA0157
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Lys-63-specific deubiquitinase BRCC36
    Species: Homo sapiens [TaxId:9606]
    Gene: BRCC3, BRCC36, C6.1A, CXorf53
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: BRISC and BRCA1-A complex member 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BABAM2, BRCC45, BRE
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: BRISC and BRCA1-A complex member 1
    Species: Homo sapiens [TaxId:9606]
    Gene: BABAM1, C19orf62, MERIT40, NBA1, HSPC142
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: Serine hydroxymethyltransferase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: SHMT2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P34897
      • cloning artifact (287)
  • Heterogens: ZN, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6h3cA (A:)
mhhhhhhvdenlyfqgggrmaasisgytfsavcfhsansnadhegfllgevrqeetfsis
dsqisnteflqvieihnhqpcsklfsfydyaskvneesldrilkdrrkkvigwyrfrrnt
qqqmsyreqvlhkqltrilgvpdlvfllfsfistannsthaleyvlfrpnrrynqrisla
ipnlgntsqqeykvssvpntsqsyakvikehgtdffdkdgvmkdiraiyqvynalqekvq
avcadvekservvescqaevnklrrqitqrknekeqerrlqqavlsrqmpsesldpafsp
rmpssgfaaegrstlgdaeasdppppysdfhpnnqestlshsrmersvfmprpqavgssn
yastsaglkypgsgadlpppqraagdsgedsddsdyenlidptepsnseyshskdsrpma
hpdedprntqtsqi

    Sequence, based on observed residues (ATOM records):
    >6h3cA (A:)
maasisgytfsavcfhsansnadhegfllgevrqeetfsisdsqisnteflqvieihnhq
pcsklfsfydyaskvneesldrilkdrrkkvigwyrfrrntqqqmsyreqvlhkqltril
gvpdlvfllfsfistannsthaleyvlfrpnrrynqrislaipnlgntsqqeykvssvpn
tsqsyakvikehgtdffdkdgvmkdiraiyqvynalqekvqavcadvekservvescqae
vnklrrqitqrknek

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6h3cB (B:)
mhhhhhhvdenlyfqgggrmavqvvqavqavhlesdaflvclnhalstekeevmglcige
lnddtrsdskfaytgtemrtvaekvdavrivhihsviilrrsdkrkdrveispeqlsaas
teaerlaeltgrpmrvvgwyhshphitvwpshvdvrtqamyqmmdqgfvglifscfiedk
ntktgrvlytcfqsiqaqksseslhgprdfwsssqhisiegqkeeeryerieipihivph
vtigkvclesavelpkilcqeeqdayrrihslthldsvtkihngsvftknlcsqmsavsg
pllqwledrleqnqqhlqelqqekeelmqelssle

    Sequence, based on observed residues (ATOM records):
    >6h3cB (B:)
avqavhlesdaflvclnhalstekeevmglcigelnddtvrivhihsviilrrsdkrkdr
veispeqlsaasteaerlaeltgrpmrvvgwyhshphitvwpshvdvrtqamyqmmdqgf
vglifscfiedkntktgrvlytcfqsiqaqyerieipihivphvtigkvclesavelpki
lcqeeqdayrrihslthldsvtkihngsvftknlcsqmsavsgpllqwledrleqnqqhl
qelqqekeelmqelssle

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6h3cC (C:)
mhhhhhhvdenlyfqgggrmspevalnrispmlspfissvvrngkvgldatnclritdlk
sgctsltpgpncdrfklhipyagetlkwdiifnaqypelppdfifgedaeflpdpsalqn
laswnpsnpeclllvvkelvqqyhqfqcsrlressrlmfeyqtlleepqygenmeiyagk
knnwtgefsarfllklpvdfsniptyllkdvnedpgedvallsvsfedteatqvypklyl
spriehalggssalhipafpgggclidyvpqvchlltnkvqyviqgyhkrreyiaaflsh
fgtgvveydaegftkltlllmwkdfcflvhidlplffprdqptltfqsvyhftnsgqlys
qaqknypysprwdgnemakrakayfktfvpqfqeaafangkl

    Sequence, based on observed residues (ATOM records):
    >6h3cC (C:)
mspevalnrispmlspfissvvrngkvgldatnclritdlksgctsltpgpncdrfklhi
pyagetlkwdiifnaqypelppdfifgedaeflpdpsalqnlaswnpsnpeclllvvkel
vqqyhqfqcsrlressrlmfeyqtlleepqygenmeiyagkknnwtgefsarfllklpvd
fsniptyllkdvnedpgedvallsvsfedteatqvypklylspriehalggssalhipaf
pgggclidyvpqvchlltnkvqyviqgyhkrreyiaaflshfgtgvveydaegftkltll
lmwkdfcflvhidlplffprdqptltfqsvyhftnsgqlysqaqknypysprwdgnemak
rakayfktfvpqfqeaafangkl

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6h3cD (D:)
maswshpqfekvdenlyfqgggrmevaepsspteeeeeeeehsaeprprtrsnpegaedr
avgaqasvgsrsegegeaasaddgslntsgagpkswqvpppapevqirtprvncpekvii
cldlseemslpklesfngsktnalnvsqkmiemfvrtkhkidkshefalvvvnddtawls
gltsdprelcsclydletascstfnleglfsliqqktelpvtenvqtipppyvvrtilvy
srppcqpqfsltepmkkmfqcpyfffdvvyihngteekeeemswkdmfafmgsldtkgts
ykyevalagpalelhncmakllahplqrpcqshasyslleeedeaieveatv

    Sequence, based on observed residues (ATOM records):
    >6h3cD (D:)
evqirtprvncpekviicldlseemslpklesfngsktnalnvsqkmiemfvrtkhkidk
shefalvvvnddtawlsgltsdprelcsclydletascstfnleglfsliqqktelpvte
nvqtipppyvvrtilvysrppcqpqfsltepmkkmfqcpyfffdvvyihngteekeeems
wkdmfafmgsldtkgtsykyevalagpalelhncmakllahplqrpcqshasyslle

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6h3cE (E:)
mgsshhhhhhssglvprgsgqlvrmairaqhsnaaqtqtgeanrgwtgqeslsdsdpemw
ellqrekdrqcrgleliasenfcsraalealgsclnnkysegypgkryyggaevvdeiel
lcqrraleafdldpaqwgvnvqpysgspanlavytallqphdrimgldlpdgghlthgym
sdvkrisatsiffesmpyklnpktglidynqlaltarlfrprliiagtsayarlidyarm
revcdevkahlladmahisglvaakvipspfkhadivtttthktlrgtrsglifyrkgvk
avdpktgreipytfedrinfavfpslqggphnhaiaavavalkqactpmfreyslqvlkn
aramadallergyslvsggtdnhlvlvdlrpkgldgaraervlelvsitankntcpgdrs
aitpgglrlgapaltsrqfreddfrrvvdfidegvniglevksktaklqdfksfllkdse
tsqrlanlrqrveqfarafpmpgfdeh

    Sequence, based on observed residues (ATOM records):
    >6h3cE (E:)
wtgqeslsdsdpemwellqrekdrqcrgleliasenfcsraalealgsclnnkysegypg
kryyggaevvdeiellcqrraleafdldpaqwgvnvqpysgspanlavytallqphdrim
gldlsiffesmpyklnpktglidynqlaltarlfrprliiagtsayarlidyarmrevcd
evkahlladmahisglvaakvipspfkhadivtttthktlrgtrsglifyrkgvkavdpk
tgreipytfedrinfavfpslqggphnhaiaavavalkqactpmfreyslqvlknarama
dallergyslvsggtdnhlvlvdlrpkgldgaraervlelvsitankntcpgdrsaitpg
glrlgapaltsrqfreddfrrvvdfidegvniglevksktaklqdfksfllkdsetsqrl
anlrqrveqfarafpmpgfd

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6h3cF (F:)
mhhhhhhvdenlyfqgggrmaasisgytfsavcfhsansnadhegfllgevrqeetfsis
dsqisnteflqvieihnhqpcsklfsfydyaskvneesldrilkdrrkkvigwyrfrrnt
qqqmsyreqvlhkqltrilgvpdlvfllfsfistannsthaleyvlfrpnrrynqrisla
ipnlgntsqqeykvssvpntsqsyakvikehgtdffdkdgvmkdiraiyqvynalqekvq
avcadvekservvescqaevnklrrqitqrknekeqerrlqqavlsrqmpsesldpafsp
rmpssgfaaegrstlgdaeasdppppysdfhpnnqestlshsrmersvfmprpqavgssn
yastsaglkypgsgadlpppqraagdsgedsddsdyenlidptepsnseyshskdsrpma
hpdedprntqtsqi

    Sequence, based on observed residues (ATOM records):
    >6h3cF (F:)
maasisgytfsavcfhsansnadhegfllgevrqeetfsisdsqisnteflqvieihnhq
pcsklfsfydyaskvneesldrilkdrrkkvigwyrfrrntqqqmsyreqvlhkqltril
gvpdlvfllfsfistannsthaleyvlfrpnrrynqrislaipnlgntsqqeykvssvpn
tsqsyakvikehgtdffdkdgvmkdiraiyqvynalqekvqavcadvekservvescqae
vnklrrqitqrknek

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6h3cG (G:)
mhhhhhhvdenlyfqgggrmavqvvqavqavhlesdaflvclnhalstekeevmglcige
lnddtrsdskfaytgtemrtvaekvdavrivhihsviilrrsdkrkdrveispeqlsaas
teaerlaeltgrpmrvvgwyhshphitvwpshvdvrtqamyqmmdqgfvglifscfiedk
ntktgrvlytcfqsiqaqksseslhgprdfwsssqhisiegqkeeeryerieipihivph
vtigkvclesavelpkilcqeeqdayrrihslthldsvtkihngsvftknlcsqmsavsg
pllqwledrleqnqqhlqelqqekeelmqelssle

    Sequence, based on observed residues (ATOM records):
    >6h3cG (G:)
avqavhlesdaflvclnhalstekeevmglcigelnddtvrivhihsviilrrsdkrkdr
veispeqlsaasteaerlaeltgrpmrvvgwyhshphitvwpshvdvrtqamyqmmdqgf
vglifscfiedkntktgrvlytcfqsiqaqyerieipihivphvtigkvclesavelpki
lcqeeqdayrrihslthldsvtkihngsvftknlcsqmsavsgpllqwledrleqnqqhl
qelqqekeelmqelssle

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6h3cH (H:)
mhhhhhhvdenlyfqgggrmspevalnrispmlspfissvvrngkvgldatnclritdlk
sgctsltpgpncdrfklhipyagetlkwdiifnaqypelppdfifgedaeflpdpsalqn
laswnpsnpeclllvvkelvqqyhqfqcsrlressrlmfeyqtlleepqygenmeiyagk
knnwtgefsarfllklpvdfsniptyllkdvnedpgedvallsvsfedteatqvypklyl
spriehalggssalhipafpgggclidyvpqvchlltnkvqyviqgyhkrreyiaaflsh
fgtgvveydaegftkltlllmwkdfcflvhidlplffprdqptltfqsvyhftnsgqlys
qaqknypysprwdgnemakrakayfktfvpqfqeaafangkl

    Sequence, based on observed residues (ATOM records):
    >6h3cH (H:)
mspevalnrispmlspfissvvrngkvgldatnclritdlksgctsltpgpncdrfklhi
pyagetlkwdiifnaqypelppdfifgedaeflpdpsalqnlaswnpsnpeclllvvkel
vqqyhqfqcsrlressrlmfeyqtlleepqygenmeiyagkknnwtgefsarfllklpvd
fsniptyllkdvnedpgedvallsvsfedteatqvypklylspriehalggssalhipaf
pgggclidyvpqvchlltnkvqyviqgyhkrreyiaaflshfgtgvveydaegftkltll
lmwkdfcflvhidlplffprdqptltfqsvyhftnsgqlysqaqknypysprwdgnemak
rakayfktfvpqfqeaafangkl

  • Chain 'I':
    Sequence, based on SEQRES records:
    >6h3cI (I:)
maswshpqfekvdenlyfqgggrmevaepsspteeeeeeeehsaeprprtrsnpegaedr
avgaqasvgsrsegegeaasaddgslntsgagpkswqvpppapevqirtprvncpekvii
cldlseemslpklesfngsktnalnvsqkmiemfvrtkhkidkshefalvvvnddtawls
gltsdprelcsclydletascstfnleglfsliqqktelpvtenvqtipppyvvrtilvy
srppcqpqfsltepmkkmfqcpyfffdvvyihngteekeeemswkdmfafmgsldtkgts
ykyevalagpalelhncmakllahplqrpcqshasyslleeedeaieveatv

    Sequence, based on observed residues (ATOM records):
    >6h3cI (I:)
evqirtprvncpekviicldlseemslpklesfngsktnalnvsqkmiemfvrtkhkidk
shefalvvvnddtawlsgltsdprelcsclydletascstfnleglfsliqqktelpvte
nvqtipppyvvrtilvysrppcqpqfsltepmkkmfqcpyfffdvvyihngteekeeems
wkdmfafmgsldtkgtsykyevalagpalelhncmakllahplqrpcqshasyslle

  • Chain 'J':
    Sequence, based on SEQRES records:
    >6h3cJ (J:)
mgsshhhhhhssglvprgsgqlvrmairaqhsnaaqtqtgeanrgwtgqeslsdsdpemw
ellqrekdrqcrgleliasenfcsraalealgsclnnkysegypgkryyggaevvdeiel
lcqrraleafdldpaqwgvnvqpysgspanlavytallqphdrimgldlpdgghlthgym
sdvkrisatsiffesmpyklnpktglidynqlaltarlfrprliiagtsayarlidyarm
revcdevkahlladmahisglvaakvipspfkhadivtttthktlrgtrsglifyrkgvk
avdpktgreipytfedrinfavfpslqggphnhaiaavavalkqactpmfreyslqvlkn
aramadallergyslvsggtdnhlvlvdlrpkgldgaraervlelvsitankntcpgdrs
aitpgglrlgapaltsrqfreddfrrvvdfidegvniglevksktaklqdfksfllkdse
tsqrlanlrqrveqfarafpmpgfdeh

    Sequence, based on observed residues (ATOM records):
    >6h3cJ (J:)
wtgqeslsdsdpemwellqrekdrqcrgleliasenfcsraalealgsclnnkysegypg
kryyggaevvdeiellcqrraleafdldpaqwgvnvqpysgspanlavytallqphdrim
gldlsiffesmpyklnpktglidynqlaltarlfrprliiagtsayarlidyarmrevcd
evkahlladmahisglvaakvipspfkhadivtttthktlrgtrsglifyrkgvkavdpk
tgreipytfedrinfavfpslqggphnhaiaavavalkqactpmfreyslqvlknarama
dallergyslvsggtdnhlvlvdlrpkgldgaraervlelvsitankntcpgdrsaitpg
glrlgapaltsrqfreddfrrvvdfidegvniglevksktaklqdfksfllkdsetsqrl
anlrqrveqfarafpmpgfd