PDB entry 6gzh

View 6gzh on RCSB PDB site
Description: Crystal Structure of Human CDK9/cyclinT1 with A86
Class: transferase
Keywords: CDK9, kinase inhibitor, A86, transferase
Deposited on 2018-07-04, released 2018-08-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-10-03, with a file datestamp of 2018-09-28.
Experiment type: XRAY
Resolution: 3.17 Å
R-factor: N/A
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cyclin-dependent kinase 9
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK9, CDC2L4, TAK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6gzha_
  • Chain 'B':
    Compound: Cyclin-T1
    Species: Homo sapiens [TaxId:9606]
    Gene: CCNT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60563
      • engineered mutation (76)
      • engineered mutation (95)
      • engineered mutation (240)
    Domains in SCOPe 2.08: d6gzhb1, d6gzhb2
  • Heterogens: LCI, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6gzhA (A:)
makqydsvecpfcdevskyeklakigqgtfgevfkarhrktgqkvalkkvlmenekegfp
italreikilqllkhenvvnlieicrtkaspynrckgsiylvfdfcehdlagllsnvlvk
ftlseikrvmqmllnglyyihrnkilhrdmkaanvlitrdgvlkladfglarafslakns
qpnrytnrvvtlwyrppelllgerdygppidlwgagcimaemwtrspimqgnteqhqlal
isqlcgsitpevwpnvdnyelyeklelvkgqkrkvkdrlkayvrdpyaldlidkllvldp
aqridsddalnhdffwsdpmpsdlkg

    Sequence, based on observed residues (ATOM records): (download) 
    >6gzhA (A:)
vecpfcdevskyeklakigqgtfgevfkarhrktgqkvalkkvlmenekegfpitalrei
kilqllkhenvvnlieicrtkasgsiylvfdfcehdlagllsnvlvkftlseikrvmqml
lnglyyihrnkilhrdmkaanvlitrdgvlkladfglarafslaqpnrytnrvvtlwyrp
pelllgerdygppidlwgagcimaemwtrspimqgnteqhqlalisqlcgsitpevwpnv
dnyelyeklelvkgqkrkvkdrlkayvrdpyaldlidkllvldpaqridsddalnhdffw
sdpmpsdlkg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6gzhB (B:)
megerknnnkrwyftreqlenspsrrfgvdpdkelsyrqqaanllqdmgqrlnvsqltin
taivymhrfymiqsftrfpgnsvapaalflaakvegqpkklehvikvahtclhpqeslpd
trseaylqqvqdlvilesiilqtlgfeltidhphthvvkctqlvraskdlaqtsyfmatn
slhlttfslqytppvvacvcihlackwsnweipvstdgkhwweyvdatvtlelldelthe
llqilektpnrlkriwnwraceaakktkaddrgtdektseqtilnmisqsssdttiaglm
smststtsavpslpvseesssnltsvemlpgkrwlssqpsfkleptqghrtsenlaltgv
dhslpqdgsnafisqkqnsksvpsakvslkeyrakhaeelaaqkrqlenmeanvksqyay
aaqnllshhdshssvilkmpiegsenperpflekadktalkmripvaggdkaasskpeei
kmrikvhaaadkhnsvedsvtksrehkekhkthpsnhhhhhnhhshkhshsqlpvgtgnk
rpgdpkhssqtsnlahktyslsssfssssstrkrgpseetggavfdhpakiakstksssl
nfsfpslptmgqmpghssdtsglsfsqpscktrvphskldkgptganghnttqtidyqdt
vnmlhsllsaqgvqptqptafefvrpysdylnprsggissrsgntdkprppplpsepppp
lpplpk

    Sequence, based on observed residues (ATOM records): (download) 
    >6gzhB (B:)
nnkrwyftreqlenspsrrfgvdpdkelsyrqqaanllqdmgqrlnvsqltintaivymh
rfymiqsftrfpgnsvapaalflaakvegqpkklehvikvahtclhpqeslpdtrseayl
qqvqdlvilesiilqtlgfeltidhphthvvkctqlvraskdlaqtsyfmatnslhlttf
slqytppvvacvcihlackwsnweipvstdgkhwweyvdatvtlelldelthellqilek
tpnrlkriwnwr