PDB entry 6gxu

View 6gxu on RCSB PDB site
Description: crystal structure of schistosoma mansoni hdac8 complexed with an hydroxamate 3
Deposited on 2018-06-27, released 2018-08-15
The last revision was dated 2018-08-29, with a file datestamp of 2018-08-24.
Experiment type: XRAY
Resolution: 1.92 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone deacetylase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: HDAC8
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Histone deacetylase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: HDAC8
    Database cross-references and differences (RAF-indexed):
    • Uniprot A5H660 (Start-440)
      • expression tag (441-446)
  • Chain 'C':
    Compound: Histone deacetylase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: HDAC8
    Database cross-references and differences (RAF-indexed):
    • Uniprot A5H660 (Start-440)
      • expression tag (441-446)
  • Chain 'D':
    Compound: Histone deacetylase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: HDAC8
    Database cross-references and differences (RAF-indexed):
  • Heterogens: FG8, ZN, K, DMF, GOL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6gxuA (A:)
hmsvgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeav
tafhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgsl
aaasalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstppetspnrqtr
vlyvdldlhhgdgveeafwysprvvtfsvhhaspgffpgtgtwnmvdndklpiflngagr
grfsafnlpleegindldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltn
fypnlnldsdcdsecslsgylyaikkilswkvptlilggggynfpdtarlwtrvtaltie
evkgkkmtispeipehsyfsrygpdfeldidyfpheshnktldsiqkhhrrileqlrnya
dlnkliydydqvyqlynltgmgslvpr

    Sequence, based on observed residues (ATOM records):
    >6gxuA (A:)
svgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeavta
fhsteyvdalkklqmlhceekltaddellmdsfslnydcpgfpsvfdyslaavqgslaaa
salicrhcevvinwgggwhhakrseasgfcylndivlaihrlvssqtrvlyvdldlhhgd
gveeafwysprvvtfsvhhaspgffpgtgtwnlpiflngagrgrfsafnlpleegindld
wsnaigpildslniviqpsyvvvqcgadclatdphrifrltnfypslsgylyaikkilsw
kvptlilggggynfpdtarlwtrvtaltieevkgkkmtispeipehsyfsrygpdfeldi
dyfpdsiqkhhrrileqlrnyadlnkliydy

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6gxuB (B:)
hmsvgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeav
tafhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgsl
aaasalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstppetspnrqtr
vlyvdldlhhgdgveeafwysprvvtfsvhhaspgffpgtgtwnmvdndklpiflngagr
grfsafnlpleegindldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltn
fypnlnldsdcdsecslsgylyaikkilswkvptlilggggynfpdtarlwtrvtaltie
evkgkkmtispeipehsyfsrygpdfeldidyfpheshnktldsiqkhhrrileqlrnya
dlnkliydydqvyqlynltgmgslvpr

    Sequence, based on observed residues (ATOM records):
    >6gxuB (B:)
svgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeavta
fhsteyvdalkklqmlhceltaddellmdsfslnydcpgfpsvfdyslaavqgslaaasa
licrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstqtrvlyvdldlhhgdg
veeafwysprvvtfsvhhaspgffpgtgtwnlpiflngagrgrfsafnlpleegindldw
snaigpildslniviqpsyvvvqcgadclatdphrifrltnfypslsgylyaikkilswk
vptlilggggynfpdtarlwtrvtaltieevkgkkmtispeipehsyfsrygpdfeldid
yfphedsiqkhhrrileqlrnyadlnkliydydqvyqlynltgmgslvpr

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6gxuC (C:)
hmsvgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeav
tafhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgsl
aaasalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstppetspnrqtr
vlyvdldlhhgdgveeafwysprvvtfsvhhaspgffpgtgtwnmvdndklpiflngagr
grfsafnlpleegindldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltn
fypnlnldsdcdsecslsgylyaikkilswkvptlilggggynfpdtarlwtrvtaltie
evkgkkmtispeipehsyfsrygpdfeldidyfpheshnktldsiqkhhrrileqlrnya
dlnkliydydqvyqlynltgmgslvpr

    Sequence, based on observed residues (ATOM records):
    >6gxuC (C:)
svgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeavta
fhsteyvdalkklqmlhceeltaddellmdsfslnydcpgfpsvfdyslaavqgslaaas
alicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstqtrvlyvdldlhhgd
gveeafwysprvvtfsvhhaspgffpgtgtwnlpiflngagrgrfsafnlpleegindld
wsnaigpildslniviqpsyvvvqcgadclatdphrifrltnfypslsgylyaikkilsw
kvptlilggggynfpdtarlwtrvtaltieevkgkkmtispeipehsyfsrygpdfeldi
dyfphedsiqkhhrrileqlrnyadlnkliydydqvyqlynltgmgslvpr

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6gxuD (D:)
hmsvgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeav
tafhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgsl
aaasalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstppetspnrqtr
vlyvdldlhhgdgveeafwysprvvtfsvhhaspgffpgtgtwnmvdndklpiflngagr
grfsafnlpleegindldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltn
fypnlnldsdcdsecslsgylyaikkilswkvptlilggggynfpdtarlwtrvtaltie
evkgkkmtispeipehsyfsrygpdfeldidyfpheshnktldsiqkhhrrileqlrnya
dlnkliydydqvyqlynltgmgslvpr

    Sequence, based on observed residues (ATOM records):
    >6gxuD (D:)
svgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeavta
fhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgslaa
asalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstrvlyvdldlhhgd
gveeafwysprvvtfsvhhaspgffpgtgtwnmpiflngagrgrfsafnlpleegindld
wsnaigpildslniviqpsyvvvqcgadclatdphrifrltnfyplsgylyaikkilswk
vptlilggggynfpdtarlwtrvtaltieevkgkkmtispeipehsyfsrygpdfeldid
yfpdsiqkhhrrileqlrnyadlnkliydydqvyqly