SCOPe 2.08: Structural Classification of Proteins

PDB entry 6h0g

View 6h0g on RCSB PDB site
Description: structure of the ddb1-crbn-pomalidomide complex bound to znf692(zf4)
Deposited on 2018-07-09, released 2018-11-07
The last revision was dated 2019-04-17, with a file datestamp of 2019-04-12.
Experiment type: XRAY
Resolution: 4.25 Å
R-factor: N/A
AEROSPACI score: 0.04 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1,DDB1 (DNA damage binding protein 1),DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1
Species: Homo sapiens [TaxId:9606]
Gene: DDB1, XAP1
Database cross-references and differences (RAF-indexed):
- Uniprot Q16531 (20-End)
- PDB 6H0G
- Uniprot Q16531 (Start-855)
Chain 'B':
Compound: Protein cereblon
Species: Homo sapiens [TaxId:9606]
Gene: CRBN, AD-006
Database cross-references and differences (RAF-indexed):
- Uniprot Q96SW2 (Start-425)
Chain 'C':
Compound: Zinc finger protein 692
Species: Homo sapiens [TaxId:9606]
Gene: ZNF692
Database cross-references and differences (RAF-indexed):
- Uniprot Q9BU19 (1-30)
  - conflict (2-3)
Chain 'D':
Compound: DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1,DDB1 (DNA damage binding protein 1),DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1
Species: Homo sapiens [TaxId:9606]
Gene: DDB1, XAP1
Database cross-references and differences (RAF-indexed):
- Uniprot Q16531 (20-End)
- PDB 6H0G
- Uniprot Q16531 (Start-855)
Chain 'E':
Compound: Protein cereblon
Species: Homo sapiens [TaxId:9606]
Gene: CRBN, AD-006
Database cross-references and differences (RAF-indexed):
- Uniprot Q96SW2 (Start-425)
Chain 'F':
Compound: Zinc finger protein 692
Species: Homo sapiens [TaxId:9606]
Gene: ZNF692
Database cross-references and differences (RAF-indexed):
- Uniprot Q9BU19 (1-30)
  - conflict (2-3)
Heterogens: ZN, Y70

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

Chain 'A':
Sequence, based on SEQRES records:

>6h0gA (A:)
mhhhhhhvdeenlyfqgggrmsynyvvtaqkptavngcvtghftsaedlnlliakntrle
iyvvtaeglrpvkevgmygkiavmelfrpkgeskdllfiltakynacileykqsgesidi
itrahgnvqdrigrpsetgiigiidpecrmiglrlydglfkvipldrdnkelkafnirle
elhvidvkflygcqapticfvyqdpqgrhvktyevslrekefnkgpwkqenveaeasmvi
avpepfggaiiigqesityhngdkylaiappiikqstivchnrvdpngsryllgdmegrl
fmlllekeeqmdgtvtlkdlrvellgetsiaecltyldngvvfvgsrlgdsqlvklnvds
neqgsyvvametftnlgpivdmcvvdlerqgqgqlvtcsgafkegslriirngiggngns
geiqklhirtvplyesprkicyqevsqcfgvlssrievqdtsggttalrpsastqalsss
vsssklfssstaphetsfgeevevhnlliidqhtfevlhahqflqneyalslvscklgkd
pntyfivgtamvypeeaepkqgrivvfqysdgklqtvaekevkgavysmvefngkllasi
nstvrlyewttekelrtecnhynnimalylktkgdfilvgdlmrsvlllaykpmegnfee
iardfnpnwmsaveildddnflgaenafnlfvcqkdsaattdeerqhlqevglfhlgefv
nvfchgslvmqnlgetstptqgsvlfgtvngmiglvtslseswynllldmqnrlnkviks
vgkiehsfwrsfhterktepatgfidgdliesfldisrpkmqevvanlqyddgsgmkrea
taddlikvveeltrih

Sequence, based on observed residues (ATOM records):

>6h0gA (A:)
msynyvvtaqkptavngcvtghftsaedlnlliakntrleiyvvtaeglrpvkevgmygk
iavmelfrpkgeskdllfiltakynacileykqsgesidiitrahgnvqdrigrpsetgi
igiidpecrmiglrlydglfkvipldrdnkelkafnirleelhvidvkflygcqapticf
vyqdpqgrhvktyevslrekefnkgpwkqenveaeasmviavpepfggaiiigqesityh
ngdkylaiappiikqstivchnrvdpngsryllgdmegrlfmlllekeeqmdgtvtlkdl
rvellgetsiaecltyldngvvfvgsrlgdsqlvklnvdsneqgsyvvametftnlgpiv
dmcvvdlerqgqgqlvtcsgafkegslriirngklhirtvplyesprkicyqevsqcfgv
lssrievqdtsggttalrpsastqalsssvsssklfssstaphetsfgeevevhnlliid
qhtfevlhahqflqneyalslvscklgkdpntyfivgtamvypeeaepkqgrivvfqysd
gklqtvaekevkgavysmvefngkllasinstvrlyewttekelrtecnhynnimalylk
tkgdfilvgdlmrsvlllaykpmegnfeeiardfnpnwmsaveildddnflgaenafnlf
vcqkdsaattdeerqhlqevglfhlgefvnvfchgslvmqnlgetstptqgsvlfgtvng
miglvtslseswynllldmqnrlnkviksvgkiehsfwrsfhterktepatgfidgdlie
sfldisrpkmqevvanlqyddgsgmkreataddlikvveeltrih

Chain 'B':
Sequence, based on SEQRES records:

>6h0gB (B:)
mdwshpqfeksavdenlyfqgggrakkpniinfdtslptshtylgadmeefhgrtlhddd
scqvipvlpqvmmilipgqtlplqlfhpqevsmvrnliqkdrtfavlaysnvqereaqfg
ttaeiyayreeqdfgieivkvkaigrqrfkvlelrtqsdgiqqakvqilpecvlpstmsa
vqleslnkcqifpskpvsredqcsykwwqkyqkrkfhcanltswprwlyslydaetlmdr
ikkqlrewdenlkddslpsnpidfsyrvaaclpiddvlriqllkigsaiqrlrceldimn
kctslcckqcqeteittkneifslslcgpmaayvnphgyvhetltvykacnlnligrpst
ehswfpgyawtvaqckicashigwkftatkkdmspqkfwgltrsallptipdtedeispd
kvilcl

Sequence, based on observed residues (ATOM records):

>6h0gB (B:)
kkpniinfdtslptshtylgadmeefhgrtlhdddscqvipvlpqvmmilipgqtlplql
fhpqevsmvrnliqkdrtfavlaysnvqereaqfgttaeiyayreeqdfgieivkvkaig
rqrfkvlelrtqsdgiqqakvqilpecvlpstmsavqleslnkcqifpskpvsredqcsy
kwwqkyqkrkfhcanltswprwlyslydaetlmdrikkqlrewdenlkddslpsnpidfs
yrvaaclpiddvlriqllkigsaiqrlrceldimnkctslcckqcqeteittkneifsls
lcgpmaayvnphgyvhetltvykacnlnligrpstehswfpgyawtvaqckicashigwk
ftatkkdmspqkfwgltrsallptipdtedeispdkvilcl

Chain 'C':
Sequence, based on SEQRES records:
```
>6h0gC (C:)
gggrplqceicgftcrqkaslnwhqrkhaet
```
Sequence, based on observed residues (ATOM records):
```
>6h0gC (C:)
ggrplqceicgftcrqkaslnwhqrkhaet
```

Chain 'D':
Sequence, based on SEQRES records:

>6h0gD (D:)
mhhhhhhvdeenlyfqgggrmsynyvvtaqkptavngcvtghftsaedlnlliakntrle
iyvvtaeglrpvkevgmygkiavmelfrpkgeskdllfiltakynacileykqsgesidi
itrahgnvqdrigrpsetgiigiidpecrmiglrlydglfkvipldrdnkelkafnirle
elhvidvkflygcqapticfvyqdpqgrhvktyevslrekefnkgpwkqenveaeasmvi
avpepfggaiiigqesityhngdkylaiappiikqstivchnrvdpngsryllgdmegrl
fmlllekeeqmdgtvtlkdlrvellgetsiaecltyldngvvfvgsrlgdsqlvklnvds
neqgsyvvametftnlgpivdmcvvdlerqgqgqlvtcsgafkegslriirngiggngns
geiqklhirtvplyesprkicyqevsqcfgvlssrievqdtsggttalrpsastqalsss
vsssklfssstaphetsfgeevevhnlliidqhtfevlhahqflqneyalslvscklgkd
pntyfivgtamvypeeaepkqgrivvfqysdgklqtvaekevkgavysmvefngkllasi
nstvrlyewttekelrtecnhynnimalylktkgdfilvgdlmrsvlllaykpmegnfee
iardfnpnwmsaveildddnflgaenafnlfvcqkdsaattdeerqhlqevglfhlgefv
nvfchgslvmqnlgetstptqgsvlfgtvngmiglvtslseswynllldmqnrlnkviks
vgkiehsfwrsfhterktepatgfidgdliesfldisrpkmqevvanlqyddgsgmkrea
taddlikvveeltrih

Sequence, based on observed residues (ATOM records):

>6h0gD (D:)
msynyvvtaqkptavngcvtghftsaedlnlliakntrleiyvvtaeglrpvkevgmygk
iavmelfrpkgeskdllfiltakynacileykqsgesidiitrahgnvqdrigrpsetgi
igiidpecrmiglrlydglfkvipldrdnkelkafnirleelhvidvkflygcqapticf
vyqdpqgrhvktyevslrekefnkgpwkqenveaeasmviavpepfggaiiigqesityh
ngdkylaiappiikqstivchnrvdpngsryllgdmegrlfmlllekeeqmdgtvtlkdl
rvellgetsiaecltyldngvvfvgsrlgdsqlvklnvdsneqgsyvvametftnlgpiv
dmcvvdlerqgqgqlvtcsgafkegslriirngklhirtvplyesprkicyqevsqcfgv
lssrievqdtsggttalrpsastqalsssvsssklfssstaphetsfgeevevhnlliid
qhtfevlhahqflqneyalslvscklgkdpntyfivgtamvypeeaepkqgrivvfqysd
gklqtvaekevkgavysmvefngkllasinstvrlyewttekelrtecnhynnimalylk
tkgdfilvgdlmrsvlllaykpmegnfeeiardfnpnwmsaveildddnflgaenafnlf
vcqkdsaattdeerqhlqevglfhlgefvnvfchgslvmqnlgetstptqgsvlfgtvng
miglvtslseswynllldmqnrlnkviksvgkiehsfwrsfhterktepatgfidgdlie
sfldisrpkmqevvanlqyddgsgmkreataddlikvveeltrih

Chain 'E':
Sequence, based on SEQRES records:

>6h0gE (E:)
mdwshpqfeksavdenlyfqgggrakkpniinfdtslptshtylgadmeefhgrtlhddd
scqvipvlpqvmmilipgqtlplqlfhpqevsmvrnliqkdrtfavlaysnvqereaqfg
ttaeiyayreeqdfgieivkvkaigrqrfkvlelrtqsdgiqqakvqilpecvlpstmsa
vqleslnkcqifpskpvsredqcsykwwqkyqkrkfhcanltswprwlyslydaetlmdr
ikkqlrewdenlkddslpsnpidfsyrvaaclpiddvlriqllkigsaiqrlrceldimn
kctslcckqcqeteittkneifslslcgpmaayvnphgyvhetltvykacnlnligrpst
ehswfpgyawtvaqckicashigwkftatkkdmspqkfwgltrsallptipdtedeispd
kvilcl

Sequence, based on observed residues (ATOM records):

>6h0gE (E:)
kkpniinfdtslptshtylgadmeefhgrtlhdddscqvipvlpqvmmilipgqtlplql
fhpqevsmvrnliqkdrtfavlaysnvqereaqfgttaeiyayreeqdfgieivkvkaig
rqrfkvlelrtqsdgiqqakvqilpecvlpstmsavqleslnkcqifpskpvsredqcsy
kwwqkyqkrkfhcanltswprwlyslydaetlmdrikkqlrewdenlkddslpsnpidfs
yrvaaclpiddvlriqllkigsaiqrlrceldimnkctslcckqcqeteittkneifsls
lcgpmaayvnphgyvhetltvykacnlnligrpstehswfpgyawtvaqckicashigwk
ftatkkdmspqkfwgltrsallptipdtedeispdkvilcl

Chain 'F':
Sequence, based on SEQRES records:
```
>6h0gF (F:)
gggrplqceicgftcrqkaslnwhqrkhaet
```
Sequence, based on observed residues (ATOM records):
```
>6h0gF (F:)
ggrplqceicgftcrqkaslnwhqrkhaet
```