PDB entry 6h0e

View 6h0e on RCSB PDB site
Description: fab dmcbtau-22.1 in complex with tau peptide v1088-23
Deposited on 2018-07-09, released 2018-07-25
The last revision was dated 2020-03-11, with a file datestamp of 2020-03-06.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HUMAN FAB ANTIBODY FRAGMENT OF dmCBTAU-22.1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6H0E (0-221)
  • Chain 'B':
    Compound: HUMAN FAB ANTIBODY FRAGMENT OF dmCBTAU-22.1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6H0E (0-217)
  • Chain 'C':
    Compound: HUMAN FAB ANTIBODY FRAGMENT OF dmCBTAU-22.1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6H0E (0-221)
  • Chain 'D':
    Compound: HUMAN FAB ANTIBODY FRAGMENT OF dmCBTAU-22.1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6H0E (0-End)
  • Chain 'E':
    Compound: HUMAN FAB ANTIBODY FRAGMENT OF dmCBTAU-22.1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6H0E (0-End)
  • Chain 'F':
    Compound: HUMAN FAB ANTIBODY FRAGMENT OF dmCBTAU-22.1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6H0E (0-217)
  • Chain 'G':
    Compound: microtubule-associated protein tau
    Species: Mus musculus, synthetic [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: HUMAN FAB ANTIBODY FRAGMENT OF dmCBTAU-22.1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6H0E (0-221)
  • Chain 'I':
    Compound: microtubule-associated protein tau
    Species: Mus musculus, synthetic [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: microtubule-associated protein tau
    Species: Mus musculus, synthetic [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
  • Chain 'K':
    Compound: microtubule-associated protein tau
    Species: Mus musculus, synthetic [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
  • Chain 'L':
    Compound: HUMAN FAB ANTIBODY FRAGMENT OF dmCBTAU-22.1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6H0E (0-217)
  • Heterogens: GOL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6h0eA (A:)
evqlvqsgaevkkpgapvkvscetsgyrfsdyfvhwvrqapgqgpewigrirpnsggtky
aqkfqgrvtmtrdmsmntaymelsglrsddtavyycvrghcdgttcsraywgqgtlvtvs
sastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqs
sglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepk

    Sequence, based on observed residues (ATOM records):
    >6h0eA (A:)
evqlvqsgaevkkpgapvkvscetsgyrfsdyfvhwvrqapgqgpewigrirpnsggtky
aqkfqgrvtmtrdmsmntaymelsglrsddtavyycvrghcdgttcsraywgqgtlvtvs
sastkgpsvfplapsgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysl
ssvvtvpssslgtqtyicnvnhkpsntkvdkrvepk

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records:
    >6h0eB (B:)
dvvmtqsplslpvtpgepasiscrssqsllhrsghkylhwylqrpgqspqvliylgsnra
sgvpdrfsgsgsgtdftlkisrveaedvglyycmqtlqtpwtfgqgtkveikrtvaapsv
fifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl
sstltlskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6h0eC (C:)
evqlvqsgaevkkpgapvkvscetsgyrfsdyfvhwvrqapgqgpewigrirpnsggtky
aqkfqgrvtmtrdmsmntaymelsglrsddtavyycvrghcdgttcsraywgqgtlvtvs
sastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqs
sglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepk

    Sequence, based on observed residues (ATOM records):
    >6h0eC (C:)
evqlvqsgaevkkpgapvkvscetsgyrfsdyfvhwvrqapgqgpewigrirpnsggtky
aqkfqgrvtmtrdmsmntaymelsglrsddtavyycvrghcdgttcsraywgqgtlvtvs
sastkgpsvfplapsskggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgl
yslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepk

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6h0eD (D:)
dvvmtqsplslpvtpgepasiscrssqsllhrsghkylhwylqrpgqspqvliylgsnra
sgvpdrfsgsgsgtdftlkisrveaedvglyycmqtlqtpwtfgqgtkveikrtvaapsv
fifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl
sstltlskadyekhkvyacevthqglsspvtksfnrge

    Sequence, based on observed residues (ATOM records):
    >6h0eD (D:)
dvvmtqsplslpvtpgepasiscrssqsllhrsghkylhwylqrpgqspqvliylgsnra
sgvpdrfsgsgsgtdftlkisrveaedvglyycmqtlqtpwtfgqgtkveikrtvaapsv
fifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl
sstltlskadyekhkvyacevthqglsspvtksfnrg

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6h0eE (E:)
evqlvqsgaevkkpgapvkvscetsgyrfsdyfvhwvrqapgqgpewigrirpnsggtky
aqkfqgrvtmtrdmsmntaymelsglrsddtavyycvrghcdgttcsraywgqgtlvtvs
sastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqs
sglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepk

    Sequence, based on observed residues (ATOM records):
    >6h0eE (E:)
evqlvqsgaevkkpgapvkvscetsgyrfsdyfvhwvrqapgqgpewigrirpnsggtky
aqkfqgrvtmtrdmsmntaymelsglrsddtavyycvrghcdgttcsraywgqgtlvtvs
sastkgpsvfplapsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglys
lssvvtvpssslgtqtyicnvnhkpsntkvdkrvep

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records:
    >6h0eF (F:)
dvvmtqsplslpvtpgepasiscrssqsllhrsghkylhwylqrpgqspqvliylgsnra
sgvpdrfsgsgsgtdftlkisrveaedvglyycmqtlqtpwtfgqgtkveikrtvaapsv
fifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl
sstltlskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6h0eG (G:)
rhlsnvsstgsidmvdspqlatla

    Sequence, based on observed residues (ATOM records):
    >6h0eG (G:)
dmvdspqlat

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6h0eH (H:)
evqlvqsgaevkkpgapvkvscetsgyrfsdyfvhwvrqapgqgpewigrirpnsggtky
aqkfqgrvtmtrdmsmntaymelsglrsddtavyycvrghcdgttcsraywgqgtlvtvs
sastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqs
sglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepk

    Sequence, based on observed residues (ATOM records):
    >6h0eH (H:)
evqlvqsgaevkkpgapvkvscetsgyrfsdyfvhwvrqapgqgpewigrirpnsggtky
aqkfqgrvtmtrdmsmntaymelsglrsddtavyycvrghcdgttcsraywgqgtlvtvs
sastkgpsvfplapssgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglys
lssvvtvpssslgtqtyicnvnhkpsntkvdkrvepk

  • Chain 'I':
    Sequence, based on SEQRES records:
    >6h0eI (I:)
rhlsnvsstgsidmvdspqlatla

    Sequence, based on observed residues (ATOM records):
    >6h0eI (I:)
mvdspqlat

  • Chain 'J':
    Sequence, based on SEQRES records:
    >6h0eJ (J:)
rhlsnvsstgsidmvdspqlatla

    Sequence, based on observed residues (ATOM records):
    >6h0eJ (J:)
mvdspqla

  • Chain 'K':
    Sequence, based on SEQRES records:
    >6h0eK (K:)
rhlsnvsstgsidmvdspqlatla

    Sequence, based on observed residues (ATOM records):
    >6h0eK (K:)
mvdspqla

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records:
    >6h0eL (L:)
dvvmtqsplslpvtpgepasiscrssqsllhrsghkylhwylqrpgqspqvliylgsnra
sgvpdrfsgsgsgtdftlkisrveaedvglyycmqtlqtpwtfgqgtkveikrtvaapsv
fifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl
sstltlskadyekhkvyacevthqglsspvtksfnrge