SCOPe 2.08: Structural Classification of Proteins

PDB entry 6h0f

View 6h0f on RCSB PDB site
Description: structure of ddb1-crbn-pomalidomide complex bound to ikzf1(zf2)
Deposited on 2018-07-09, released 2018-11-07
The last revision was dated 2019-10-30, with a file datestamp of 2019-10-25.
Experiment type: XRAY
Resolution: 3.25 Å
R-factor: N/A
AEROSPACI score: 0.11 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1
Species: Homo sapiens [TaxId:9606]
Gene: DDB1, XAP1
Database cross-references and differences (RAF-indexed):
- PDB 6H0F
- PDB 6H0F (Start-855)
Chain 'B':
Compound: Protein cereblon
Species: Homo sapiens [TaxId:9606]
Gene: CRBN, AD-006
Database cross-references and differences (RAF-indexed):
- Uniprot Q96SW2 (Start-425)
Chain 'C':
Compound: DNA-binding protein Ikaros
Species: Homo sapiens [TaxId:9606]
Gene: IKZF1, IK1, IKAROS, LYF1, ZNFN1A1
Database cross-references and differences (RAF-indexed):
- Uniprot Q13422 (4-End)
  - expression tag (1-3)
Chain 'D':
Compound: DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1
Species: Homo sapiens [TaxId:9606]
Gene: DDB1, XAP1
Database cross-references and differences (RAF-indexed):
- PDB 6H0F
- PDB 6H0F (Start-855)
Chain 'E':
Compound: Protein cereblon
Species: Homo sapiens [TaxId:9606]
Gene: CRBN, AD-006
Database cross-references and differences (RAF-indexed):
- Uniprot Q96SW2 (Start-425)
Chain 'F':
Compound: DNA-binding protein Ikaros
Species: Homo sapiens [TaxId:9606]
Gene: IKZF1, IK1, IKAROS, LYF1, ZNFN1A1
Database cross-references and differences (RAF-indexed):
- Uniprot Q13422 (4-End)
  - expression tag (1-3)
Chain 'G':
Compound: DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1
Species: Homo sapiens [TaxId:9606]
Gene: DDB1, XAP1
Database cross-references and differences (RAF-indexed):
- PDB 6H0F
- PDB 6H0F (Start-855)
Chain 'H':
Compound: Protein cereblon
Species: Homo sapiens [TaxId:9606]
Gene: CRBN, AD-006
Database cross-references and differences (RAF-indexed):
- Uniprot Q96SW2 (Start-425)
Chain 'I':
Compound: DNA-binding protein Ikaros
Species: Homo sapiens [TaxId:9606]
Gene: IKZF1, IK1, IKAROS, LYF1, ZNFN1A1
Database cross-references and differences (RAF-indexed):
- Uniprot Q13422 (4-End)
  - expression tag (1-3)
Chain 'J':
Compound: DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1
Species: Homo sapiens [TaxId:9606]
Gene: DDB1, XAP1
Database cross-references and differences (RAF-indexed):
- PDB 6H0F (Start-414)
- PDB 6H0F (421-855)
Chain 'K':
Compound: Protein cereblon
Species: Homo sapiens [TaxId:9606]
Gene: CRBN, AD-006
Database cross-references and differences (RAF-indexed):
- Uniprot Q96SW2 (Start-425)
Chain 'L':
Compound: DNA-binding protein Ikaros
Species: Homo sapiens [TaxId:9606]
Gene: IKZF1, IK1, IKAROS, LYF1, ZNFN1A1
Database cross-references and differences (RAF-indexed):
- Uniprot Q13422 (4-End)
  - expression tag (1-3)
Heterogens: ZN, Y70, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

Chain 'A':
Sequence, based on SEQRES records:

>6h0fA (A:)
mhhhhhhvdeenlyfqgggrmsynyvvtaqkptavngcvtghftsaedlnlliakntrle
iyvvtaeglrpvkevgmygkiavmelfrpkgeskdllfiltakynacileykqsgesidi
itrahgnvqdrigrpsetgiigiidpecrmiglrlydglfkvipldrdnkelkafnirle
elhvidvkflygcqapticfvyqdpqgrhvktyevslrekefnkgpwkqenveaeasmvi
avpepfggaiiigqesityhngdkylaiappiikqstivchnrvdpngsryllgdmegrl
fmlllekeeqmdgtvtlkdlrvellgetsiaecltyldngvvfvgsrlgdsqlvklnvds
neqgsyvvametftnlgpivdmcvvdlerqgqgqlvtcsgafkegslriirngiggngns
geiqklhirtvplyesprkicyqevsqcfgvlssrievqdtsggttalrpsastqalsss
vsssklfssstaphetsfgeevevhnlliidqhtfevlhahqflqneyalslvscklgkd
pntyfivgtamvypeeaepkqgrivvfqysdgklqtvaekevkgavysmvefngkllasi
nstvrlyewttekelrtecnhynnimalylktkgdfilvgdlmrsvlllaykpmegnfee
iardfnpnwmsaveildddnflgaenafnlfvcqkdsaattdeerqhlqevglfhlgefv
nvfchgslvmqnlgetstptqgsvlfgtvngmiglvtslseswynllldmqnrlnkviks
vgkiehsfwrsfhterktepatgfidgdliesfldisrpkmqevvanlqyddgsgmkrea
taddlikvveeltrih