PDB entry 6h25

View 6h25 on RCSB PDB site
Description: human nuclear rna exosome exo-10-mpp6 complex
Deposited on 2018-07-13, released 2018-08-15
The last revision was dated 2019-02-20, with a file datestamp of 2019-02-15.
Experiment type: EM
Resolution: 3.8 Å
R-factor: N/A
AEROSPACI score: 0.07 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: exosome complex component rrp45
    Species: Homo sapiens [TaxId:9606]
    Gene: EXOSC9, PMSCL1
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Exosome complex component RRP41
    Species: Homo sapiens [TaxId:9606]
    Gene: EXOSC4, RRP41, SKI6
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Exosome complex component RRP43
    Species: Homo sapiens [TaxId:9606]
    Gene: EXOSC8, OIP2, RRP43
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Exosome complex component RRP46
    Species: Homo sapiens [TaxId:9606]
    Gene: EXOSC5, CML28, RRP46
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Exosome complex component RRP42
    Species: Homo sapiens [TaxId:9606]
    Gene: EXOSC7, KIAA0116, RRP42
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Exosome complex component MTR3
    Species: Homo sapiens [TaxId:9606]
    Gene: EXOSC6, MTR3
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Exosome complex component RRP40
    Species: Homo sapiens [TaxId:9606]
    Gene: EXOSC3, RRP40, CGI-102
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Exosome complex component RRP4
    Species: Homo sapiens [TaxId:9606]
    Gene: EXOSC2, RRP4
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: Exosome complex component CSL4
    Species: Homo sapiens [TaxId:9606]
    Gene: EXOSC1, CSL4, CGI-108
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: exosome complex exonuclease rrp44
    Species: Homo sapiens [TaxId:9606]
    Gene: DIS3, KIAA1008, RRP44
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y2L1 (4-End)
      • engineered mutation (149)
      • engineered mutation (490)
  • Chain 'K':
    Compound: M-phase phosphoprotein 6
    Species: Homo sapiens [TaxId:9606]
    Gene: MPHOSPH6, MPP6
    Database cross-references and differences (RAF-indexed):
  • Chain 'R':
    Compound: U44 ssRNA
    Species: synthetic construct, synthetic [TaxId:32630]

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6h25A (A:)
    gpdsmketplsncerrfllraieekkrldgrqtydyrnirisfgtdygccivelgktrvl
    gqvscelvspklnrategilffnlelsqmaapafepgrqsdllvklnrlmerclrnskci
    dteslcvvagekvwqirvdlhllnhdgniidaasiaaivalchfrrpdvsvqgdevtlyt
    peerdpvplsihhmpicvsfaffqqgtyllvdpnereervmdgllviamnkhreictiqs
    sggimllkdqvlrcskiagvkvaeitelilkalendqkvrkeggkfgfaesianqritaf
    kmekapidtsdveekaeeiiaeaeppsevvstpvlwtpgtaqigegvenswgdledseke
    ddegggdqaiildgikmdtgvevsdigsqdapiilsdseeeemiilepdknpkkirtqtt
    sakqekapskkpvkrrkkkraan
    

    Sequence, based on observed residues (ATOM records):
    >6h25A (A:)
    ketplsncerrfllraieekkrldgrqtydyrnirisfgtdygccivelgktrvlgqvsc
    elvspklnrategilffnlelsqmaapafepgrqsdllvklnrlmerclrnskcidtesl
    cvvagekvwqirvdlhllnhdgniidaasiaaivalchfrrpdvsvqgdevtlytpeerd
    pvplsihhmpicvsfaffqqgtyllvdpnereervmdgllviamnkhreictiqssggim
    llkdqvlrcskiagvkvaeitelilkalendqkvrkeggkfgfaesi
    

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6h25B (B:)
    gpdsmaglellsdqgyrvdgrragelrkiqarmgvfaqadgsayieqgntkalavvygph
    eirgsraralpdralvncqyssatfstgerkrrphgdrkscemglqlrqtfeaailtqlh
    prsqidiyvqvlqadggtyaacvnaatlavldagipmrdfvcacsagfvdgtaladlshv
    eeaaggpqlalallpasgqiallemdarlhedhlervleaaaqaardvhtlldrvvrqhv
    reasillgd
    

    Sequence, based on observed residues (ATOM records):
    >6h25B (B:)
    llsdqgyrvdgrragelrkiqarmgvfaqadgsayieqgntkalavvygpheirgsrara
    lpdralvncqyssatfstgerkrrphgdrkscemglqlrqtfeaailtqlhprsqidiyv
    qvlqadggtyaacvnaatlavldagipmrdfvcacsagfvdgtaladlshveeaaggpql
    alallpasgqiallemdarlhedhlervleaaaqaardvhtlldrvvrqhvreasillg
    

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6h25C (C:)
    rsmaagfktvepleyyrrflkencrpdgrelgefrtttvnigsistadgsalvklgnttv
    icgvkaefaapstdapdkgyvvpnvdlpplcssrfrsgppgeeaqvasqfiadviensqi
    iqkedlcispgklvwvlycdlicldydgnildactfallaalknvqlpevtineetalae
    vnlkkksylnirthpvatsfavfddtllivdptgeeehlatgtltivmdeegklcclhkp
    ggsgltgaklqdcmsravtrhkevkklmdeviksmkpk
    

    Sequence, based on observed residues (ATOM records):
    >6h25C (C:)
    eyyrrflkencrpdgrelgefrtttvnigsistadgsalvklgnttvicgvkaefaapst
    dapdkgyvvpnvdlpplcssrfrsgppgeeaqvasqfiadviensqiiqkedlcispgkl
    vwvlycdlicldydgnildactfallaalknvqlpevtineetalaevnlkkksylnirt
    hpvatsfavfddtllivdptgeeehlatgtltivmdeegklcclhkpggsgltgaklqdc
    msravtrhkevkklmdeviksmkp
    

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6h25D (D:)
    rsmeeethtdakiraengtgssprgpgcslrhfaceqnllsrpdgsasflqgdtsvlagv
    ygpaevkvskeifnkatlevilrpkiglpgvaeksrerlirntceavvlgtlhprtsitv
    vlqvvsdagsllacclnaacmalvdagvpmralfcgvacaldsdgtlvldptskqekear
    avltfaldsverkllmsstkglysdtelqqclaaaqaasqhvfrfyreslqrrysks
    

    Sequence, based on observed residues (ATOM records):
    >6h25D (D:)
    gcslrhfaceqnllsrpdgsasflqgdtsvlagvygpaevkvskeifnkatlevilrpki
    glpgvaeksrerlirntceavvlgtlhprtsitvvlqvvsdagsllacclnaacmalvda
    gvpmralfcgvacaldsdgtlvldptskqekearavltfaldsverkllmsstkglysdt
    elqqclaaaqaasqhvfrfyreslqrrysk
    

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6h25E (E:)
    gpdsmasvtlseaekvyivhgvqedlrvdgrgcedyrcvevetdvvsntsgsarvklght
    dilvgvkaemgtpklekpnegyleffvdcsasatpefegrggddlgteiantlyrifnnk
    ssvdlktlcisprehcwvlyvdvlllecggnlfdaisiavkaalfntriprvrvledeeg
    skdielsddpydcirlsvenvpcivtlckigyrhvvdatlqeeacslasllvsvtskgvv
    tcmrkvgkgsldpesifemmetgkrvgkvlhaslqsvvhkeeslgpkrqkvgflg
    

    Sequence, based on observed residues (ATOM records):
    >6h25E (E:)
    vtlseaekvyivhgvqedlrvdgrgcedyrcvevetdvvsntsgsarvklghtdilvgvk
    aemgtpklekpnegyleffvdcsasatpefegrggddlgteiantlyrifnnkssvdlkt
    lcisprehcwvlyvdvlllecggnlfdaisiavkaalfntriprvrvledeegskdiels
    ddpydcirlsvenvpcivtlckigyrhvvdatlqeeacslasllvsvtskgvvtcmrkvg
    kgsldpesifemmetgkrvgkvlhaslqsvvhkeeslgpkrqkvgfl
    

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6h25F (F:)
    gpdsmpgdhrrirgpeesqppqlyaadeeeapgtrdptrlrpvyaragllsqakgsayle
    aggtkvlcavsgprqaeggergggpagaggeapaalrgrllcdfrrapfagrrrrappgg
    ceerelalalqealepavrlgrypraqlevsallledggsalaaaltaaalaladagvem
    ydlvvgcglslapgpaptwlldptrleeeraaagltvalmpvlnqvagllgsgeggltes
    waeavrlglegcqrlypvlqqslvraarrrgaaaqp
    

    Sequence, based on observed residues (ATOM records):
    >6h25F (F:)
    dhrrirgpeesqppqlyaadeeeapgtrdptrlrpvyaragllsqakgsayleaggtkvl
    cavsgprqalrgrllcdfrrapfagrrrrappggceerelalalqealepavrlgrypra
    qlevsallledggsalaaaltaaalaladagvemydlvvgcglslapgpaptwlldptrl
    eeeraaagltvalmpvlnqvagllgsgegglteswaeavrlglegcqrlypvlqqslvra
    arrr
    

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6h25G (G:)
    gsgsgsgsgsgsgsgsgsmaepasvaaeslagsraraartvlgqvvlpgeelllpeqeda
    egpggaverplslnaracsrvrvvcgpglrrcgdrllvtkcgrlrhkepgsgsgggvywv
    dsqqkryvpvkgdhvigivtaksgdifkvdvggsepaslsylsfegatkrnrpnvqvgdl
    iygqfvvankdmepemvcidscgrangmgvigqdgllfkvtlglirkllapdceiiqevg
    klypleivfgmngriwvkaktiqqtlilanileacehmtsdqrkqifsrlaes
    

    Sequence, based on observed residues (ATOM records):
    >6h25G (G:)
    araartvlgqvvlpgeelllpervrvvcgpglrrcgdrllvtkcgrlrhkevywvdsqqk
    ryvpvkgdhvigivtaksgdifkvdvggsepaslsylsfegatkrnrpnvqvgdliygqf
    vvankdmepemvcidscgrangmgvigqdgllfkvtlglirkllapdceiiqevgklypl
    eivfgmngriwvkaktiqqtlilanileac
    

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6h25H (H:)
    gpdsmamemrlpvarkplserlgrdtkkhlvvpgdtittdtgfmrghgtymgeekliasv
    agsvervnklicvkalktryigevgdivvgritevqqkrwkvetnsrldsvlllssmnlp
    ggelrrrsaedelamrgflqegdlisaevqavfsdgavslhtrslkygklgqgvlvqvsp
    slvkrqkthfhdlpcgasvilgnngfiwiyptpehkeeeaggfianlepvsladrevisr
    lrnciislvtqrmmlydtsilycyeaslphqikdilkpeimeeivmetrqrlleqeg
    

    Sequence, based on observed residues (ATOM records):
    >6h25H (H:)
    mamemrlpvarkplsgrdtkkhlvvpgdtittdtgfmrghgtymgeekliasvagsverv
    nklicvkalktryigevgdivvgritevqqkrwkvetnsrldsvlllssmnlaedelamr
    gflqegdlisaevqavfsdgavslhtrslkygklgqgvlvqvspslvkrqkthfhdlpcg
    asvilgnngfiwiyptpehkfianlepvsladrevisrlrnciislvtqrmmlydtsily
    cyeaslphqikdilkpeimeeivmetrqrlleqeg
    

  • Chain 'I':
    Sequence, based on SEQRES records:
    >6h25I (I:)
    gpdsmappvrycipgerlcnleegspgsgtytrhgyifsslagclmkssengalpvvsvv
    retesqllpdvgaivtckvssinsrfakvhilyvgsmplknsfrgtirkedvratekdkv
    eiyksfrpgdivlakvislgdaqsnyllttaenelgvvvahsesgiqmvpiswcemqcpk
    thtkefrkvarvqpeflqt
    

    Sequence, based on observed residues (ATOM records):
    >6h25I (I:)
    vrycipgerlcnleegspgsgtytrhgyifsslagclmklpvvsvvrete
    

  • Chain 'J':
    Sequence, based on SEQRES records:
    >6h25J (J:)
    gpdsmlksktflkktraggvmkivrehylrddigcgapgcaacggahegpalepqpqdpa
    ssvcpqphyllpdtnvllhqidvledpairnvivlqtvlqevrnrsapvykrirdvtnnq
    ekhfytftnehhretyveqeqgenandrnnrairvaakwynehlkkmsadnqlqvifitn
    drrnkekaieegipaftceeyvksltanpelidrlaclseegneiesgkiifsehlplsk
    lqqgiksgtylqgtfrasrenyleatvwihgdneenkeiilqglkhlnravhedivavel
    lpksqwvapssvvlhdegqneedvekeeetermlktavsekmlkptgrvvgiikrnwrpy
    cgmlsksdikesrrhlftpadkripririetrqastlegrriivaidgwprnsrypnghf
    vrnlgdvgeketetevlllehdvphqpfsqavlsflpkmpwsitekdmknredlrhlcic
    svdppgctdindalhcrelengnlevgvhiadvshfirpgnaldqesarrgttvylcekr
    idmvpellssnlcslkcdvdrlafsciwemnhnaeilktkftksvinskasltyaeaqlr
    idsanmnddittslrglnklakilkkrriekgaltlsspevrfhmdsethdpidlqtkel
    retnsmveefmllanisvakkiheefsehallrkhpapppsnyeilvkaarsrnleiktd
    takslaesldqaesptfpylntllrilatrcmmqavyfcsgmdndfhhyglaspiythft
    spirryadvivhrllavaigadctypeltdkhkladicknlnfrhkmaqyaqrasvafht
    qlffkskgivseeayilfvrknaivvlipkyglegtvffeekdkpnpqliyddeipslki
    edtvfhvfdkvkvkimldssnlqhqkirmslvepqipgisiptdtsnmdlngpkkkkmkl
    gk
    

    Sequence, based on observed residues (ATOM records):
    >6h25J (J:)
    mlksktflkktraggvmkivrehylrddigcgapgcaacggahegpalepqpqdpassvc
    pqphyllpdtnvllhqidvledpairnvivlqtvlqevrnrsapvykrirdvtnnqekhf
    ytftnehhretyveqeqgenandrnnrairvaakwynehlkkmsadnqlqvifitndrrn
    kekaieegipaftceeyvksltanpelidrfsehlplsklqqgiksgtylqgtfrasren
    yleatvwihkeiilqglkhlnravhedivavellpksqwptgrvvgiikrnwrpycgmls
    ksdikesrrhlftpadkripririetrqastlegrriivaidgwprnsrypnghfvrnlg
    dvgeketetevlllehdvphqpfsqavlsflpkmpwsitekdmknredlrhlcicsvdpp
    gctdindalhcrelengnlevgvhiadvshfirpgnaldqesarrgttvylcekridmvp
    ellssnlcslkcdvdrlafsciwemnhnaeilktkftksvinskasltyaeaqlridsan
    mnddittslrglnklakilkkrriekgaltlsspevrfhmdsethdpidlqtkelretns
    mveefmllanisvakkiheefsehallrkhpapppsnyeilvkaarsrnleiktdtaksl
    aesldqaesptfpylntllrilatrcmmqavyfcsgmdndfhhyglaspiythftspirr
    yadvivhrllavaigadctypeltdkhkladicknlnfrhkmaqyaqrasvafhtqlffk
    skgivseeayilfvrknaivvlipkyglegtvffeekdkpnpqliyddeipslkiedtvf
    hvfdkvkvkimldssnlqhqkirmslve
    

  • Chain 'K':
    Sequence, based on SEQRES records:
    >6h25K (K:)
    gpdsasmaaerktklsknllrmkfmqrgldsetkkqleeeekkiiseehwyldlpelkek
    esfiieeqsfllcedllygrmsfrgfnpeveklmlqmnakhkaeevedetveldvsdeem
    arryetlvgtigkkfarkrdhanyeedengditpikakkmflkpqd
    

    Sequence, based on observed residues (ATOM records):
    >6h25K (K:)
    eeqsfllcedllygrmsfrgfnpeveklmlqmnakhk
    

  • Chain 'R':
    No sequence available.