PDB entry 6h1a

View 6h1a on RCSB PDB site
Description: Crystal structure of VX surrogate NEMP inhibited recombinant human bile salt activated lipase
Class: hydrolase
Keywords: Lipase, alpha-beta hydrolase, tabun inhibition, HYDROLASE
Deposited on 2018-07-11, released 2019-03-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-03-27, with a file datestamp of 2019-03-22.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bile salt-activated lipase
    Species: Homo sapiens [TaxId:9606]
    Gene: CEL, BAL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19835 (15-546)
      • expression tag (13-14)
      • engineered mutation (199)
      • engineered mutation (311)
    Domains in SCOPe 2.08: d6h1aa1, d6h1aa2
  • Heterogens: SVX, ZN, ACT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6h1aA (A:)
hhhhhhhhenlyfqsklgavyteggfvegvnkklgllgdsvdifkgipfaaptkalenpq
phpgwqgtlkaknfkkrclqatitqdstygdedclylniwvpqgrkqvsrdlpvmiwiyg
gaflmgsghganflnnylydgeeiatrgnvivvtfnyrvgplgflstgdanlpgnyglrd
qhmaiawvkrniaafggdpdnitlfgexaggasvslqtlspynkglirraisqsgvalsp
wviqknplfwakkvaekvgcpvgdaarmaqclkvtdpraltlaykvplagleypmlhyvg
fvpvidgdfipddpinlyanaadidyiagtnnmdghifasidmpainkgnkkvteedfyk
lvseftitkglrgakttfdvyteswaqdpsqenkkktvvdfetdvlflvpteialaqhra
naksaktyaylfshpsrmpvypkwvgadhaddiqyvfgkpfatptgyrpqdrtvskamia
ywtnfaktgdpnmgdsavpthwepyttensgyleitkkmgsssmkrslrtnflrywtlty
lalptvt

    Sequence, based on observed residues (ATOM records): (download) 
    >6h1aA (A:)
qsklgavyteggfvegvnkklgllgdsvdifkgipfaaptkalenpqphpgwqgtlkakn
fkkrclqatitqdstygdedclylniwvpqgrkqvsrdlpvmiwiyggaflmgsghganf
lnnylydgeeiatrgnvivvtfnyrvgplgflstgdanlpgnyglrdqhmaiawvkrnia
afggdpdnitlfgexaggasvslqtlspynkglirraisqsgvalspwviqknplfwakk
vaekvgcpvgdaarmaqclkvtdpraltlaykvplagleypmlhyvgfvpvidgdfipdd
pinlyanaadidyiagtnnmdghifasidmpainkgnkkvteedfyklvseftitkglrg
akttfdvyteswaqdpsqenkkktvvdfetdvlflvpteialaqhranaksaktyaylfs
hpadhaddiqyvfgkpfatptgyrpqdrtvskamiaywtnfaktgdpnmgdsavpthwep
yttensgyleitkkmgsssmkrslrtnflrywtltylalptvt