PDB entry 6gyo

View 6gyo on RCSB PDB site
Description: structure of human hcn4 hyperpolarization-activated cyclic nucleotide- gated ion channel in complex with camp
Deposited on 2018-06-30, released 2019-05-01
The last revision was dated 2019-12-18, with a file datestamp of 2019-12-13.
Experiment type: EM
Resolution: 3.4 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
    Species: Homo sapiens [TaxId:9606]
    Gene: HCN4
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
    Species: Homo sapiens [TaxId:9606]
    Gene: HCN4
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
    Species: Homo sapiens [TaxId:9606]
    Gene: HCN4
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
    Species: Homo sapiens [TaxId:9606]
    Gene: HCN4
    Database cross-references and differences (RAF-indexed):
  • Heterogens: CMP, PC1, PIE, 3PE, UNX

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6gyoA (A:)
smlpeaevrlgqagfmqrqfgamlqpgvnkfslrmfgsqkavereqervksagfwiihpy
sdfrfywdltmlllmvgnliiipvgitffkdenttpwivfnvvsdtfflidlvlnfrtgi
vvednteiildpqrikmkylkswfmvdfissipvdyiflivetridsevyktaralrivr
ftkilsllrllrlsrliryihqweeifhmtydlasavvrivnligmmlllchwdgclqfl
vpmlqdfpddcwvsinnmvnnswgkqysyalfkamshmlcigygrqapvgmsdvwltmls
mivgatcyamfighataliqsldssrrqyqekykqveqymsfhklppdtrqrihdyyehr
yqgkmfdeesilgelseplreeiinfncrklvasmplfanadpnfvtsmltklrfevfqp
gdyiiregtigkkmyfiqhgvvsvltkgnketkladgsyfgeiclltrgrrtasvradty
crlyslsvdnfnevleeypmmrrafetvaldrldrigkkns

    Sequence, based on observed residues (ATOM records):
    >6gyoA (A:)
mqrqfgamlqpgvnkfslrmfgsqkavereqervksagfwiihpysdfrfywdltmlllm
vgnliiipvgitffkdenttpwivfnvvsdtfflidlvlnfrtgivvednteiildpqri
kmkylkswfmvdfissipvdyiflivetridsevyktaralrivrftkilsllrllrlsr
liryihqweeifhmtydlasavvrivnligmmlllchwdgclqflvpmlqdfpddcwvsi
nnmvnnswgkqysyalfkamshmlcigygrqapvgmsdvwltmlsmivgatcyamfigha
taliqsldssrrqyqekykqveqymsfhklppdtrqrihdyyehryqgkmfdeesilgel
seplreeiinfncrklvasmplfanadpnfvtsmltklrfevfqpgdyiiregtigkkmy
fiqhgvvsvltkgnketkladgsyfgeiclltrgrrtasvradtycrlyslsvdnfnevl
eeypmmrrafetvaldrldri

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6gyoB (B:)
smlpeaevrlgqagfmqrqfgamlqpgvnkfslrmfgsqkavereqervksagfwiihpy
sdfrfywdltmlllmvgnliiipvgitffkdenttpwivfnvvsdtfflidlvlnfrtgi
vvednteiildpqrikmkylkswfmvdfissipvdyiflivetridsevyktaralrivr
ftkilsllrllrlsrliryihqweeifhmtydlasavvrivnligmmlllchwdgclqfl
vpmlqdfpddcwvsinnmvnnswgkqysyalfkamshmlcigygrqapvgmsdvwltmls
mivgatcyamfighataliqsldssrrqyqekykqveqymsfhklppdtrqrihdyyehr
yqgkmfdeesilgelseplreeiinfncrklvasmplfanadpnfvtsmltklrfevfqp
gdyiiregtigkkmyfiqhgvvsvltkgnketkladgsyfgeiclltrgrrtasvradty
crlyslsvdnfnevleeypmmrrafetvaldrldrigkkns

    Sequence, based on observed residues (ATOM records):
    >6gyoB (B:)
mqrqfgamlqpgvnkfslrmfgsqkavereqervksagfwiihpysdfrfywdltmlllm
vgnliiipvgitffkdenttpwivfnvvsdtfflidlvlnfrtgivvednteiildpqri
kmkylkswfmvdfissipvdyiflivetridsevyktaralrivrftkilsllrllrlsr
liryihqweeifhmtydlasavvrivnligmmlllchwdgclqflvpmlqdfpddcwvsi
nnmvnnswgkqysyalfkamshmlcigygrqapvgmsdvwltmlsmivgatcyamfigha
taliqsldssrrqyqekykqveqymsfhklppdtrqrihdyyehryqgkmfdeesilgel
seplreeiinfncrklvasmplfanadpnfvtsmltklrfevfqpgdyiiregtigkkmy
fiqhgvvsvltkgnketkladgsyfgeiclltrgrrtasvradtycrlyslsvdnfnevl
eeypmmrrafetvaldrldri

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6gyoC (C:)
smlpeaevrlgqagfmqrqfgamlqpgvnkfslrmfgsqkavereqervksagfwiihpy
sdfrfywdltmlllmvgnliiipvgitffkdenttpwivfnvvsdtfflidlvlnfrtgi
vvednteiildpqrikmkylkswfmvdfissipvdyiflivetridsevyktaralrivr
ftkilsllrllrlsrliryihqweeifhmtydlasavvrivnligmmlllchwdgclqfl
vpmlqdfpddcwvsinnmvnnswgkqysyalfkamshmlcigygrqapvgmsdvwltmls
mivgatcyamfighataliqsldssrrqyqekykqveqymsfhklppdtrqrihdyyehr
yqgkmfdeesilgelseplreeiinfncrklvasmplfanadpnfvtsmltklrfevfqp
gdyiiregtigkkmyfiqhgvvsvltkgnketkladgsyfgeiclltrgrrtasvradty
crlyslsvdnfnevleeypmmrrafetvaldrldrigkkns

    Sequence, based on observed residues (ATOM records):
    >6gyoC (C:)
mqrqfgamlqpgvnkfslrmfgsqkavereqervksagfwiihpysdfrfywdltmlllm
vgnliiipvgitffkdenttpwivfnvvsdtfflidlvlnfrtgivvednteiildpqri
kmkylkswfmvdfissipvdyiflivetridsevyktaralrivrftkilsllrllrlsr
liryihqweeifhmtydlasavvrivnligmmlllchwdgclqflvpmlqdfpddcwvsi
nnmvnnswgkqysyalfkamshmlcigygrqapvgmsdvwltmlsmivgatcyamfigha
taliqsldssrrqyqekykqveqymsfhklppdtrqrihdyyehryqgkmfdeesilgel
seplreeiinfncrklvasmplfanadpnfvtsmltklrfevfqpgdyiiregtigkkmy
fiqhgvvsvltkgnketkladgsyfgeiclltrgrrtasvradtycrlyslsvdnfnevl
eeypmmrrafetvaldrldri

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6gyoD (D:)
smlpeaevrlgqagfmqrqfgamlqpgvnkfslrmfgsqkavereqervksagfwiihpy
sdfrfywdltmlllmvgnliiipvgitffkdenttpwivfnvvsdtfflidlvlnfrtgi
vvednteiildpqrikmkylkswfmvdfissipvdyiflivetridsevyktaralrivr
ftkilsllrllrlsrliryihqweeifhmtydlasavvrivnligmmlllchwdgclqfl
vpmlqdfpddcwvsinnmvnnswgkqysyalfkamshmlcigygrqapvgmsdvwltmls
mivgatcyamfighataliqsldssrrqyqekykqveqymsfhklppdtrqrihdyyehr
yqgkmfdeesilgelseplreeiinfncrklvasmplfanadpnfvtsmltklrfevfqp
gdyiiregtigkkmyfiqhgvvsvltkgnketkladgsyfgeiclltrgrrtasvradty
crlyslsvdnfnevleeypmmrrafetvaldrldrigkkns

    Sequence, based on observed residues (ATOM records):
    >6gyoD (D:)
mqrqfgamlqpgvnkfslrmfgsqkavereqervksagfwiihpysdfrfywdltmlllm
vgnliiipvgitffkdenttpwivfnvvsdtfflidlvlnfrtgivvednteiildpqri
kmkylkswfmvdfissipvdyiflivetridsevyktaralrivrftkilsllrllrlsr
liryihqweeifhmtydlasavvrivnligmmlllchwdgclqflvpmlqdfpddcwvsi
nnmvnnswgkqysyalfkamshmlcigygrqapvgmsdvwltmlsmivgatcyamfigha
taliqsldssrrqyqekykqveqymsfhklppdtrqrihdyyehryqgkmfdeesilgel
seplreeiinfncrklvasmplfanadpnfvtsmltklrfevfqpgdyiiregtigkkmy
fiqhgvvsvltkgnketkladgsyfgeiclltrgrrtasvradtycrlyslsvdnfnevl
eeypmmrrafetvaldrldri