PDB entry 6h23

View 6h23 on RCSB PDB site
Description: Crystal structure of the hClpP Y118A mutant with an activating small molecule
Class: hydrolase
Keywords: protease, small molecule, 14mer, serine protease, oligomerization, HYDROLASE
Deposited on 2018-07-13, released 2018-08-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-04-03, with a file datestamp of 2019-03-29.
Experiment type: XRAY
Resolution: 3.09 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16740
      • engineered mutation (61)
    Domains in SCOPe 2.08: d6h23a_
  • Chain 'B':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16740
      • engineered mutation (61)
    Domains in SCOPe 2.08: d6h23b_
  • Chain 'C':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16740
      • engineered mutation (61)
    Domains in SCOPe 2.08: d6h23c_
  • Chain 'D':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16740
      • engineered mutation (61)
    Domains in SCOPe 2.08: d6h23d_
  • Chain 'E':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16740
      • engineered mutation (61)
    Domains in SCOPe 2.08: d6h23e_
  • Chain 'F':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16740
      • engineered mutation (61)
    Domains in SCOPe 2.08: d6h23f_
  • Chain 'G':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16740
      • engineered mutation (61)
    Domains in SCOPe 2.08: d6h23g_
  • Chain 'H':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16740
      • engineered mutation (61)
    Domains in SCOPe 2.08: d6h23h_
  • Chain 'I':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16740
      • engineered mutation (61)
    Domains in SCOPe 2.08: d6h23i_
  • Chain 'J':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16740
      • engineered mutation (61)
    Domains in SCOPe 2.08: d6h23j_
  • Chain 'K':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16740
      • engineered mutation (61)
    Domains in SCOPe 2.08: d6h23k_
  • Chain 'L':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16740
      • engineered mutation (61)
    Domains in SCOPe 2.08: d6h23l_
  • Chain 'M':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16740
      • engineered mutation (61)
    Domains in SCOPe 2.08: d6h23m_
  • Chain 'N':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16740
      • engineered mutation (61)
    Domains in SCOPe 2.08: d6h23n_
  • Heterogens: FJT, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6h23A (A:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
mainspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpastwshpqfek

    Sequence, based on observed residues (ATOM records): (download) 
    >6h23A (A:)
diysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmainspggvvtaglaiy
dtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpiaiqaeeimklkk
qlyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6h23B (B:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
mainspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpastwshpqfek

    Sequence, based on observed residues (ATOM records): (download) 
    >6h23B (B:)
diysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmainspggvvtaglaiy
dtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpiaiqaeeimklkk
qlyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhpp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6h23C (C:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
mainspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpastwshpqfek

    Sequence, based on observed residues (ATOM records): (download) 
    >6h23C (C:)
ydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmainspggvvtaglai
ydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpiaiqaeeimklk
kqlyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6h23D (D:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
mainspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpastwshpqfek

    Sequence, based on observed residues (ATOM records): (download) 
    >6h23D (D:)
ydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmainspggvvtaglai
ydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpiqaeeimklkkq
lyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhp

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6h23E (E:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
mainspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpastwshpqfek

    Sequence, based on observed residues (ATOM records): (download) 
    >6h23E (E:)
ydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmainspggvvtaglai
ydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpiaiqaeeimklk
kqlyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhp

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6h23F (F:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
mainspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpastwshpqfek

    Sequence, based on observed residues (ATOM records): (download) 
    >6h23F (F:)
diysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmainspggvvtaglaiy
dtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpdiaiqaeeimklk
kqlyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhp

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6h23G (G:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
mainspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpastwshpqfek

    Sequence, based on observed residues (ATOM records): (download) 
    >6h23G (G:)
ydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmainspggvvtaglai
ydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpsdiaiqaeeimk
lkkqlyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhpp

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6h23H (H:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
mainspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpastwshpqfek

    Sequence, based on observed residues (ATOM records): (download) 
    >6h23H (H:)
ydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmainspggvvtaglai
ydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpdiaiqaeeimkl
kkqlyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhp

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >6h23I (I:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
mainspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpastwshpqfek

    Sequence, based on observed residues (ATOM records): (download) 
    >6h23I (I:)
ydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmainspggvvtaglai
ydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpdiaiqaeeimkl
kkqlyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhp

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >6h23J (J:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
mainspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpastwshpqfek

    Sequence, based on observed residues (ATOM records): (download) 
    >6h23J (J:)
ydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmainspggvvtaglai
ydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpiaiqaeeimklk
kqlyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhp

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >6h23K (K:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
mainspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpastwshpqfek

    Sequence, based on observed residues (ATOM records): (download) 
    >6h23K (K:)
ydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmainspggvvtaglai
ydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpiaiqaeeimklk
kqlyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhp

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6h23L (L:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
mainspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpastwshpqfek

    Sequence, based on observed residues (ATOM records): (download) 
    >6h23L (L:)
ydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmainspggvvtaglai
ydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpiaiqaeeimklk
kqlyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhp

  • Chain 'M':
    Sequence, based on SEQRES records: (download) 
    >6h23M (M:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
mainspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpastwshpqfek

    Sequence, based on observed residues (ATOM records): (download) 
    >6h23M (M:)
ydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmainspggvvtaglai
ydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpiaiqaeeimklk
kqlyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhp

  • Chain 'N':
    Sequence, based on SEQRES records: (download) 
    >6h23N (N:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
mainspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpastwshpqfek

    Sequence, based on observed residues (ATOM records): (download) 
    >6h23N (N:)
ydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmainspggvvtaglai
ydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpsiaiqaeeimkl
kkqlyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhpp